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Brain Sciences, Volume 12, Issue 6

2022 June - 128 articles

Cover Story: The Asymmetric Laplace Gaussian (ALG) distribution is a four-parametric statistical model emerging as the convolution of well-known Laplacian and Gaussian distributions. ALG presents a comprehensive statistical model of human brain inhibition distributions and enables psychiatrists and clinicians to categorize a spectrum of clinical conditions in terms of their statistical features. VIew this paper
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Articles (128)

  • Review
  • Open Access
20 Citations
5,802 Views
15 Pages

Surpass Evolve Flow Diverter for the Treatment of Intracranial Aneurysm: A Systematic Review

  • Rania Issa,
  • Zahrah Al-Homedi,
  • Dawood Hasan Syed,
  • Waseem Aziz and
  • Basem Al-Omari

Purpose: This systematic review aims to summarize the evidence investigating the effectiveness and safety of the Surpass Evolve-Flow Diverter (SE-FD) to treat brain aneurysms. Method: We searched MEDLINE, EMBASE, CINAHL, Web of Science, and Cochrane...

  • Article
  • Open Access
5 Citations
3,401 Views
19 Pages

Source Localization of Audiovisual Multisensory Neural Generators in Young Adults with Attention-Deficit/Hyperactivity Disorder

  • Heather S. McCracken,
  • Bernadette A. Murphy,
  • Ushani Ambalavanar,
  • Cheryl M. Glazebrook and
  • Paul C. Yielder

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that exhibits unique neurological and behavioural characteristics. Our previous work using event-related potentials demonstrated that adults with ADHD process audiovisua...

  • Review
  • Open Access
55 Citations
8,996 Views
10 Pages

Cognitive function is affected by low pressure and hypoxia in high-altitude environments, and is regulated by altitude and exposure time. With the economic development in the Qinghai-Tibet Plateau, the increase in work and study activities, as well a...

  • Article
  • Open Access
12 Citations
3,771 Views
10 Pages

Unexpected Effect of IL-1β on the Function of GABAA Receptors in Pediatric Focal Cortical Dysplasia

  • Veronica Alfano,
  • Alessia Romagnolo,
  • James D. Mills,
  • Pierangelo Cifelli,
  • Alessandro Gaeta,
  • Alessandra Morano,
  • Angelika Mühlebner,
  • Eleonora Aronica,
  • Eleonora Palma and
  • Gabriele Ruffolo

Focal cortical dysplasia (FCD) type II is an epileptogenic malformation of the neocortex, as well as a leading cause of drug-resistant focal epilepsy in children and young adults. The synaptic dysfunctions leading to intractable seizures in this dise...

  • Article
  • Open Access
3 Citations
3,678 Views
16 Pages

No Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders: A Retrospective Study

  • Daniela Caldirola,
  • Tatiana Torti,
  • Francesco Cuniberti,
  • Silvia Daccò,
  • Alessandra Alciati,
  • Koen Schruers,
  • Giovanni Martinotti,
  • Domenico De Berardis and
  • Giampaolo Perna

Background: We investigated, for the first time, whether there are any sex differences in retrospective self-reported childhood maltreatment (CM) in Italian adult patients with major depressive disorder (MDD) or bipolar disorder (BD). Furthermore, th...

  • Article
  • Open Access
29 Citations
3,317 Views
9 Pages

The Prophylactic and Multimodal Activity of Two Isatin Thiosemicarbazones against Alzheimer’s Disease In Vitro

  • Barbara Mavroidi,
  • Archontia Kaminari,
  • Dimitris Matiadis,
  • Dimitra Hadjipavlou-Litina,
  • Maria Pelecanou,
  • Athina Tzinia and
  • Marina Sagnou

Alzheimer’s disease (AD) is a multifactorial disorder strongly involving the formation of amyloid-β (Aβ) oligomers, which subsequently aggregate into the disease characteristic insoluble amyloid plaques, in addition to oxidative stres...

  • Article
  • Open Access
9 Citations
3,011 Views
11 Pages

Glioma peritumoral brain edema (GPTBE) is a frequent complication in patients with glioma. The severity of peritumoral edema endangers patients’ life and prognosis. However, there are still questions concerning the process of GPTBE formation an...

