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Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery

1
Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO 80203, USA
2
Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80203, USA
3
Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO 80203, USA
4
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
5
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80203, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(7), 173; https://doi.org/10.3390/brainsci9070173
Received: 28 June 2019 / Revised: 17 July 2019 / Accepted: 18 July 2019 / Published: 20 July 2019
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PDF [256 KB, uploaded 20 July 2019]

Abstract

Observations using invasive neural recordings from patient populations undergoing neurosurgical interventions have led to critical breakthroughs in our understanding of human neural circuit function and malfunction. The opportunity to interact with patients during neurophysiological mapping allowed for early insights in functional localization to improve surgical outcomes, but has since expanded into exploring fundamental aspects of human cognition including reward processing, language, the storage and retrieval of memory, decision-making, as well as sensory and motor processing. The increasing use of chronic neuromodulation, via deep brain stimulation, for a spectrum of neurological and psychiatric conditions has in tandem led to increased opportunity for linking theories of cognitive processing and neural circuit function. Our purpose here is to motivate the neuroscience and neurosurgical community to capitalize on the opportunities that this next decade will bring. To this end, we will highlight recent studies that have successfully leveraged invasive recordings during deep brain stimulation surgery to advance our understanding of human cognition with an emphasis on reward processing, improving clinical outcomes, and informing advances in neuromodulatory interventions. View Full-Text
Keywords: deep brain stimulation; electrophysiology; intraoperative; human cognition; single-units; local field potentials; functional neurosurgery deep brain stimulation; electrophysiology; intraoperative; human cognition; single-units; local field potentials; functional neurosurgery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tekriwal, A.; Afshar, N.M.; Santiago-Moreno, J.; Kuijper, F.M.; Kern, D.S.; Halpern, C.H.; Felsen, G.; Thompson, J.A. Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery. Brain Sci. 2019, 9, 173.

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