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Brain Sciences, Volume 12, Issue 5

2022 May - 171 articles

Cover Story: Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraines that suggest abnormal brain energy metabolism and altered functional connectivity. This first-of-its-kind study aimed to investigate the whole migraine cycle using 1H-MRS and resting-state functional magnetic resonance imaging (fMRI). A migraine patient underwent 1H-MRS and resting-state fMRI for 21 consecutive days, regardless of whether he was in an interictal or ictal state. Metabolite ratios were assessed and compared to the intrinsic connectivity of subcortical brain areas. View this paper
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Articles (171)

  • Article
  • Open Access
13 Citations
3,294 Views
11 Pages

Wearing a Mask Shapes Interpersonal Space during COVID-19 Pandemic

  • Monica Biggio,
  • Ambra Bisio,
  • Valentina Bruno,
  • Francesca Garbarini and
  • Marco Bove

Social distancing norms have been promoted after the COVID-19 pandemic. In this work, we tested interpersonal space (IPS) in 107 subjects through a reaching-comfort distance estimation task. In the main experiment, subjects had to estimate the comfor...

  • Article
  • Open Access
10 Citations
3,182 Views
29 Pages

DIANA, a Process-Oriented Model of Human Auditory Word Recognition

  • Louis ten Bosch,
  • Lou Boves and
  • Mirjam Ernestus

This article presents DIANA, a new, process-oriented model of human auditory word recognition, which takes as its input the acoustic signal and can produce as its output word identifications and lexicality decisions, as well as reaction times. This m...

  • Article
  • Open Access
21 Citations
4,041 Views
18 Pages

Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke

  • Julien Clain,
  • David Couret,
  • Cynthia Planesse,
  • Pascale Krejbich-Trotot,
  • Olivier Meilhac,
  • Christian Lefebvre d’Hellencourt,
  • Wildriss Viranaicken and
  • Nicolas Diotel

Adiponectin exhibits pleiotropic effects, including anti-inflammatory, anti-apoptotic, anti-oxidant, and neuroprotective ones. Although some studies have documented brain expression in different rodent models of its receptors, AdipoR1 and AdipoR2, th...

  • Article
  • Open Access
4 Citations
3,602 Views
9 Pages

Long-Term Effects of Low-Level Blast Exposure and High-Caliber Weapons Use in Military Special Operators

  • Melissa Hunfalvay,
  • Nicholas P. Murray,
  • William T. Creel and
  • Frederick R. Carrick

Chronic low-level blast exposure has been linked with neurological alterations and traumatic brain injury (TBI) biomarkers. Impaired smooth-pursuit eye movements (SPEM) are often associated with TBI. The purpose of this study was to determine whether...

  • Article
  • Open Access
8 Citations
3,702 Views
13 Pages

Resting-State Neural-Activity Alterations in Subacute Aphasia after Stroke

  • Xiaohui Xie,
  • Ting Zhang,
  • Tongjian Bai,
  • Chen Chen,
  • Gong-Jun Ji,
  • Yanghua Tian,
  • Jinying Yang and
  • Kai Wang

Linguistic deficits are frequent symptoms among stroke survivors. The neural mechanism of post-stroke aphasia (PSA) was incompletely understood. Recently, resting-state functional magnetic resonance imaging (rs-fMRI) was widely used among several neu...

  • Article
  • Open Access
5 Citations
3,319 Views
12 Pages

Hippocampal Cytokine Release in Experimental Epileptogenesis—A Longitudinal In Vivo Microdialysis Study

  • Kai Siebenbrodt,
  • Vanessa Schütz,
  • Lara S. Costard,
  • Valentin Neubert,
  • Daniel Alvarez-Fischer,
  • Kerstin Seidel,
  • Bernd Schmeck,
  • Sven G. Meuth,
  • Felix Rosenow and
  • Sebastian Bauer

Background: Inflammation, particularly cytokine release, contributes to epileptogenesis by influencing the cerebral tissue remodeling and neuronal excitability that occurs after a precipitating epileptogenic insult. While several cytokines have been...

