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Article

The Role of the T2–FLAIR Mismatch Sign as an Imaging Marker of IDH Status in a Mixed Population of Low- and High-Grade Gliomas

1
Department of Diagnostic Radiology, General University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41-334 Larissa, Greece
2
Department of Neurosurgery, General University Hospital of Larissa, 41-334 Larissa, Greece
3
Department of Diagnostic Radiology, General University Hospital of Larissa, 41-334 Larissa, Greece
4
Department of Neurology, General University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41-334 Larissa, Greece
5
Department of Neurosurgery, General University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41-334 Larissa, Greece
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(11), 874; https://doi.org/10.3390/brainsci10110874
Received: 20 October 2020 / Revised: 9 November 2020 / Accepted: 14 November 2020 / Published: 19 November 2020
(This article belongs to the Special Issue A Decade of Brain Sciences)
Our study evaluated the role of the T2–fluid-attenuated inversion recovery (FLAIR) mismatch sign in detecting isocitrate dehydrogenase (IDH) mutations based on a mixed sample of 24 patients with low- and high- grade gliomas. The association between the two was realized using univariate and multivariate logistic regression analysis. There was a substantial agreement between the two raters for the detection of the T2–FLAIR mismatch sign (Cohen’s kappa coefficient was 0.647). The T2–FLAIR mismatch sign when co-registered with the degree of tumor homogeneity were significant predictors of the IDH status (OR 29.642; 95% CI 1.73–509.15, p = 0.019). The probability of being IDH mutant in the presence of T2–FLAIR mismatch sign was as high as 92.9% (95% CI 63–99%). The sensitivity and specificity of T2–FLAIR mismatch sign in the detection of the IDH mutation was 88.9% and 86.7%, respectively. The T2–FLAIR mismatch sign may be an easy to use and helpful tool in recognizing IDH mutant patients, particularly if formal IDH testing is not available. We suggest that the adoption of a protocol based on imaging and histological data for optimal glioma characterization could be very helpful. View Full-Text
Keywords: T2–FLAIR mismatch sign; glioma; diagnosis; prediction T2–FLAIR mismatch sign; glioma; diagnosis; prediction
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MDPI and ACS Style

Kapsalaki, E.Z.; Brotis, A.G.; Tsikrika, A.; Tzerefos, C.; Paschalis, T.; Dardiotis, E.; Fountas, K.N. The Role of the T2–FLAIR Mismatch Sign as an Imaging Marker of IDH Status in a Mixed Population of Low- and High-Grade Gliomas. Brain Sci. 2020, 10, 874. https://doi.org/10.3390/brainsci10110874

AMA Style

Kapsalaki EZ, Brotis AG, Tsikrika A, Tzerefos C, Paschalis T, Dardiotis E, Fountas KN. The Role of the T2–FLAIR Mismatch Sign as an Imaging Marker of IDH Status in a Mixed Population of Low- and High-Grade Gliomas. Brain Sciences. 2020; 10(11):874. https://doi.org/10.3390/brainsci10110874

Chicago/Turabian Style

Kapsalaki, Eftychia Z., Alexandros G. Brotis, Alexandra Tsikrika, Christos Tzerefos, Thanos Paschalis, Efthymios Dardiotis, and Konstantinos N. Fountas 2020. "The Role of the T2–FLAIR Mismatch Sign as an Imaging Marker of IDH Status in a Mixed Population of Low- and High-Grade Gliomas" Brain Sciences 10, no. 11: 874. https://doi.org/10.3390/brainsci10110874

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