BDCA1+CD14+ Immunosuppressive Cells in Cancer, a Potential Target?
AbstractDendritic cell (DC) vaccines show promising effects in cancer immunotherapy. However, their efficacy is affected by a number of factors, including (1) the quality of the DC vaccine and (2) tumor immune evasion. The recently characterized BDCA1+CD14+ immunosuppressive cells combine both aspects; their presence in DC vaccines may directly hamper vaccine efficacy, whereas, in patients, BDCA1+CD14+ cells may suppress the induced immune response in an antigen-specific manner systemically and at the tumor site. We hypothesize that BDCA1+CD14+ cells are present in a broad spectrum of cancers and demand further investigation to reveal treatment opportunities and/or improvement for DC vaccines. In this review, we summarize the findings on BDCA1+CD14+ cells in solid cancers. In addition, we evaluate the presence of BDCA1+CD14+ cells in leukemic cancers. Preliminary results suggest that the presence of BDCA1+CD14+ cells correlates with clinical features of acute and chronic myeloid leukemia. Future research focusing on the differentiation from monocytes towards BDCA1+CD14+ cells could reveal more about their cell biology and clinical significance. Targeting these cells in cancer patients may improve the outcome of cancer immunotherapy. View Full-Text
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Van Ee, T.J.; Van Acker, H.H.; Van Oorschot, T.G.; Van Tendeloo, V.F.; Smits, E.L.; Bakdash, G.; Schreibelt, G.; De Vries, I.J.M. BDCA1+CD14+ Immunosuppressive Cells in Cancer, a Potential Target? Vaccines 2018, 6, 65.
Van Ee TJ, Van Acker HH, Van Oorschot TG, Van Tendeloo VF, Smits EL, Bakdash G, Schreibelt G, De Vries IJM. BDCA1+CD14+ Immunosuppressive Cells in Cancer, a Potential Target? Vaccines. 2018; 6(3):65.Chicago/Turabian Style
Van Ee, Thomas J.; Van Acker, Heleen H.; Van Oorschot, Tom G.; Van Tendeloo, Viggo F.; Smits, Evelien L.; Bakdash, Ghaith; Schreibelt, Gerty; De Vries, I. J.M. 2018. "BDCA1+CD14+ Immunosuppressive Cells in Cancer, a Potential Target?" Vaccines 6, no. 3: 65.
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