  • Article
  • Open Access
4 Citations
2,888 Views
13 Pages

Lower Prevalence of Chronic Pain in Manifest Huntington’s Disease: A Pilot Observational Study

  • Marianna Delussi,
  • Vittorio Sciruicchio,
  • Paolo Taurisano,
  • Francesca Morgante,
  • Elena Salvatore,
  • Isabella Pia Ferrara,
  • Livio Clemente,
  • Chiara Sorbera and
  • Marina de Tommaso

Pain is a minor problem compared with other Huntington Disease (HD) symptoms. Nevertheless, in HD it is poorly recognized and underestimated. So far, no study evaluated the presence of chronic pain in HD. The aim of this pilot study was to evaluate t...

  • Article
  • Open Access
12 Citations
2,791 Views
16 Pages

Objective: Although some meta-analyses have shown a correlation between a high neutrophil-to-lymphocyte ratio (NLR) and low survival in patients with gliomas, their conclusions are controversial, and no study has specifically explored the relationshi...

  • Article
  • Open Access
3 Citations
5,161 Views
10 Pages

Motor coordination abilities are related to cognitive abilities and academic achievement in children with neurodevelopmental disorders. However, the similarities and differences of these relationships in children with autism spectrum disorder (ASD) a...

  • Review
  • Open Access
26 Citations
5,038 Views
15 Pages

Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease

  • Yan Li,
  • Zhicheng Gu,
  • Shuxian Lin,
  • Lei Chen,
  • Valentina Dzreyan,
  • Moez Eid,
  • Svetlana Demyanenko and
  • Bin He

Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is increasingly becoming a global threat to the health and life of the elderly worldwide. Although there are some drugs clinically available for treating PD, these treat...

  • Article
  • Open Access
11 Citations
4,310 Views
25 Pages

Models on L3/Ln acquisition differ with respect to how they envisage degree (holistic vs. selective transfer of the L1, L2 or both) and/or timing (initial stages vs. development) of how the influence of source languages unfolds. This study uses EEG/E...

  • Article
  • Open Access
3 Citations
2,842 Views
14 Pages

Interictal Heart Rate Variability as a Biomarker for Comorbid Depressive Disorders among People with Epilepsy

  • Guliqiemu Aimaier,
  • Kun Qian,
  • Zishuo Zheng,
  • Weifeng Peng,
  • Zhe Zhang,
  • Jing Ding and
  • Xin Wang

Depressive disorders are common among people with epilepsy (PwE). We here aimed to report an unbiased automatic classification of epilepsy comorbid depressive disorder cases via training a linear support vector machine (SVM) model using the intericta...

  • Article
  • Open Access
3 Citations
3,937 Views
14 Pages

Effects of Dynamic Sitting Exercise with Delayed Visual Feedback in the Early Post-Stroke Phase: A Pilot Double-Blinded Randomized Controlled Trial

  • Masahide Inoue,
  • Kazu Amimoto,
  • Kohei Shida,
  • Daisuke Sekine,
  • Daichi Hasegawa,
  • Kazuhiro Fukata,
  • Yuji Fujino,
  • Shigeru Makita and
  • Hidetoshi Takahashi

Sitting ability in the early post-stroke phase affects functional balance ability and other prognoses. We investigated whether dynamic sitting exercise with delayed visual feedback in the mediolateral and anteroposterior directions affected postural...

  • Case Report
  • Open Access
5 Citations
4,588 Views
12 Pages

A Novel Core Strengthening Intervention for Improving Trunk Function, Balance and Mobility after Stroke

  • Rakesh Pilkar,
  • Akhila Veerubhotla,
  • Oluwaseun Ibironke and
  • Naphtaly Ehrenberg

This paper a novel core-strengthening intervention (CSI) delivered using the AllCore360°, a device that targets trunk muscles through a systematic, high-intensity rotating-plank exercise. Three individuals (age: 61.7 ± 3.2 years; range: 58...