  • Case Report
  • Open Access
4 Citations
2,865 Views
8 Pages

High Myoinositol on Proton MR Spectroscopy Could Be a Potential Signature of Papillary Tumors of the Pineal Region—Case Report of Two Patients

  • Albert Pons-Escoda,
  • Juan Jose Sánchez Fernández,
  • Àlex de Vilalta,
  • Noemí Vidal and
  • Carles Majós

Papillary tumor of the pineal region (PTPR) is an uncommon entity in which a presurgical suspicion may be crucial for patient management. Maximal safe neurosurgical resection is of choice when PTPR is suspected, whereas non-surgical approaches can be...

  • Article
  • Open Access
14 Citations
4,661 Views
10 Pages

Objective: To investigate the relationship between post-stroke cognitive impairment (PSCI) and severe post-stroke dysphagia (PSD) and explore the risk factors related to PSCI combined with severe PSD. Methods: Data from patients were collated from th...

  • Article
  • Open Access
8 Citations
4,185 Views
10 Pages

Literature reviews appear to indicate that Music Therapy (MT) may instil a sense of empowerment and generate feelings of renewed self-confidence, distracting subjects who follow this type of intervention from negative thoughts and, generally, helping...

  • Article
  • Open Access
7 Citations
2,933 Views
11 Pages

IL-10 Gene Polymorphisms and IL-10 Serum Levels in Patients with Multiple Sclerosis in Lithuania

  • Ugne Masilionyte,
  • Greta Gedvilaite,
  • Kriste Kaikaryte,
  • Alvita Vilkeviciute,
  • Loresa Kriauciuniene,
  • Brigita Glebauskiene,
  • Renata Balnyte and
  • Rasa Liutkeviciene

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with features of demyelination and axonal degeneration at a young age. Genetic factors may play an important role in the development of multiple sclerosis. (1) Ob...

  • Protocol
  • Open Access
23 Citations
10,560 Views
13 Pages

Many research methods applied in molecular neuroscience require the collection of hippocampal samples, but a still poorly recognized problem is contamination with the choroid plexus during brain dissection. Because of a distinct pattern of gene expre...

  • Article
  • Open Access
6 Citations
4,192 Views
9 Pages

Brain Asymmetry and Its Effects on Gait Strategies in Hemiplegic Patients: New Rehabilitative Conceptions

  • Luca Vismara,
  • Veronica Cimolin,
  • Francesca Buffone,
  • Matteo Bigoni,
  • Daniela Clerici,
  • Serena Cerfoglio,
  • Manuela Galli and
  • Alessandro Mauro

Brain asymmetry is connected with motor performance, suggesting that hemiparetic patients have different gait patterns depending on the side of the lesion. This retrospective cohort study aims to further investigate the difference between right and l...

  • Article
  • Open Access
227 Citations
15,833 Views
15 Pages

SwinBTS: A Method for 3D Multimodal Brain Tumor Segmentation Using Swin Transformer

  • Yun Jiang,
  • Yuan Zhang,
  • Xin Lin,
  • Jinkun Dong,
  • Tongtong Cheng and
  • Jing Liang

Brain tumor semantic segmentation is a critical medical image processing work, which aids clinicians in diagnosing patients and determining the extent of lesions. Convolutional neural networks (CNNs) have demonstrated exceptional performance in compu...

  • Review
  • Open Access
9 Citations
4,335 Views
9 Pages

Maintaining normal gonadal axis hormone levels is important for improving the condition of male patients with pituitary adenoma. The current literature is somewhat divided on the results of evaluations of gonadal axis function in male patients with p...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,007 Views
13 Pages

Risky decision-making (RDM) is when individuals make choices based on the definite cognition for the probabilities of the options. Risk is embodied in the certainty of reward, and the smaller the probability is, the greater the risk will be. As simul...

