Mixed Small Vessel Disease in a Patient with Dementia with Lewy Bodies
AbstractBackground: Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid in small/medium size brain vessels, and may coexist with Alzheimer’s disease or dementia with Lewy bodies (DLB). We describe a patient with a clinical diagnosis of DLB and imaging/biochemical characteristics suggestive of mixed small vessel disease (both CAA and non-amyloid microangiopathy). Methods: Clinical evaluation according to recent diagnostic criteria, magnetic resonance imaging, dopamine-transporter scan (DAT-scan) and cerebrospinal fluid (CSF) analysis for dementia biomarkers were all performed. Results: The patient is a 71-year-old male, fulfilling criteria for probable DLB, with a positive DAT-scan, but with multiple microbleeds in a cortical-subcortical location suggestive of CAA, some microbleeds in deep brain nuclei suggestive of non-amyloid microangiopathy and abnormal levels of only amyloid-beta (Aβ42) in CSF. Conclusion: Coexistent mixed vascular and neurodegenerative disorders are frequent in older subjects with dementia and each one of the underlying pathologies may contribute to, or modify the clinical presentation. View Full-Text
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Paraskevas, G.P.; Constantinides, V.C.; Pyrgelis, E.-S.; Kapaki, E. Mixed Small Vessel Disease in a Patient with Dementia with Lewy Bodies. Brain Sci. 2019, 9, 159.
Paraskevas GP, Constantinides VC, Pyrgelis E-S, Kapaki E. Mixed Small Vessel Disease in a Patient with Dementia with Lewy Bodies. Brain Sciences. 2019; 9(7):159.Chicago/Turabian Style
Paraskevas, George P.; Constantinides, Vasilios C.; Pyrgelis, Efstratios-Stylianos; Kapaki, Elisabeth. 2019. "Mixed Small Vessel Disease in a Patient with Dementia with Lewy Bodies." Brain Sci. 9, no. 7: 159.
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