  • Article
  • Open Access
3 Citations
3,712 Views
13 Pages

Superordinate Categorization Based on the Perceptual Organization of Parts

  • Henning Tiedemann,
  • Filipp Schmidt and
  • Roland W. Fleming

Plants and animals are among the most behaviorally significant superordinate categories for humans. Visually assigning objects to such high-level classes is challenging because highly distinct items must be grouped together (e.g., chimpanzees and gec...

  • Article
  • Open Access
2 Citations
2,735 Views
9 Pages

Male predominance is a known feature of autism spectrum disorder (ASD). Although ASD mouse models can be useful for elucidating mechanisms underlying abnormal behaviors relevant to human ASD, suitable models to analyze sex differences in ASD pathogen...

  • Article
  • Open Access
5 Citations
4,552 Views
11 Pages

The role of social odors on human social interactions, including face evaluation, has been widely indicated. However, for nonsocial odors, there has not been a consistent conclusion. Therefore, this study aimed to verify the effect of suprathreshold...

  • Article
  • Open Access
10 Citations
4,149 Views
12 Pages

Background: Chronic ankle instability (CAI) is a common peripheral joint injury and there is still no consensus on the mechanisms. It is necessary to investigate electrocortical parameters to provide clinical insight into the functional alterations o...

  • Review
  • Open Access
10 Citations
5,789 Views
20 Pages

Depression is often associated with co-occurring neurocognitive deficits in executive function (EF), processing speed (PS) and emotion regulation (ER), which impact treatment response. Cognitive training targeting these capacities results in improved...

  • Article
  • Open Access
4 Citations
3,485 Views
15 Pages

TRP Family Genes Are Differently Expressed and Correlated with Immune Response in Glioma

  • Chaoyou Fang,
  • Houshi Xu,
  • Yibo Liu,
  • Chenkai Huang,
  • Xiaoyu Wang,
  • Zeyu Zhang,
  • Yuanzhi Xu,
  • Ling Yuan,
  • Anke Zhang and
  • Meiqing Lou
  • + 1 author

(1) Background: glioma is the most prevalent primary tumor of the human central nervous system and accompanies extremely poor prognosis in patients. The transient receptor potential (TRP) channels family consists of six different families, which are...

  • Article
  • Open Access
9 Citations
3,384 Views
8 Pages

Eye Tracking in Patients with Parkinson’s Disease Treated with Nabilone–Results of a Phase II, Placebo-Controlled, Double-Blind, Parallel-Group Pilot Study

  • Philipp Ellmerer,
  • Marina Peball,
  • Federico Carbone,
  • Marcel Ritter,
  • Beatrice Heim,
  • Kathrin Marini,
  • Dora Valent,
  • Florian Krismer,
  • Werner Poewe and
  • Klaus Seppi
  • + 1 author

The topic of the therapeutic use of cannabinoids in Parkinson’s disease (PD) is broadly discussed and frequently comes up in the outpatient clinic. So far, there are only a few randomized clinical trials assessing the effects of cannabinoids in...

  • Article
  • Open Access
4 Citations
2,557 Views
13 Pages

Prepulse inhibition (PPI) is the reduction in the acoustic startle reflex (ASR) when the startling stimulus (pulse) is preceded by a weaker, non-starting stimulus. This can be enhanced by facilitating selective attention to the prepulse against a noi...

  • Article
  • Open Access
15 Citations
3,737 Views
22 Pages

Background: Recording the calibration data of a brain–computer interface is a laborious process and is an unpleasant experience for the subjects. Domain adaptation is an effective technology to remedy the shortage of target data by leveraging r...