  • Article
  • Open Access
3 Citations
5,052 Views
18 Pages

A Single Session of SMR-Neurofeedback Training Improves Selective Attention Emerging from a Dynamic Structuring of Brain–Heart Interplay

  • Pierre Bouny,
  • Laurent M. Arsac,
  • Yvan Pratviel,
  • Alexis Boffet,
  • Emma Touré Cuq and
  • Veronique Deschodt-Arsac

Research on sensorimotor rhythms (SMR) based on neurofeedback (NFb) emphasizes improvements in selective attention associated with SMR amplification. However, the long-term training proposed in most studies posed the question of acceptability, which...

  • Article
  • Open Access
14 Citations
4,776 Views
22 Pages

An embryo’s in-utero exposure to ethanol due to a mother’s alcohol drinking results in a range of deficits in the child that are collectively termed fetal alcohol spectrum disorders (FASDs). Prenatal ethanol exposure is one of the leading...

  • Review
  • Open Access
33 Citations
10,667 Views
19 Pages

Autism Spectrum Disorder and Fetal Alcohol Spectrum Disorder: A Literature Review

  • Barbara Carpita,
  • Lavinia Migli,
  • Ilaria Chiarantini,
  • Simone Battaglini,
  • Clara Montalbano,
  • Claudia Carmassi,
  • Ivan Mirko Cremone and
  • Liliana Dell’Osso

Fetal alcohol spectrum disorders (FASD) are a group of conditions associated with the effects of prenatal alcohol exposure and characterized by somatic and neuropsychological alterations. On the other hand, autism spectrum disorder (ASD) is character...

  • Article
  • Open Access
3 Citations
2,714 Views
11 Pages

Cerebrospinal fluid (CSF) human immunodeficiency virus-1 (HIV-1) ribonucleic acid (RNA) at higher levels than in plasma has been observed in HIV-1-positive patients and defined as CSF/plasma discordance or CSF escape. Discordance is particularly seen...

  • Review
  • Open Access
30 Citations
6,294 Views
18 Pages

Vitamin D Status and Parkinson’s Disease

  • Michela Barichella,
  • Federica Garrì,
  • Serena Caronni,
  • Carlotta Bolliri,
  • Luciano Zocchi,
  • Maria Carmela Macchione,
  • Valentina Ferri,
  • Daniela Calandrella and
  • Gianni Pezzoli

Parkinson’s disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms...

  • Article
  • Open Access
15 Citations
6,500 Views
24 Pages

Synaptic Dysfunction by Mutations in GRIN2B: Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification

  • Marwa Elmasri,
  • James S. Lotti,
  • Wajeeha Aziz,
  • Oliver G. Steele,
  • Eirini Karachaliou,
  • Kenji Sakimura,
  • Kasper B. Hansen and
  • Andrew C. Penn

GRIN2B mutations are rare but often associated with patients having severe neurodevelopmental disorders with varying range of symptoms such as intellectual disability, developmental delay and epilepsy. Patient symptoms likely arise from mutations dis...

  • Review
  • Open Access
64 Citations
15,486 Views
21 Pages

A Brief Introduction to Magnetoencephalography (MEG) and Its Clinical Applications

  • Alfred Lenin Fred,
  • Subbiahpillai Neelakantapillai Kumar,
  • Ajay Kumar Haridhas,
  • Sayantan Ghosh,
  • Harishita Purushothaman Bhuvana,
  • Wei Khang Jeremy Sim,
  • Vijayaragavan Vimalan,
  • Fredin Arun Sedly Givo,
  • Veikko Jousmäki and
  • Balázs Gulyás
  • + 1 author

Magnetoencephalography (MEG) plays a pivotal role in the diagnosis of brain disorders. In this review, we have investigated potential MEG applications for analysing brain disorders. The signal-to-noise ratio (SNRMEG = 2.2 db, SNREEG < 1 db) and sp...

  • Review
  • Open Access
6 Citations
4,407 Views
13 Pages

The mainstays of glioblastoma treatment, maximal safe resection, radiotherapy preserving neurological function, and temozolomide (TMZ) chemotherapy have not changed for the past 17 years despite significant advances in the understanding of the geneti...

