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Vaccines, Volume 6, Issue 3

September 2018 - 31 articles

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Articles (31)

  • Review
  • Open Access
13 Citations
5,618 Views
10 Pages

BDCA1+CD14+ Immunosuppressive Cells in Cancer, a Potential Target?

  • Thomas J. Van Ee,
  • Heleen H. Van Acker,
  • Tom G. Van Oorschot,
  • Viggo F. Van Tendeloo,
  • Evelien L. Smits,
  • Ghaith Bakdash,
  • Gerty Schreibelt and
  • I. Jolanda M. De Vries

19 September 2018

Dendritic cell (DC) vaccines show promising effects in cancer immunotherapy. However, their efficacy is affected by a number of factors, including (1) the quality of the DC vaccine and (2) tumor immune evasion. The recently characterized BDCA1+CD14+...

  • Review
  • Open Access
205 Citations
14,532 Views
23 Pages

Cathelicidins: Immunomodulatory Antimicrobials

  • Roel M. Van Harten,
  • Esther Van Woudenbergh,
  • Albert Van Dijk and
  • Henk P. Haagsman

14 September 2018

Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions. These effector molecules of the innate immune system of many vertebrates are diverse in their amino acid sequence but share physicochemical characteristics lik...

  • Article
  • Open Access
19 Citations
8,174 Views
20 Pages

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

  • Sun-Young Sunwoo,
  • Michael Schotsaert,
  • Igor Morozov,
  • Anne Sally Davis,
  • Yuhao Li,
  • Jinhwa Lee,
  • Chester McDowell,
  • Philip Meade,
  • Raffael Nachbagauer and
  • Adolfo García-Sastre
  • + 3 authors

14 September 2018

The antigenically conserved hemagglutinin stalk region is a target for universal influenza virus vaccines since antibodies against it can provide broad protection against influenza viruses of different subtypes. We tested a universal influenza virus...

  • Review
  • Open Access
19 Citations
9,782 Views
13 Pages

Zika Virus Vaccines: Challenges and Perspectives

  • Raquel Das Neves Almeida,
  • Trina Racine,
  • Kelly G. Magalhães and
  • Gary P. Kobinger

13 September 2018

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. T...

  • Review
  • Open Access
104 Citations
14,415 Views
8 Pages

8 September 2018

Cervical cancer is a critical public health issue in sub-Saharan Africa (SSA), where it is the second leading cause of cancer among women and the leading cause of female cancer deaths. Incidence and mortality rates are substantially higher than in hi...

  • Article
  • Open Access
57 Citations
9,471 Views
17 Pages

4 September 2018

Neisseria gonorrhoeae is a strict human pathogen responsible for more than 100 million new sexually transmitted infections worldwide each year. Due to the global emergence of antibiotic resistance, the Center for Disease control (CDC) recently listed...

  • Article
  • Open Access
35 Citations
5,187 Views
12 Pages

31 August 2018

The relative burden of community-acquired pneumonia (CAP) in older adults (≥65 years old) compared to other serious diseases is important to prioritize preventive treatment. A retrospective analysis was conducted using the 2014 National Readmissio...

  • Review
  • Open Access
27 Citations
10,842 Views
15 Pages

30 August 2018

For centuries, the development of vaccines to prevent infectious disease was an empirical process. From smallpox variolation in Song dynasty China, through the polysaccharide capsule vaccines developed in the 1970s, vaccines were made either from the...

  • Article
  • Open Access
16 Citations
4,555 Views
15 Pages

β-Defensins Coordinate In Vivo to Inhibit Bacterial Infections of the Trachea

  • Lisa Kathleen Ryan,
  • Jichuan Wu,
  • Kyell Schwartz,
  • Sunghan Yim and
  • Gill Diamond

28 August 2018

β-defensins are predicted to play an important role in innate immunity against bacterial infections in the airway. We previously observed that a type III-secretion product of Bordetella bronchiseptica inhibits the NF-κB-mediated induction...

  • Review
  • Open Access
9 Citations
5,046 Views
10 Pages

25 August 2018

Endometrial stromal sarcomas are a subtype of uterine sarcomas that are characterized by recurrent chromosomal translocations, resulting in the expression of tumor-specific fusion proteins that contribute to their tumorigenicity. These characteristic...

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