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Antioxidants, Volume 12, Issue 9

September 2023 - 137 articles

Cover Story: The oxidative burst produced by NADPH oxidase enzymes (NOXs) within macrophages and neutrophils incites a potent bactericidal effect in response to invading pathogens. Aberrant activation of these enzymes has been implicated in a variety of diseases, including neurodegeneration. In this work, we developed a novel, brain-permeable NOX inhibitor, TG15-132, as a potential neuroprotective agent. TG15-132 demonstrated potent inhibition of Nox2 activity in neutrophil-like cells. Extended treatment with TG15-132 in human macrophages downregulated the expression of genes encoding Nox2 subunits and several pro-inflammatory cytokines. In rodent models, TG15-132 exhibited a long plasma half-life and a high brain-to-blood level ratio. Therefore, TG15-132 may serve as a promising neuroprotective agent. View this paper
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Articles (137)

  • Article
  • Open Access
18 Citations
4,469 Views
20 Pages

Assessment of Bio-Compounds Content, Antioxidant Activity, and Neuroprotective Effect of Red Cabbage (Brassica oleracea var. Capitata rubra) Processed by Convective Drying at Different Temperatures

  • Antonio Vega-Galvez,
  • Luis S. Gomez-Perez,
  • Francisca Zepeda,
  • René L. Vidal,
  • Felipe Grunenwald,
  • Nicol Mejías,
  • Alexis Pasten,
  • Michael Araya and
  • Kong Shun Ah-Hen

21 September 2023

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and no efficient therapy able to cure or slow down PD is available. In this study, dehydrated red cabbage was evaluated as a novel source of bio-compounds with neuro...

  • Article
  • Open Access
7 Citations
2,432 Views
20 Pages

Colorants and Antioxidants Deriving from Methylglyoxal and Heterocyclic Maillard Reaction Intermediates

  • Leon Valentin Bork,
  • Maximilian Baumann,
  • Tobias Stobernack,
  • Sascha Rohn and
  • Clemens Kanzler

21 September 2023

The Maillard reaction is well known for producing antioxidant compounds alongside colored substances. Low-molecular-weight antioxidant intermediates such as maltol (MAL) or norfuraneol (NF) are well described, but it is still unclear which of these M...

  • Review
  • Open Access
30 Citations
4,982 Views
14 Pages

Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients

  • Prima Buranasin,
  • Hiromi Kominato,
  • Koji Mizutani,
  • Risako Mikami,
  • Natsumi Saito,
  • Kohei Takeda and
  • Takanori Iwata

21 September 2023

Diabetes mellitus (DM) is associated with periodontal disease. Clinically, periodontal treatment is less effective for patients with DM. Oxidative stress is one of the mechanisms that link DM to periodontitis. The production of reactive oxygen specie...

  • Review
  • Open Access
13 Citations
3,569 Views
17 Pages

21 September 2023

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The brain is one of the organs involved in sepsis, and sepsis-induced brain injury manifests as sepsis-associated encephalopathy (SAE). SAE m...

  • Review
  • Open Access
19 Citations
7,003 Views
15 Pages

Antimicrobial, Antioxidant, and Anti-Inflammatory Properties of Monofloral Honeys from Chile

  • Erick Poulsen-Silva,
  • Felipe Gordillo-Fuenzalida,
  • Patricia Velásquez,
  • Felipe M. Llancalahuen,
  • Rodrigo Carvajal,
  • Mauricio Cabaña-Brunod and
  • María Carolina Otero

21 September 2023

Honey is a mixture of compounds produced by bees that has been appreciated by humanity since the creation of the oldest civilizations. It has multiple uses and can be a highly nutritional and healing substance. It has been used in traditional medicin...

  • Review
  • Open Access
6 Citations
3,378 Views
12 Pages

Protecting the Eye Lens from Oxidative Stress through Oxygen Regulation

  • Witold Karol Subczynski,
  • Marta Pasenkiewicz-Gierula and
  • Justyna Widomska

20 September 2023

Molecular oxygen is a primary oxidant that is involved in the formation of active oxygen species and in the oxidation of lipids and proteins. Thus, controlling oxygen partial pressure (concentration) in the human organism, tissues, and organs can be...

  • Article
  • Open Access
4 Citations
2,978 Views
27 Pages

20 September 2023

The degeneration of dopamine (DA) neurons is known to be associated with defects in mitochondrial biogenesis caused by aging, environmental factors, or mutations in genes, leading to Parkinson’s disease (PD). As PD has not yet been successfully...

  • Article
  • Open Access
33 Citations
4,115 Views
19 Pages

A Pectic Polysaccharide from Codonopsis pilosula Alleviates Inflammatory Response and Oxidative Stress of Aging Mice via Modulating Intestinal Microbiota-Related Gut–Liver Axis

  • Yuanfeng Zou,
  • Hong Yan,
  • Cenyu Li,
  • Fang Wen,
  • Xiaoping Jize,
  • Chaowen Zhang,
  • Siqi Liu,
  • Yuzhe Zhao,
  • Yuping Fu and
  • Lixia Li
  • + 5 authors

19 September 2023

Aging is a biological process that leads to the progressive deterioration and loss of physiological functions in the human body and results in an increase in morbidity and mortality, and aging-related disease is a major global problem that poses a se...

  • Review
  • Open Access
11 Citations
6,848 Views
12 Pages

Methanethiol: A Scent Mark of Dysregulated Sulfur Metabolism in Cancer

  • Thilo Magnus Philipp,
  • Anne Sophie Scheller,
  • Niklas Krafczyk,
  • Lars-Oliver Klotz and
  • Holger Steinbrenner

19 September 2023

In order to cope with increased demands for energy and metabolites as well as to enhance stress resilience, tumor cells develop various metabolic adaptations, representing a hallmark of cancer. In this regard, the dysregulation of sulfur metabolism t...

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Antioxidants - ISSN 2076-3921