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Vaccines 2018, 6(3), 63; https://doi.org/10.3390/vaccines6030063

Cathelicidins: Immunomodulatory Antimicrobials

Division Molecular Host Defence, Dept. Infectious diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
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Author to whom correspondence should be addressed.
Authors contributed equally.
Received: 17 July 2018 / Revised: 30 August 2018 / Accepted: 12 September 2018 / Published: 14 September 2018
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Abstract

Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions. These effector molecules of the innate immune system of many vertebrates are diverse in their amino acid sequence but share physicochemical characteristics like positive charge and amphipathicity. Besides being antimicrobial, cathelicidins have a wide variety in immunomodulatory functions, both boosting and inhibiting inflammation, directing chemotaxis, and effecting cell differentiation, primarily towards type 1 immune responses. In this review, we will examine the biology and various functions of cathelicidins, focusing on putting in vitro results in the context of in vivo situations. The pro-inflammatory and anti-inflammatory functions are highlighted, as well both direct and indirect effects on chemotaxis and cell differentiation. Additionally, we will discuss the potential and limitations of using cathelicidins as immunomodulatory or antimicrobial drugs. View Full-Text
Keywords: cathelicidins; host defense peptides; antimicrobials; immunomodulation; chemotaxis; adjuvants cathelicidins; host defense peptides; antimicrobials; immunomodulation; chemotaxis; adjuvants
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Van Harten, R.M.; Van Woudenbergh, E.; Van Dijk, A.; Haagsman, H.P. Cathelicidins: Immunomodulatory Antimicrobials. Vaccines 2018, 6, 63.

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