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Vaccines 2018, 6(3), 56; https://doi.org/10.3390/vaccines6030056

Endometrial Stromal Sarcomas: A Revision of Their Potential as Targets for Immunotherapy

1
Division of Gynecologic Oncology, Department of Oncology, KU Leuven, 3000 Leuven, Belgium
2
Leuven Cancer Institute (LKI), 3000 Leuven, Belgium
3
Division of Gynecology & Obstetrics, UZ Leuven, 3000 Leuven, Belgium
4
Center for Gynecologic Oncology Amsterdam (CGOA), Antoni Van Leeuwenhoek-Netherlands Cancer Institute (Avl-NKI) and University Medical Centra (UMC), 1066 CX Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 13 July 2018 / Revised: 17 August 2018 / Accepted: 22 August 2018 / Published: 25 August 2018
(This article belongs to the Special Issue Therapeutic Vaccines and Cancer Immunotherapy)
Full-Text   |   PDF [809 KB, uploaded 25 August 2018]   |  

Abstract

Endometrial stromal sarcomas are a subtype of uterine sarcomas that are characterized by recurrent chromosomal translocations, resulting in the expression of tumor-specific fusion proteins that contribute to their tumorigenicity. These characteristics make the translocation breakpoints promising targets for immunotherapeutic approaches. In this review, we first describe the current knowledge about the classification of endometrial stromal sarcomas, and their molecular and genetic characteristics. Next, we summarize the available data on the use of translocation breakpoints as immunotherapeutic targets. Finally, we propose a roadmap to evaluate the feasibility of immunologic targeting of the endometrial stromal sarcoma-specific translocations in patients with recurrent disease. View Full-Text
Keywords: endometrial stromal sarcoma; recurrent chromosomal translocations; neoantigen; immunotherapy endometrial stromal sarcoma; recurrent chromosomal translocations; neoantigen; immunotherapy
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Tuyaerts, S.; Amant, F. Endometrial Stromal Sarcomas: A Revision of Their Potential as Targets for Immunotherapy. Vaccines 2018, 6, 56.

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