  • Article
  • Open Access
1 Citations
6,761 Views
25 Pages

Quantum Mechanical Aspects in the Pathophysiology of Neuropathic Pain

  • Sager Nawafleh,
  • Abdallah Barjas Qaswal,
  • Obada Alali,
  • Fuad Mohammed Zayed,
  • Ahmed Mahmoud Al-Azzam,
  • Khaled Al-Kharouf,
  • Mo’ath Bani Ali,
  • Moath Ahmad Albliwi,
  • Rawan Al-Hamarsheh and
  • Aiman Suleiman
  • + 7 authors

Neuropathic pain is a challenging complaint for patients and clinicians since there are no effective agents available to get satisfactory outcomes even though the pharmacological agents target reasonable pathophysiological mechanisms. This may indica...

  • Case Report
  • Open Access
1 Citations
7,360 Views
6 Pages

A Loop That Matters—An Unusual Case of Bow Hunter’s Syndrome

  • Bartosz Gajewski,
  • Ludomir Stefańczyk,
  • Jacek J. Rożniecki,
  • Mariusz Stasiołek and
  • Małgorzata Siger

Bow Hunter’s syndrome (BHS), also known as rotational vertebral artery occlusion (VAO), is a rare entity in which vertebral artery is reversibly compressed due to rotation or extension of the head, causing vertebrobasilar insufficiency. Because...

  • Review
  • Open Access
25 Citations
13,451 Views
15 Pages

Background: Acceptance and commitment therapy (ACT), a third-generation cognitive behavioral therapy (CBT), has proved its efficacy amidst various mental disorders. A growing body of studies has shown that ACT can improve obsessive-compulsive disorde...

  • Article
  • Open Access
4 Citations
3,057 Views
12 Pages

Antidepressant-like Effects of Renin Inhibitor Aliskiren in an Inflammatory Mouse Model of Depression

  • Sami I. Alzarea,
  • Hassan H. Alhassan,
  • Abdulaziz I. Alzarea,
  • Ziad H. Al-Oanzi and
  • Muhammad Afzal

Depression is considered a neuropsychic disease that has global prevalence and is associated with disability. The pathophysiology of depression is not well understood; however, emerging evidence has indicated that neuroinflammation could contribute t...

  • Article
  • Open Access
3 Citations
2,918 Views
11 Pages

Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS-STN: A Combined PET and Neuropsychological Study

  • Louise M. Jørgensen,
  • Tove Henriksen,
  • Skirmante Mardosiene,
  • Ottilia Wyon,
  • Sune H. Keller,
  • Bo Jespersen,
  • Gitte M. Knudsen and
  • Dea S. Stenbæk

Patients with Parkinson’s disease (PD) often suffer from non-motor symptoms, which may be caused by serotonergic dysfunction. Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non-motor symptoms. The aim of this s...

  • Article
  • Open Access
2 Citations
2,859 Views
24 Pages

Locus coeruleus (LC) neurons are controlled by glutamatergic inputs. Here, we studied in brain slices of neonatal rats NMDA and glutamate effects on phase-locked LC neuron spiking at ~1 Hz summating to ~0.2 s-lasting bell-shaped local field potential...

  • Article
  • Open Access
19 Citations
6,633 Views
23 Pages

Discerning Developmental Dyscalculia and Neurodevelopmental Models of Numerical Cognition in a Disadvantaged Educational Context

  • Flavia H. Santos,
  • Fabiana S. Ribeiro,
  • Ana Luiza Dias-Piovezana,
  • Caterina Primi,
  • Ann Dowker and
  • Michael von Aster

Developmental Dyscalculia (DD) signifies a failure in representing quantities, which impairs the performance of basic math operations and schooling achievement during childhood. The lack of specificity in assessment measures and respective cut-offs a...

  • Review
  • Open Access
24 Citations
5,436 Views
11 Pages

Glioblastoma are the most common primary malignant brain tumors with a highly infiltrative behavior. The extent of resection of the enhancing component has been shown to be correlated to survival. Recently, it has been proposed to move the resection...