  • Systematic Review
  • Open Access
17 Citations
5,733 Views
19 Pages

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

  • Qingqing Zhang,
  • Xiaoming Li,
  • Xinying Liu,
  • Shanshan Liu,
  • Mengzhu Zhang,
  • Yueling Liu,
  • Chunyan Zhu and
  • Kai Wang

(1) Background: Emotion regulation (ER) is regarded as a core treatment target for depression and other mental illnesses. In recent years, non-invasive brain stimulation (NIBS) has been extensively used as an intervention for mental illnesses, but th...

  • Feature Paper
  • Article
  • Open Access
2,351 Views
9 Pages

Topologic Efficiency Abnormalities of the Connectome in Asymptomatic Patients with Leukoaraiosis

  • Shun Yao,
  • Hong-Ying Zhang,
  • Ren Wang,
  • Ding-Sheng Cheng and
  • Jing Ye

Leukoaraiosis (LA) is commonly found in aging healthy people but its pathophysiological mechanism is not entirely known. Furthermore, there is still a lack of effective pathological biomarkers that can be used to identify the early stage of LA. Our a...

  • Communication
  • Open Access
6 Citations
3,034 Views
9 Pages

NAA/Glu Ratio Associated with Suicidal Ideation in Pilot Sample of Autistic Youth and Young Adults

  • Iska Moxon-Emre,
  • Paul E. Croarkin,
  • Zafiris J. Daskalakis,
  • Daniel M. Blumberger,
  • Rachael E. Lyon,
  • Hideaki Tani,
  • Peter Truong,
  • Meng-Chuan Lai,
  • Pushpal Desarkar and
  • Stephanie H. Ameis
  • + 2 authors

Suicidality is increased in autism spectrum disorder (ASD), yet effective interventions are lacking. Developing biologically based approaches for preventing and treating suicidality in ASD hinges on the identification of biomarkers of suicidal ideati...

  • Review
  • Open Access
10 Citations
6,036 Views
20 Pages

GABA, the main inhibitory neurotransmitter in the adult brain, depolarizes and excites immature neurons because of an initially higher intracellular chloride concentration [Cl]i due to the delayed expression of the chloride exporter KCC2 at birth. D...

  • Article
  • Open Access
25 Citations
5,911 Views
18 Pages

Selective Probiotic Treatment Positively Modulates the Microbiota–Gut–Brain Axis in the BTBR Mouse Model of Autism

  • Angela Pochakom,
  • Chunlong Mu,
  • Jong M. Rho,
  • Thomas A. Tompkins,
  • Shyamchand Mayengbam and
  • Jane Shearer

Recent studies have shown promise for the use of probiotics in modulating behaviour through the microbiota–gut–brain axis. In the present study, we assessed the impact of two probiotic strains in mitigating autism-related symptomology in...

  • Case Report
  • Open Access
2 Citations
4,164 Views
7 Pages

Neuronal Intranuclear Inclusion Disease-Related Neurotrophic Keratitis: A Case Report

  • Pei Liu,
  • Xuemei Lin,
  • Xiangjun Chen,
  • Tor Paaske Utheim,
  • Wei Gao,
  • Yan Yan and
  • Songdi Wu

Neuronal intranuclear inclusion disease (NIID) is a rare and slowly progressive neurodegenerative disease characterized by the presence of eosinophilic neuronal intranuclear inclusions. The clinical manifestations of NIID are diverse, and the most co...

  • Article
  • Open Access
9 Citations
2,445 Views
14 Pages

Purpose: Previous studies have found the neurodegeneration and atrophy of glaucomatous lateral geniculate nucleus (LGN), but the mechanism is still unknown. Circular RNA (circRNA) plays some important roles in physiological and pathological progressi...

  • Article
  • Open Access
20 Citations
6,973 Views
16 Pages

The progressive degradation of the nigrostriatal system leads to the development of Parkinson’s disease (PD). The synthesis of dopamine, the neurotransmitter of the nigrostriatal system, depends on the rate-limiting enzyme, tyrosine hydroxylase...

  • Article
  • Open Access
29 Citations
5,705 Views
12 Pages

Alcohol dependence is a common mental disease worldwide. Excessive alcohol consumption may lead to alcoholism and many complications. In severe cases, it will lead to inhibition and paralysis of the centers of the respiratory and circulatory systems...

