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Journal of Personalized Medicine, Volume 13, Issue 1

January 2023 - 160 articles

Cover Story: A total of 71 patients with measurable lesions were included, among which 46 patients had enough tissue for next-generation sequencing. The overall objective response rate (ORR) was 46.4%. ORR was significantly higher in mismatch repair (MMR)-deficient (dMMR) patients than in MMR-proficient (pMMR) patients, in patients with lymph node metastasis only than those with other metastasis sites, and in patients with an Eastern Cooperative Oncology Group performance status of 0 than with a PS of 1 or 2. The progression-free survival was significantly longer in patients with dMMR, lymph node metastasis only, PD-L1 combined positive score (CPS) ≥ 5, and CDH1 wild type. Several clinicopathological and molecular features are associated with anti-PD-1 treatment efficacy in Signet ring cell carcinoma (SRCC), which might be used to identify patients who can benefit most from these therapies. View this paper
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Articles (160)

  • Article
  • Open Access
2 Citations
2,601 Views
7 Pages

Blood Loss Following Open Posterior Spinal Fusion in Fractures: Cannulated vs. Solid Pedicle Screws

  • Pedram Rajabifard,
  • John Edward Cunningham,
  • Michael A. Johnson,
  • Henrik Constantin Bäcker and
  • Peter Turner

16 January 2023

We aim to delineate whether there is increased blood loss with the use of cannulated pedicle screws compared to solid pedicle screws in patients undergoing posterior spinal fusion. A single-centre retrospective case-control study was undertaken on pa...

  • Review
  • Open Access
1 Citations
5,623 Views
21 Pages

Direct Oral Anticoagulants for Stroke and Systemic Embolism Prevention in Patients with Left Ventricular Thrombus

  • Minerva Codruta Badescu,
  • Victorita Sorodoc,
  • Catalina Lionte,
  • Anca Ouatu,
  • Raluca Ecaterina Haliga,
  • Alexandru Dan Costache,
  • Oana Nicoleta Buliga-Finis,
  • Ioan Simon,
  • Laurentiu Sorodoc and
  • Irina-Iuliana Costache
  • + 1 author

14 January 2023

In recent years, direct oral anticoagulants (DOAC) have accumulated evidence of efficacy and safety in various clinical scenarios and are approved for a wide spectrum of indications. Still, they are currently used off-label for left ventricular throm...

  • Article
  • Open Access
1 Citations
2,409 Views
25 Pages

14 January 2023

Imaging and genetic studies have characterized biological risk factors contributing to specific reading disability (SRD). The current study aimed to apply this literature to a family of twins discordant for SRD and an older sibling with reading diffi...

  • Review
  • Open Access
7 Citations
4,662 Views
24 Pages

14 January 2023

In recent years, diabetes-associated breast cancer has become a significant clinical challenge. Diabetes is not only a risk factor for breast cancer but also worsens its prognosis. Patients with diabetes usually show hyperglycemia and hyperinsulinemi...

  • Article
  • Open Access
13 Citations
3,609 Views
13 Pages

The Prognostic Value of the GNRI in Patients with Stomach Cancer Undergoing Surgery

  • Qianqian Zhang,
  • Lilong Zhang,
  • Qi Jin,
  • Yongheng He,
  • Mingsheng Wu,
  • Hongxing Peng and
  • Yijin Li

13 January 2023

Malnutrition often induces an adverse prognosis in cancer surgery patients. The elderly nutrition risk index (GNRI) is an example of the objective indicators of nutrition-related risks. We performed a meta-analysis to thoroughly examine the evidence...

  • Review
  • Open Access
26 Citations
13,004 Views
14 Pages

Maternity Blues: A Narrative Review

  • Valentina Tosto,
  • Margherita Ceccobelli,
  • Emanuela Lucarini,
  • Alfonso Tortorella,
  • Sandro Gerli,
  • Fabio Parazzini and
  • Alessandro Favilli

13 January 2023

Puerperium is a period of great vulnerability for the woman, associated with intense physical and emotional changes. Maternity blues (MB), also known as baby blues, postnatal blues, or post-partum blues, include low mood and mild, transient, self-lim...

  • Article
  • Open Access
10 Citations
4,888 Views
12 Pages

A Deep Learning Method for Quantification of Femoral Head Necrosis Based on Routine Hip MRI for Improved Surgical Decision Making

  • Adrian C. Ruckli,
  • Andreas K. Nanavati,
  • Malin K. Meier,
  • Till D. Lerch,
  • Simon D. Steppacher,
  • Sébastian Vuilleumier,
  • Adam Boschung,
  • Nicolas Vuillemin,
  • Moritz Tannast and
  • Klaus A. Siebenrock
  • + 2 authors

12 January 2023

(1) Background: To evaluate the performance of a deep learning model to automatically segment femoral head necrosis (FHN) based on a standard 2D MRI sequence compared to manual segmentations for 3D quantification of FHN. (2) Methods: Twenty-six patie...

  • Article
  • Open Access
24 Citations
6,661 Views
13 Pages

12 January 2023

Given the popularity of social media and the growing presence of these tools in the daily lives of individuals, research about the elements that can be linked to their problematic use appears to be of great importance. The objective of this study was...

  • Article
  • Open Access
8 Citations
3,127 Views
15 Pages

Severe Burn Injury Significantly Alters the Gene Expression and m6A Methylation Tagging of mRNAs and lncRNAs in Human Skin

  • Yanqin Ran,
  • Zhuoxian Yan,
  • Mitao Huang,
  • Situo Zhou,
  • Fangqin Wu,
  • Mengna Wang,
  • Sifan Yang,
  • Pihong Zhang,
  • Xiaoyuan Huang and
  • Bimei Jiang
  • + 1 author

12 January 2023

N6-methyladenosine (m6A) modulates RNA metabolism and functions in cell differentiation, tissue development, and immune response. After acute burns, skin wounds are highly susceptible to infection and poor healing. However, our understanding of the e...

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J. Pers. Med. - ISSN 2075-4426Creative Common CC BY license