  • Article
  • Open Access
24 Citations
5,172 Views
12 Pages

The Prevalence and Comorbidity of Tic Disorders and Obsessive-Compulsive Disorder in Chinese School Students Aged 6–16: A National Survey

  • Junjuan Yan,
  • Hu Deng,
  • Yongming Wang,
  • Xiaolin Wang,
  • Tengteng Fan,
  • Shijie Li,
  • Fang Wen,
  • Liping Yu,
  • Fang Wang and
  • Ying Li
  • + 4 authors

Background: Obsessive-compulsive disorder (OCD) and tic disorders (TDs) are closely related and considered to etiologically overlap. Both disorders are characterized by repetitive behaviors. TD and OCD often co-occur. The high comorbidity between OCD...

  • Article
  • Open Access
7 Citations
5,456 Views
19 Pages

Processing of an Audiobook in the Human Brain Is Shaped by Cultural Family Background

  • Maria Hakonen,
  • Arsi Ikäheimonen,
  • Annika Hultèn,
  • Janne Kauttonen,
  • Miika Koskinen,
  • Fa-Hsuan Lin,
  • Anastasia Lowe,
  • Mikko Sams and
  • Iiro P. Jääskeläinen

Perception of the same narrative can vary between individuals depending on a listener’s previous experiences. We studied whether and how cultural family background may shape the processing of an audiobook in the human brain. During functional m...

  • Article
  • Open Access
2 Citations
2,657 Views
12 Pages

Purpose: Neuropathic pain often originates from nerve injury or diseases of the somatosensory nervous system. However, its specific pathogenesis remains unclear. The requirement for excitatory synaptic plasticity in pain-related syndromes has been de...

  • Article
  • Open Access
3,040 Views
9 Pages

EEG Oscillations in Specific Frequency Bands Are Differently Coupled with Angular Joint Angle Kinematics during Rhythmic Passive Elbow Movement

  • Takako Suzuki,
  • Makoto Suzuki,
  • Kilchoon Cho,
  • Naoki Iso,
  • Takuhiro Okabe,
  • Toyohiro Hamaguchi,
  • Junichi Yamamoto and
  • Naohiko Kanemura

Rhythmic passive movements are often used during rehabilitation to improve physical functions. Previous studies have explored oscillatory activities in the sensorimotor cortex during active movements; however, the relationship between movement rhythm...

  • Article
  • Open Access
7 Citations
3,534 Views
9 Pages

Investigating the Migraine Cycle over 21 Consecutive Days Using Proton Magnetic Resonance Spectroscopy and Resting-State fMRI: A Pilot Study

  • Vera Filippi,
  • Ruth Steiger,
  • Vincent Beliveau,
  • Florian Frank,
  • Katharina Kaltseis,
  • Elke R. Gizewski and
  • Gregor Broessner

Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraine suggesting abnormal brain energy metabolism and altered functional connectivity. Proton magnetic resonance spectroscopy (1H-MRS) s...

  • Review
  • Open Access
6 Citations
9,215 Views
10 Pages

Cognitive control is essential to daily life. Task switching is a classical paradigm used to study cognitive control. Previous researchers have studied the representation of different abstract hierarchical rules in the prefrontal cortex and explored...

  • Article
  • Open Access
5 Citations
4,291 Views
9 Pages

A growing body of literature suggests a close link between olfaction and social expertise. The current study examines whether mentalizing skills are related to olfactory discrimination performance. In order to assess their mentalizing ability, 21 wom...

  • Article
  • Open Access
29 Citations
6,611 Views
10 Pages

The Role of Stress and Cognitive Absorption in Predicting Social Network Addiction

  • Loreta Cannito,
  • Eugenia Annunzi,
  • Caterina Viganò,
  • Bernardo Dell’Osso,
  • Matteo Vismara,
  • Pier Luigi Sacco,
  • Riccardo Palumbo and
  • Claudio D’Addario

Nowadays, the use of social networks (SNs) is pervasive and ubiquitous. Among other things, SNs have become a key resource for establishing and maintaining personal relationships, as further demonstrated by the emergence of the pandemic. However, eas...

