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Vaccines 2018, 6(3), 62; https://doi.org/10.3390/vaccines6030062

Zika Virus Vaccines: Challenges and Perspectives

1
Laboratory of Immunology and Inflammation, University of Brasilia, Brasilia 70910-900, Brazil
2
Centre de Recherche en Infectiologie du CHU de Québec—Université Laval, Québec, QC G1V 4G2, Canada
3
Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
4
Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
5
Départment de Microbiologie-Infectiologie et D’immunologie, Université Laval, Québc, QC G1V 0A6, Canada
6
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4238, USA
*
Author to whom correspondence should be addressed.
Received: 20 August 2018 / Revised: 8 September 2018 / Accepted: 11 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Development of Vaccines against Zika Virus)
Full-Text   |   PDF [658 KB, uploaded 13 September 2018]   |  

Abstract

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression. View Full-Text
Keywords: zika virus; flaviviruses; vaccines; animal models; immunopathology; immune responses; challenge; clinical trials zika virus; flaviviruses; vaccines; animal models; immunopathology; immune responses; challenge; clinical trials
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Das Neves Almeida, R.; Racine, T.; Magalhães, K.G.; Kobinger, G.P. Zika Virus Vaccines: Challenges and Perspectives. Vaccines 2018, 6, 62.

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