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Brain Sciences, Volume 12, Issue 5

May 2022 - 171 articles

Cover Story: Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraines that suggest abnormal brain energy metabolism and altered functional connectivity. This first-of-its-kind study aimed to investigate the whole migraine cycle using 1H-MRS and resting-state functional magnetic resonance imaging (fMRI). A migraine patient underwent 1H-MRS and resting-state fMRI for 21 consecutive days, regardless of whether he was in an interictal or ictal state. Metabolite ratios were assessed and compared to the intrinsic connectivity of subcortical brain areas. View this paper
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Articles (171)

  • Article
  • Open Access
13 Citations
3,195 Views
11 Pages

Wearing a Mask Shapes Interpersonal Space during COVID-19 Pandemic

  • Monica Biggio,
  • Ambra Bisio,
  • Valentina Bruno,
  • Francesca Garbarini and
  • Marco Bove

Social distancing norms have been promoted after the COVID-19 pandemic. In this work, we tested interpersonal space (IPS) in 107 subjects through a reaching-comfort distance estimation task. In the main experiment, subjects had to estimate the comfor...

  • Article
  • Open Access
10 Citations
3,075 Views
29 Pages

DIANA, a Process-Oriented Model of Human Auditory Word Recognition

  • Louis ten Bosch,
  • Lou Boves and
  • Mirjam Ernestus

This article presents DIANA, a new, process-oriented model of human auditory word recognition, which takes as its input the acoustic signal and can produce as its output word identifications and lexicality decisions, as well as reaction times. This m...

  • Article
  • Open Access
20 Citations
3,915 Views
18 Pages

Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke

  • Julien Clain,
  • David Couret,
  • Cynthia Planesse,
  • Pascale Krejbich-Trotot,
  • Olivier Meilhac,
  • Christian Lefebvre d’Hellencourt,
  • Wildriss Viranaicken and
  • Nicolas Diotel

Adiponectin exhibits pleiotropic effects, including anti-inflammatory, anti-apoptotic, anti-oxidant, and neuroprotective ones. Although some studies have documented brain expression in different rodent models of its receptors, AdipoR1 and AdipoR2, th...

  • Article
  • Open Access
4 Citations
3,464 Views
9 Pages

Long-Term Effects of Low-Level Blast Exposure and High-Caliber Weapons Use in Military Special Operators

  • Melissa Hunfalvay,
  • Nicholas P. Murray,
  • William T. Creel and
  • Frederick R. Carrick

Chronic low-level blast exposure has been linked with neurological alterations and traumatic brain injury (TBI) biomarkers. Impaired smooth-pursuit eye movements (SPEM) are often associated with TBI. The purpose of this study was to determine whether...

  • Article
  • Open Access
8 Citations
3,582 Views
13 Pages

Resting-State Neural-Activity Alterations in Subacute Aphasia after Stroke

  • Xiaohui Xie,
  • Ting Zhang,
  • Tongjian Bai,
  • Chen Chen,
  • Gong-Jun Ji,
  • Yanghua Tian,
  • Jinying Yang and
  • Kai Wang

Linguistic deficits are frequent symptoms among stroke survivors. The neural mechanism of post-stroke aphasia (PSA) was incompletely understood. Recently, resting-state functional magnetic resonance imaging (rs-fMRI) was widely used among several neu...

  • Article
  • Open Access
5 Citations
3,208 Views
12 Pages

Hippocampal Cytokine Release in Experimental Epileptogenesis—A Longitudinal In Vivo Microdialysis Study

  • Kai Siebenbrodt,
  • Vanessa Schütz,
  • Lara S. Costard,
  • Valentin Neubert,
  • Daniel Alvarez-Fischer,
  • Kerstin Seidel,
  • Bernd Schmeck,
  • Sven G. Meuth,
  • Felix Rosenow and
  • Sebastian Bauer

Background: Inflammation, particularly cytokine release, contributes to epileptogenesis by influencing the cerebral tissue remodeling and neuronal excitability that occurs after a precipitating epileptogenic insult. While several cytokines have been...

  • Article
  • Open Access
4 Citations
2,829 Views
13 Pages

Lower Prevalence of Chronic Pain in Manifest Huntington’s Disease: A Pilot Observational Study

  • Marianna Delussi,
  • Vittorio Sciruicchio,
  • Paolo Taurisano,
  • Francesca Morgante,
  • Elena Salvatore,
  • Isabella Pia Ferrara,
  • Livio Clemente,
  • Chiara Sorbera and
  • Marina de Tommaso

Pain is a minor problem compared with other Huntington Disease (HD) symptoms. Nevertheless, in HD it is poorly recognized and underestimated. So far, no study evaluated the presence of chronic pain in HD. The aim of this pilot study was to evaluate t...

  • Article
  • Open Access
11 Citations
2,682 Views
16 Pages

Objective: Although some meta-analyses have shown a correlation between a high neutrophil-to-lymphocyte ratio (NLR) and low survival in patients with gliomas, their conclusions are controversial, and no study has specifically explored the relationshi...

  • Article
  • Open Access
3 Citations
4,987 Views
10 Pages

Motor coordination abilities are related to cognitive abilities and academic achievement in children with neurodevelopmental disorders. However, the similarities and differences of these relationships in children with autism spectrum disorder (ASD) a...

  • Review
  • Open Access
26 Citations
4,885 Views
15 Pages

Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease

  • Yan Li,
  • Zhicheng Gu,
  • Shuxian Lin,
  • Lei Chen,
  • Valentina Dzreyan,
  • Moez Eid,
  • Svetlana Demyanenko and
  • Bin He

Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is increasingly becoming a global threat to the health and life of the elderly worldwide. Although there are some drugs clinically available for treating PD, these treat...

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Brain Sci. - ISSN 2076-3425