Viral Imprinting and Vaccine Design of Influenza and Other Viruses
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Influenza Virus Vaccines".
Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 35215
Special Issue Editor
Special Issue Information
Dear Colleagues,
A host’s first encounter with a virus or viral vaccine results in viral or vaccine imprinting. The imprinting event initiates a cascade of immune events that culminates in immunological memory impacting subsequent host responses to viruses with similar homology. Viral imprinting is a major determinant of viral disease outcome and vaccine efficacy for both circulating and emerging viruses. Well known examples of viral imprinting include influenza virus, respiratory syncytial virus, and dengue viral imprinting. The importance of imprinting must be considered in vaccine design because as seen with RSV, Dengue, and influenza vaccines, first exposure imprinting has a direct impact on vaccine efficacy and vaccine complications. Other viruses that should also be considered in the conversation of viral imprinting include viruses with related yet antigenically divergent family members including Ebola viruses (filoviruses family) and other arboviruses including Zika virus, chikungunya virus, and yellow fever virus. This Special Issue of Vaccines highlights the new and emerging field of viral imprinting and its importance in vaccine design and development. This issue includes articles investigating the epidemiological outcomes of viral imprinting and preimmunity in the context of current disease outbreaks as well as mechanistic studies focusing on imprinting and memory recall during secondary exposure. With this collection we aim to provide a foundation for conceptualizing the universality of the viral imprinting responses in the host and how this can be leveraged for vaccine design.
Dr. Alyson Kelvin
Guest Editor
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Keywords
- Imprinting
- Viral Imprinting
- Influenza viruses
- Dengue virus
- Yellow Fever Virus
- West Nile Virus
- Flavivirus
- Chikungunya Virus
- Filovirus
- Respiratory Syncytial Virus
- Vaccine design
- Vaccine responses
- Preimmunity
- Immune history
- Broadly neutralizing antibodies
- Universal vaccine
- Memory B cells
- Antibody dependent cell cytotoxicity
- Antibody enhanced disease Sequential infection
- Sequential vaccination
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