Next Article in Journal
Cathelicidins: Immunomodulatory Antimicrobials
Next Article in Special Issue
Assay Challenges for Emerging Infectious Diseases: The Zika Experience
Previous Article in Journal
Prevention of Cervical Cancer in Sub-Saharan Africa: The Advantages and Challenges of HPV Vaccination
Article Menu

Export Article

Open AccessReview

Zika Virus Vaccines: Challenges and Perspectives

Laboratory of Immunology and Inflammation, University of Brasilia, Brasilia 70910-900, Brazil
Centre de Recherche en Infectiologie du CHU de Québec—Université Laval, Québec, QC G1V 4G2, Canada
Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
Départment de Microbiologie-Infectiologie et D’immunologie, Université Laval, Québc, QC G1V 0A6, Canada
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4238, USA
Author to whom correspondence should be addressed.
Vaccines 2018, 6(3), 62;
Received: 20 August 2018 / Revised: 8 September 2018 / Accepted: 11 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Development of Vaccines against Zika Virus)
PDF [658 KB, uploaded 13 September 2018]


Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression. View Full-Text
Keywords: zika virus; flaviviruses; vaccines; animal models; immunopathology; immune responses; challenge; clinical trials zika virus; flaviviruses; vaccines; animal models; immunopathology; immune responses; challenge; clinical trials

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Das Neves Almeida, R.; Racine, T.; Magalhães, K.G.; Kobinger, G.P. Zika Virus Vaccines: Challenges and Perspectives. Vaccines 2018, 6, 62.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top