  • Article
  • Open Access
23 Citations
4,212 Views
12 Pages

Executive Functions in Overweight and Obese Treatment-Seeking Patients: Cross-Sectional Data and Longitudinal Perspectives

  • Marco La Marra,
  • Ines Villano,
  • Ciro Rosario Ilardi,
  • Mario Carosella,
  • Maria Staiano,
  • Alessandro Iavarone,
  • Sergio Chieffi,
  • Giovanni Messina,
  • Rita Polito and
  • Antonietta Messina
  • + 5 authors

Background: Recent evidence suggests that a higher body weight may be linked to cognitive impairment in different domains involving executive/frontal functioning. However, challenging results are also available. Accordingly, our study was designed to...

  • Article
  • Open Access
9 Citations
3,078 Views
18 Pages

Development of Landmark Use for Navigation in Children: Effects of Age, Sex, Working Memory and Landmark Type

  • Anne H. van Hoogmoed,
  • Joost Wegman,
  • Danielle van den Brink and
  • Gabriele Janzen

The use of landmarks for navigation develops throughout childhood. Here, we examined the developmental trajectory of egocentric and allocentric navigation based on landmark information in an on-screen virtual environment in 39 5–6-year-olds, 43...

  • Review
  • Open Access
8 Citations
5,254 Views
12 Pages

Ultrasound-Mediated Bioeffects in Senescent Mice and Alzheimer’s Mouse Models

  • Matilde Balbi,
  • Daniel G. Blackmore,
  • Pranesh Padmanabhan and
  • Jürgen Götz

Ultrasound is routinely used for a wide range of diagnostic imaging applications. However, given that ultrasound can operate over a wide range of parameters that can all be modulated, its applicability extends far beyond the bioimaging field. In fact...

  • Article
  • Open Access
7 Citations
4,084 Views
12 Pages

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and the mechanism of its occurrence is still not fully elucidated. Accumulating evidence has suggested that the gut acts as a potential origin of PD pathogenesis. Re...

  • Case Report
  • Open Access
17 Citations
5,901 Views
12 Pages

Immune Checkpoint Inhibitor Associated Autoimmune Encephalitis, Rare and Novel Topic of Neuroimmunology: A Case Report and Review of the Literature

  • Yining Gao,
  • Jie Pan,
  • Dingding Shen,
  • Lisheng Peng,
  • Zhifeng Mao,
  • Chunxia Wang,
  • Huanyu Meng,
  • Qinming Zhou and
  • Sheng Chen

Immune checkpoint inhibitors (ICIs) are being used in patients with various advanced malignancies, and patient outcomes have improved considerably. Although ICIs can effectively treat tumors, 30–60% of patients experience immune-related adverse...

  • Case Report
  • Open Access
4 Citations
3,330 Views
8 Pages

Central venous catheters (CVCs) are increasingly used across specialties for invasive haemodynamic monitoring and for the delivery of fluids, medications, and nutritional support. Cerebral air embolism (CAE) is a rare but potentially fatal complicati...

  • Article
  • Open Access
3 Citations
7,366 Views
17 Pages

Is Reduced Visual Processing the Price of Language?

  • Christer Johansson and
  • Per Olav Folgerø

We suggest a later timeline for full language capabilities in Homo sapiens, placing the emergence of language over 200,000 years after the emergence of our species. The late Paleolithic period saw several significant changes. Homo sapiens became more...

  • Article
  • Open Access
24 Citations
4,654 Views
20 Pages

Homology Modelling, Molecular Docking and Molecular Dynamics Simulation Studies of CALMH1 against Secondary Metabolites of Bauhinia variegata to Treat Alzheimer’s Disease

  • Noopur Khare,
  • Sanjiv Kumar Maheshwari,
  • Syed Mohd Danish Rizvi,
  • Hind Muteb Albadrani,
  • Suliman A. Alsagaby,
  • Wael Alturaiki,
  • Danish Iqbal,
  • Qamar Zia,
  • Chiara Villa and
  • Abhimanyu Kumar Jha
  • + 2 authors

Calcium homeostasis modulator 1 (CALHM1) is a protein responsible for causing Alzheimer’s disease. In the absence of an experimentally designed protein molecule, homology modelling was performed. Through homology modelling, different CALHM1 mod...

