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Journal of Personalized Medicine, Volume 13, Issue 1

2023 January - 160 articles

Cover Story: A total of 71 patients with measurable lesions were included, among which 46 patients had enough tissue for next-generation sequencing. The overall objective response rate (ORR) was 46.4%. ORR was significantly higher in mismatch repair (MMR)-deficient (dMMR) patients than in MMR-proficient (pMMR) patients, in patients with lymph node metastasis only than those with other metastasis sites, and in patients with an Eastern Cooperative Oncology Group performance status of 0 than with a PS of 1 or 2. The progression-free survival was significantly longer in patients with dMMR, lymph node metastasis only, PD-L1 combined positive score (CPS) ≥ 5, and CDH1 wild type. Several clinicopathological and molecular features are associated with anti-PD-1 treatment efficacy in Signet ring cell carcinoma (SRCC), which might be used to identify patients who can benefit most from these therapies. View this paper
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Articles (160)

  • Article
  • Open Access
2 Citations
2,763 Views
7 Pages

Blood Loss Following Open Posterior Spinal Fusion in Fractures: Cannulated vs. Solid Pedicle Screws

  • Pedram Rajabifard,
  • John Edward Cunningham,
  • Michael A. Johnson,
  • Henrik Constantin Bäcker and
  • Peter Turner

16 January 2023

We aim to delineate whether there is increased blood loss with the use of cannulated pedicle screws compared to solid pedicle screws in patients undergoing posterior spinal fusion. A single-centre retrospective case-control study was undertaken on pa...

  • Review
  • Open Access
2 Citations
6,287 Views
21 Pages

Direct Oral Anticoagulants for Stroke and Systemic Embolism Prevention in Patients with Left Ventricular Thrombus

  • Minerva Codruta Badescu,
  • Victorita Sorodoc,
  • Catalina Lionte,
  • Anca Ouatu,
  • Raluca Ecaterina Haliga,
  • Alexandru Dan Costache,
  • Oana Nicoleta Buliga-Finis,
  • Ioan Simon,
  • Laurentiu Sorodoc and
  • Ciprian Rezus
  • + 1 author

14 January 2023

In recent years, direct oral anticoagulants (DOAC) have accumulated evidence of efficacy and safety in various clinical scenarios and are approved for a wide spectrum of indications. Still, they are currently used off-label for left ventricular throm...

  • Article
  • Open Access
1 Citations
2,582 Views
25 Pages

14 January 2023

Imaging and genetic studies have characterized biological risk factors contributing to specific reading disability (SRD). The current study aimed to apply this literature to a family of twins discordant for SRD and an older sibling with reading diffi...

  • Review
  • Open Access
8 Citations
5,252 Views
24 Pages

14 January 2023

In recent years, diabetes-associated breast cancer has become a significant clinical challenge. Diabetes is not only a risk factor for breast cancer but also worsens its prognosis. Patients with diabetes usually show hyperglycemia and hyperinsulinemi...

  • Article
  • Open Access
18 Citations
3,893 Views
13 Pages

The Prognostic Value of the GNRI in Patients with Stomach Cancer Undergoing Surgery

  • Qianqian Zhang,
  • Lilong Zhang,
  • Qi Jin,
  • Yongheng He,
  • Mingsheng Wu,
  • Hongxing Peng and
  • Yijin Li

13 January 2023

Malnutrition often induces an adverse prognosis in cancer surgery patients. The elderly nutrition risk index (GNRI) is an example of the objective indicators of nutrition-related risks. We performed a meta-analysis to thoroughly examine the evidence...

  • Review
  • Open Access
34 Citations
14,562 Views
14 Pages

Maternity Blues: A Narrative Review

  • Valentina Tosto,
  • Margherita Ceccobelli,
  • Emanuela Lucarini,
  • Alfonso Tortorella,
  • Sandro Gerli,
  • Fabio Parazzini and
  • Alessandro Favilli

13 January 2023

Puerperium is a period of great vulnerability for the woman, associated with intense physical and emotional changes. Maternity blues (MB), also known as baby blues, postnatal blues, or post-partum blues, include low mood and mild, transient, self-lim...