  • Article
  • Open Access
13 Citations
6,624 Views
23 Pages

Recent research has suggested that working-memory training interventions may benefit children with developmental language disorder (DLD). The current study investigated a short and engaging adaptive working-memory intervention that targeted executive...

  • Article
  • Open Access
6 Citations
4,543 Views
10 Pages

Many concepts of the human personality are based on assumptions about underlying physiological processes. The most prominent example is probably the concept of extraversion introduced by H.J. Eysenck decades ago. However, more recent approaches also...

  • Article
  • Open Access
4 Citations
2,907 Views
10 Pages

Splenial Callosal Disconnection in Right Hemianopic Patients Induces Right Visual-Spatial Neglect

  • Francesco Tomaiuolo,
  • Giovanni Raffa,
  • Serena Campana,
  • Giada Garufi,
  • Stefano Lasaponara,
  • Loredana Voci,
  • Salvatore M. Cardali,
  • Antonino Germanò,
  • Fabrizio Doricchi and
  • Michael Petrides

Posterior cerebral artery (PCA) territory infarction involving occipital cortical damage can give rise to contralateral homonymous hemianopia. Here, we report two rare cases of patients with lesions in the left hemisphere PCA territory who developed...

  • Review
  • Open Access
5 Citations
4,642 Views
17 Pages

Action Selection and Motor Decision Making: Insights from Transcranial Magnetic Stimulation

  • Margherita Tecilla,
  • Andrea Guerra,
  • Lorenzo Rocchi,
  • Sara Määttä,
  • Matteo Bologna,
  • Maria Herrojo Ruiz,
  • Roberta Biundo,
  • Angelo Antonini and
  • Florinda Ferreri

In everyday life, goal-oriented motor behaviour relies on the estimation of the rewards/costs associated with alternative actions and on the appropriate selection of movements. Motor decision making is defined as the process by which a motor plan is...

  • Article
  • Open Access
1 Citations
3,049 Views
15 Pages

Brain science, an emerging, dynamic, multidisciplinary basic research field, is generating numerous valuable data. However, there are still several obstacles for the utilization of these data, such as data fragmentation, heterogeneity, availability,...

  • Article
  • Open Access
9 Citations
4,307 Views
13 Pages

Finger-Based Numerical Training Increases Sensorimotor Activation for Arithmetic in Children—An fNIRS Study

  • Christina Artemenko,
  • Silke Maria Wortha,
  • Thomas Dresler,
  • Mirjam Frey,
  • Roberta Barrocas,
  • Hans-Christoph Nuerk and
  • Korbinian Moeller

Most children use their fingers when learning to count and calculate. These sensorimotor experiences were argued to underlie reported behavioral associations of finger gnosis and counting with mathematical skills. On the neural level, associations we...

  • Article
  • Open Access
21 Citations
5,818 Views
13 Pages

The Effect of Task Performance and Partnership on Interpersonal Brain Synchrony during Cooperation

  • Shujin Zhou,
  • Yuxuan Zhang,
  • Yiwen Fu,
  • Lingling Wu,
  • Xiaodie Li,
  • Ningning Zhu,
  • Dan Li and
  • Mingming Zhang

Interpersonal brain synchrony (IBS) during cooperation has not been systematically investigated. To address this research gap, this study assessed neural synchrony during a cooperative jigsaw puzzle solving task using functional near-infrared spectro...

  • Case Report
  • Open Access
1 Citations
4,438 Views
8 Pages

Traumatic intracranial pseudoaneurysms (tIPAs) are a very rare pathology caused by blunt or penetrating head trauma. Diagnostic and therapeutic challenges of tIPAs are due to their unpredictable onset during the initial injury, or in a delayed manner...

  • Article
  • Open Access
8 Citations
6,143 Views
24 Pages

This study investigated the role of working memory capacity (WMC) in metaphoric and metonymic processing in Mandarin–English bilinguals’ minds. It also explored the neural correlations between metaphor and metonymy computations. We adopte...

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Brain Sci. - ISSN 2076-3425