  • Article
  • Open Access
3 Citations
3,458 Views
8 Pages

Background: To prevent the spread of coronavirus disease 2019 (COVID-19), hyperventilation (HV) activation has been avoided in electroencephalograms (EEGs) since April 2020. The influence of omitting HV in EEG on epilepsy diagnosis remains uncertain...

  • Article
  • Open Access
5 Citations
2,592 Views
18 Pages

Relationship of Neuropeptide S with Clinical and Metabolic Parameters of Patients during Rehabilitation Therapy for Schizophrenia

  • Agnieszka Markiewicz-Gospodarek,
  • Renata Markiewicz,
  • Beata Dobrowolska,
  • Ryszard Maciejewski and
  • Bartosz Łoza

Neuropeptide S (NPS) is a factor associated with the central regulation of body weight, stress, anxiety, learning, memory consolidation, wakefulness–sleep cycle, and anti-inflammatory and neuroplastic effects. Its stress-reducing, anti-anxiety,...

  • Article
  • Open Access
8 Citations
2,867 Views
12 Pages

Background: Glioblastoma (GBM) represents the most malignant glioma among astrocytomas and is a lethal form of brain cancer. Many RAB genes are involved in different cancers but RAB42 (Ras-associated binding 42) is seldom studied in GBM. Our study ai...

  • Article
  • Open Access
9 Citations
3,817 Views
19 Pages

Deep Brain Stimulation in Early-Stage Parkinson’s Disease: Patient Experience after 11 Years

  • Kaitlyn Stoehr,
  • Kian Pazira,
  • Kemberlee Bonnet,
  • David Schlundt,
  • David Charles and
  • Mallory Hacker

The deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot trial began more than a decade ago and remains the only investigation of DBS in mildly symptomatic patients. Patients completed therapeutic washouts biannually for t...

  • Article
  • Open Access
5 Citations
2,944 Views
16 Pages

In recent years, the increasing incidence of morbidity of brain stroke has made fast and accurate segmentation of lesion areas from brain MRI images important. With the development of deep learning, segmentation methods based on the computer have bec...

  • Article
  • Open Access
10 Citations
4,291 Views
14 Pages

Pain neuroscience education (PNE), a modern educational therapy, has been reported to be effective in pain control by reducing fear of movement. This study investigated the effects of additional PNE on a physical therapy rehabilitation protocol (PTRP...

  • Systematic Review
  • Open Access
26 Citations
5,518 Views
15 Pages

This paper aims to collect a compendium of randomized controlled trials (RCTs) exploring the effects of cognitively engaging physical activity (PA) interventions (basketball and floorball) on various domain-specific executive functions (EFs) in child...

  • Article
  • Open Access
6 Citations
3,623 Views
13 Pages

PTPRN Serves as a Prognostic Biomarker and Correlated with Immune Infiltrates in Low Grade Glioma

  • Peng Li,
  • Fanfan Chen,
  • Chen Yao,
  • Kezhou Zhu,
  • Bei Zhang and
  • Zelong Zheng

Background: Glioma is one of the most common malignant tumors of the central nervous system. Immune infiltration of tumor microenvironment was associated with overall survival in low grade glioma (LGG). However, effects of Tyrosine phosphatase recept...

  • Review
  • Open Access
17 Citations
12,671 Views
23 Pages

Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex beyond Motor Rehabilitation: A Review of the Current Evidence

  • Abdulhameed Tomeh,
  • Abdul Hanif Khan Yusof Khan,
  • Liyana Najwa Inche Mat,
  • Hamidon Basri and
  • Wan Aliaa Wan Sulaiman

Transcranial magnetic stimulation (TMS) has emerged as a novel technique to stimulate the human brain through the scalp. Over the years, identifying the optimal brain region and stimulation parameters has been a subject of debate in the literature on...

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Brain Sci. - ISSN 2076-3425