Table of Contents
Environments, Volume 5, Issue 9 (September 2018)
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Cover Story (view full-size image) Knowing how metals in living cells are partitioned between detoxified or sensitive fractions helps [...] Read more. Knowing how metals in living cells are partitioned between detoxified or sensitive fractions helps us better understand metal toxicity. Fractionation methods often involve heat treatment in order to isolate metals bound to cytosolic heat-stable peptides (HSP), such as metallothioneins; metals in this fraction are normally considered to have been ‘detoxified’. The present research revealed the presence of unsuspected metal forms in the HSP fraction, some of which are clearly not bound to metallothionein and may well not be detoxified. View this paper.