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Brain Sciences, Volume 10, Issue 11

November 2020 - 135 articles

Cover Story: Pathological inclusions known as neurofibrilary tangles, composed of the microtubule associated protein tau (tau), are a typical pathological hallmark in Alzheimer’s and other neurodegenerative disorders. Tau pathology seems to spread between neurons as disease progresses, but the precise mechanisms underlying pathology spreading are still unclear. Nevertheless, pharmacological modulation of tau aggregation and spreading between neurons is a promising strategy for therapeutic intervention. View this paper
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Articles (135)

  • Communication
  • Open Access
20 Citations
3,370 Views
9 Pages

20 November 2020

Avenanthramides are a group of phenolic alkaloids that have been shown to have anti-inflammatory, anti-oxidant, anti-atherogenic, and vasodilation effects. The aim of the present study was to investigate the neuroprotective effect of avenanthramide-c...

  • Article
  • Open Access
17 Citations
4,566 Views
17 Pages

Association between Structural Connectivity and Generalized Cognitive Spectrum in Alzheimer’s Disease

  • Angela Lombardi,
  • Nicola Amoroso,
  • Domenico Diacono,
  • Alfonso Monaco,
  • Giancarlo Logroscino,
  • Roberto De Blasi,
  • Roberto Bellotti and
  • Sabina Tangaro

20 November 2020

Modeling disease progression through the cognitive scores has become an attractive challenge in the field of computational neuroscience due to its importance for early diagnosis of Alzheimer’s disease (AD). Several scores such as Alzheimer&rsqu...

  • Article
  • Open Access
17 Citations
5,046 Views
17 Pages

Effortful Control and Prefrontal Cortex Functioning in Children with Autism Spectrum Disorder: An fNIRS Study

  • Karthikeyan Krishnamurthy,
  • Michael K. Yeung,
  • Agnes S. Chan and
  • Yvonne M. Y. Han

20 November 2020

Effortful control (EC) is an important dimension of temperament, but is impaired in autism spectrum disorder (ASD). While EC is associated with the prefrontal cortex (PFC) functioning in typically developing (TD) children, it is unclear whether EC de...

  • Article
  • Open Access
8 Citations
3,359 Views
13 Pages

20 November 2020

Arterial ischemic stroke (AIS) in childhood is reported to occur more frequently in boys, which may lead to the assumption that the prevalence of post-stroke deficits is sex related. The present study aimed to evaluate sex-related differences in func...

  • Article
  • Open Access
29 Citations
4,873 Views
8 Pages

ColorViz, a New and Rapid Tool for Assessing Collateral Circulation during Stroke

  • Tommaso Verdolotti,
  • Fabio Pilato,
  • Simone Cottonaro,
  • Edoardo Monelli,
  • Carolina Giordano,
  • Pamela Guadalupi,
  • Massimo Benenati,
  • Antonia Ramaglia,
  • Alessandro Maria Costantini and
  • Andrea Alexandre
  • + 2 authors

20 November 2020

Prognosis of patients with acute ischemic stroke is strictly related to the patency and prominence of the collateral leptomeningeal pathways distal to the arterial occlusion. The gold standard for assessment of collateral circulation is conventional...

  • Case Report
  • Open Access
3 Citations
6,048 Views
13 Pages

Childhood ADHD and Early-Onset Bipolar Disorder Comorbidity: A Case Report

  • Paraskevi Tatsiopoulou,
  • Georgia-Nektaria Porfyri,
  • Eleni Bonti and
  • Ioannis Diakogiannis

20 November 2020

Introduction: Recent research has highlighted an increased rate of co-morbidity between the neurodevelopmental-behavioral disorder of attention deficit hyperactivity disorder (ADHD) and a variety of psychiatric disorders, such as mood disorders or bi...

  • Feature Paper
  • Article
  • Open Access
7 Citations
6,404 Views
13 Pages

Neuroimaging Markers for Studying Gulf-War Illness: Single-Subject Level Analytical Method Based on Machine Learning

  • Yi Guan,
  • Chia-Hsin Cheng,
  • Weifan Chen,
  • Yingqi Zhang,
  • Sophia Koo,
  • Maxine Krengel,
  • Patricia Janulewicz,
  • Rosemary Toomey,
  • Ehwa Yang and
  • Rafeeque Bhadelia
  • + 4 authors

20 November 2020

Gulf War illness (GWI) refers to the multitude of chronic health symptoms, spanning from fatigue, musculoskeletal pain, and neurological complaints to respiratory, gastrointestinal, and dermatologic symptoms experienced by about 250,000 GW veterans w...

  • Case Report
  • Open Access
15 Citations
4,120 Views
12 Pages

Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases

  • Gabriella Di Rosa,
  • Daniela Dicanio,
  • Antonio Gennaro Nicotera,
  • Patrizia Mondello,
  • Laura Cannavò and
  • Eloisa Gitto

20 November 2020

Neonatal seizures are the most common neurological emergency, and neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition and treatment. Here, we report on three newborns with NSE refractory to...

  • Article
  • Open Access
20 Citations
4,108 Views
10 Pages

Classification of Primary Cerebral Lymphoma and Glioblastoma Featuring Dynamic Susceptibility Contrast and Apparent Diffusion Coefficient

  • Felix Eisenhut,
  • Manuel A. Schmidt,
  • Florian Putz,
  • Sebastian Lettmaier,
  • Kilian Fröhlich,
  • Soheil Arinrad,
  • Roland Coras,
  • Hannes Luecking,
  • Stefan Lang and
  • Rainer Fietkau
  • + 1 author

20 November 2020

This study aimed to differentiate primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) via multimodal MRI featuring radiomic analysis. MRI data sets of patients with histological proven PCNSL and GBM were analyzed retrospectively. D...

  • Article
  • Open Access
24 Citations
5,825 Views
11 Pages

Vestibular Functioning in Children with Neurodevelopmental Disorders Using the Functional Head Impulse Test

  • Simona Caldani,
  • Moetez Baghdadi,
  • Ana Moscoso,
  • Eric Acquaviva,
  • Christophe-Loïc Gerard,
  • Vincenzo Marcelli,
  • Hugo Peyre,
  • Paola Atzori,
  • Richard Delorme and
  • Maria Pia Bucci

20 November 2020

Several studies in children with neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs), reading impairment, or attention deficit/hyperactive disorder (ADHD) pointed toward a potential dysfunction of the vestibular system, spe...

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Brain Sci. - ISSN 2076-3425