Next Article in Journal
Corticotropin Releasing Factor Type 1 and 2 Receptor Signaling in the Medial Prefrontal Cortex Modulates Binge-Like Ethanol Consumption in C57BL/6J Mice
Next Article in Special Issue
Using Dual-Site Transcranial Magnetic Stimulation to Probe Connectivity between the Dorsolateral Prefrontal Cortex and Ipsilateral Primary Motor Cortex in Humans
Previous Article in Journal
Domain-Specific Expectations in Music Segmentation
Previous Article in Special Issue
Effect of a Mental Stimulation Program of Computer and Internet Learning on Cognitive Functions and Wellbeing in Older Community-Dwelling Mexicans
Open AccessArticle

White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups

1
Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
2
Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40508, USA
3
Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY 40508, USA
4
Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY 40508, USA
5
Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, USA
6
Department of Physiology, Colleges of Medicine, University of Kentucky, Lexington, KY 40536, USA
*
Authors to whom correspondence should be addressed.
Brain Sci. 2019, 9(7), 170; https://doi.org/10.3390/brainsci9070170
Received: 28 May 2019 / Revised: 7 July 2019 / Accepted: 16 July 2019 / Published: 19 July 2019
(This article belongs to the Collection Collection on Cognitive Neuroscience)
  |  
PDF [1260 KB, uploaded 23 July 2019]
  |  

Abstract

Subcortical white matter hyperintensities (WMHs) in the aging population frequently represent vascular injury that may lead to cognitive impairment. WMH progression is well described, but the factors underlying WMH regression remain poorly understood. A sample of 351 participants from the Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI2) was explored who had WMH volumetric quantification, structural brain measures, and cognitive measures (memory and executive function) at baseline and after approximately 2 years. Selected participants were categorized into three groups based on WMH change over time, including those that demonstrated regression (n = 96; 25.5%), stability (n = 72; 19.1%), and progression (n = 209; 55.4%). There were no significant differences in age, education, sex, or cognitive status between groups. Analysis of variance demonstrated significant differences in atrophy between the progression and both regression (p = 0.004) and stable groups (p = 0.012). Memory assessments improved over time in the regression and stable groups but declined in the progression group (p = 0.003; p = 0.018). WMH regression is associated with decreased brain atrophy and improvement in memory performance over two years compared to those with WMH progression, in whom memory and brain atrophy worsened. These data suggest that WMHs are dynamic and associated with changes in atrophy and cognition. View Full-Text
Keywords: white matter hyperintensities; WMH regression; WMH progression; Stable WMH; ADNI, brain atrophy, cognition white matter hyperintensities; WMH regression; WMH progression; Stable WMH; ADNI, brain atrophy, cognition
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Al-Janabi, O.M.; Bauer, C.E.; Goldstein, L.B.; Murphy, R.R.; Bahrani, A.A.; Smith, C.D.; Wilcock, D.M.; Gold, B.T.; Jicha, G.A. White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups. Brain Sci. 2019, 9, 170.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top