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Pathogens, Volume 10, Issue 12

2021 December - 122 articles

Cover Story: CMV belongs to the family of herpesviruses and causes life-long latent infection with episodes of reactivation. Murine CMV (MCMV) infection is used to investigate the crosstalk between CMV and the immune system. As opposed to other organs, MCMV establishes sustained lytic replication in the salivary glands (SGs), where it escapes CD8 T cell recognition. The infection is eventually controlled by CD4 T cells via pro-inflammatory cytokines, such as IFNγ. The reasons for this delayed control remain unclear. In this review, we discuss current knowledge regarding the dynamics and mechanisms of CD4 T-cell-mediated control and present a model in which CD4 T cells successively cluster and, through TCR-dependent IFNγ production, protect the tissue only locally, which could possibly explain the delayed immune control in the SGs. View this paper.
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Articles (122)

  • Article
  • Open Access
7 Citations
4,080 Views
17 Pages

Molecular Detection of Zoonotic and Non-Zoonotic Pathogens from Wild Boars and Their Ticks in the Corsican Wetlands

  • Baptiste Defaye,
  • Sara Moutailler,
  • Christian Pietri,
  • Clemence Galon,
  • Sébastien Grech-Angelini,
  • Vanina Pasqualini and
  • Yann Quilichini

20 December 2021

Corsica is the main French island in the Mediterranean Sea and has high levels of human and animal population movement. Among the local animal species, the wild boar is highly prevalent in the Corsican landscape and in the island’s traditions....

  • Article
  • Open Access
1 Citations
3,715 Views
12 Pages

20 December 2021

In recent years, porcine circovirus type 2d (PCV2d) has achieved a dominant position worldwide. Various PCV2d capsid-based vaccines have been used to alleviate concerns regarding the emergence of the variant. This study aimed to determine the dosage...

  • Article
  • Open Access
8 Citations
10,071 Views
10 Pages

Invasiveness of Escherichia coli Is Associated with an IncFII Plasmid

  • Lars Johannes Krall,
  • Sabrina Klein,
  • Sébastien Boutin,
  • Chia Ching Wu,
  • Aline Sähr,
  • Megan L. Stanifer,
  • Steeve Boulant,
  • Klaus Heeg,
  • Dennis Nurjadi and
  • Dagmar Hildebrand

20 December 2021

Escherichia coli is one of the most prevalent pathogens, causing a variety of infections including bloodstream infections. At the same time, it can be found as a commensal, being part of the intestinal microflora. While it is widely accepted that pat...

  • Article
  • Open Access
4 Citations
4,099 Views
14 Pages

The O-Ag Antibody Response to Francisella Is Distinct in Rodents and Higher Animals and Can Serve as a Correlate of Protection

  • Lauren E. Shoudy,
  • Prachi Namjoshi,
  • Gabriela Giordano,
  • Sudeep Kumar,
  • Jennifer D. Bowling,
  • Carl Gelhaus,
  • Eileen M. Barry,
  • Allan J. Hazlett,
  • Brian A. Hazlett and
  • Karsten R. O. Hazlett
  • + 3 authors

20 December 2021

Identifying correlates of protection (COPs) for vaccines against lethal human (Hu) pathogens, such as Francisella tularensis (Ft), is problematic, as clinical trials are currently untenable and the relevance of various animal models can be controvers...

  • Article
  • Open Access
10 Citations
5,757 Views
22 Pages

Clinical and Anatomopathological Evaluation of BALB/c Murine Models Infected with Isolates of Seven Pathogenic Sporothrix Species

  • Danielly Corrêa-Moreira,
  • Rodrigo C. Menezes,
  • Orazio Romeo,
  • Cintia M. Borba and
  • Manoel M. E. Oliveira

20 December 2021

Background: Sporotrichosis is a subcutaneous mycosis with worldwide distribution and caused by seven pathogenic species of Sporothrix genus: S. schenckii sensu stricto, S. brasiliensis, S. globosa and S. luriei (clinical clade), and the species S. me...

  • Article
  • Open Access
4 Citations
3,678 Views
25 Pages

Strategies and Patterns of Codon Bias in Molluscum Contagiosum Virus

  • Rahul Raveendran Nair,
  • Manikandan Mohan,
  • Gudepalya R. Rudramurthy,
  • Reethu Vivekanandam and
  • Panayampalli S. Satheshkumar

20 December 2021

Trends associated with codon usage in molluscum contagiosum virus (MCV) and factors governing the evolution of codon usage have not been investigated so far. In this study, attempts were made to decipher the codon usage trends and discover the major...

  • Article
  • Open Access
3 Citations
3,820 Views
14 Pages

20 December 2021

Porphyromonas gingivalis is the most common microorganism associated with adult periodontal disease, causing inflammation around the subgingival lesion. In this study, we investigated tryptophanyl tRNA synthase (WRS) production by THP-1 cells infecte...

  • Article
  • Open Access
12 Citations
6,063 Views
18 Pages

New Insights into Gastrointestinal and Pulmonary Parasitofauna of Wild Eurasian lynx (Lynx lynx) in the Harz Mountains of Germany

  • Lisa Segeritz,
  • Ole Anders,
  • Tomma Lilli Middelhoff,
  • Deliah Tamsyn Winterfeld,
  • Pavlo Maksimov,
  • Gereon Schares,
  • Franz Josef Conraths,
  • Anja Taubert and
  • Carlos Hermosilla

20 December 2021

The Eurasian lynx (Lynx lynx) represents an endangered wild felid species. In Germany, it currently occurs in three isolated populations in and around the Harz Mountains, the Palatinate Forest and the Bavarian Forest. Lynx parasitic infections affect...

  • Article
  • Open Access
13 Citations
5,806 Views
14 Pages

Genotyping and Antimicrobial Susceptibility of Clostridium perfringens and Clostridioides difficile in Camel Minced Meat

  • Mahmoud Fayez,
  • Waleed R. El-Ghareeb,
  • Ahmed Elmoslemany,
  • Saleem J. Alsunaini,
  • Mohamed Alkafafy,
  • Othman M. Alzahrani,
  • Samy F. Mahmoud and
  • Ibrahim Elsohaby

19 December 2021

The present study aimed to determine the occurrence, genotypes, and antimicrobial resistance of Clostridium perfringens (C. perfringens) and Clostridioides difficile (C. difficile) in camel minced meat samples collected from small butcher shops and s...

  • Article
  • Open Access
24 Citations
7,547 Views
10 Pages

Validation and Application of Skin RT-QuIC to Patients in China with Probable CJD

  • Kang Xiao,
  • Xuehua Yang,
  • Wei Zhou,
  • Cao Chen,
  • Qi Shi and
  • Xiaoping Dong

19 December 2021

The definite diagnosis of human sporadic Creutzfeldt–Jakob disease (sCJD) largely depends on postmortem neuropathology and PrPSc detection in the brain. The development of real-time quaking-induced conversion (RT-QuIC) of cerebrospinal fluid (C...

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Pathogens - ISSN 2076-0817