  • Article
  • Open Access
13 Citations
5,248 Views
12 Pages

A Deep Learning Method for Quantification of Femoral Head Necrosis Based on Routine Hip MRI for Improved Surgical Decision Making

  • Adrian C. Ruckli,
  • Andreas K. Nanavati,
  • Malin K. Meier,
  • Till D. Lerch,
  • Simon D. Steppacher,
  • Sébastian Vuilleumier,
  • Adam Boschung,
  • Nicolas Vuillemin,
  • Moritz Tannast and
  • Florian Schmaranzer
  • + 2 authors

12 January 2023

(1) Background: To evaluate the performance of a deep learning model to automatically segment femoral head necrosis (FHN) based on a standard 2D MRI sequence compared to manual segmentations for 3D quantification of FHN. (2) Methods: Twenty-six patie...

  • Article
  • Open Access
27 Citations
7,279 Views
13 Pages

12 January 2023

Given the popularity of social media and the growing presence of these tools in the daily lives of individuals, research about the elements that can be linked to their problematic use appears to be of great importance. The objective of this study was...

  • Article
  • Open Access
9 Citations
3,339 Views
15 Pages

Severe Burn Injury Significantly Alters the Gene Expression and m6A Methylation Tagging of mRNAs and lncRNAs in Human Skin

  • Yanqin Ran,
  • Zhuoxian Yan,
  • Mitao Huang,
  • Situo Zhou,
  • Fangqin Wu,
  • Mengna Wang,
  • Sifan Yang,
  • Pihong Zhang,
  • Xiaoyuan Huang and
  • Pengfei Liang
  • + 1 author

12 January 2023

N6-methyladenosine (m6A) modulates RNA metabolism and functions in cell differentiation, tissue development, and immune response. After acute burns, skin wounds are highly susceptible to infection and poor healing. However, our understanding of the e...

  • Article
  • Open Access
9 Citations
2,949 Views
12 Pages

Plasma Interleukin-6 Level Predicts the Risk of Arteriovenous Fistula Dysfunction in Patients Undergoing Maintenance Hemodialysis

  • Jihyun Baek,
  • Hyeyeon Lee,
  • Taeyoung Yang,
  • So-Young Lee,
  • Yang Gyun Kim,
  • Jin Sug Kim,
  • ShinYoung Ahn,
  • Kipyo Kim,
  • Seok Hui Kang and
  • Yu Ho Lee
  • + 3 authors

12 January 2023

Systemic inflammation has been proposed as a relevant factor of vascular remodeling and dysfunction. We aimed to identify circulating inflammatory biomarkers that could predict future arteriovenous fistula (AVF) dysfunction in patients undergoing hem...

  • Article
  • Open Access
1 Citations
2,897 Views
9 Pages

12 January 2023

Background: In patients with BD-IPMN, surgical indications have been focused on finding malignant lesions (HGD, high-grade dysplasia/IC, invasive carcinoma). The aim of this study was to compare the preoperative factors that distinguish HGD from LGD...

  • Technical Note
  • Open Access
14 Citations
2,272 Views
6 Pages

Plasma Electrolytic Polished Patient-Specific Orbital Implants in Clinical Use—A Technical Note

  • Lara Schorn,
  • Max Wilkat,
  • Julian Lommen,
  • Maria Borelli,
  • Sajjad Muhammad and
  • Majeed Rana

11 January 2023

This technical note describes the technique of plasma electrolytic polishing on orbital patient-specific implants and demonstrates clinical handling and use by the insertion of a plasma electrolytic polished orbital implant into a patient.

  • Case Report
  • Open Access
5 Citations
4,352 Views
7 Pages

MERRF Mutation A8344G in a Four-Generation Family without Central Nervous System Involvement: Clinical and Molecular Characterization

  • Michela Ripolone,
  • Simona Zanotti,
  • Laura Napoli,
  • Dario Ronchi,
  • Patrizia Ciscato,
  • Giacomo Pietro Comi,
  • Maurizio Moggio and
  • Monica Sciacco

11 January 2023

A 53-year-old man approached our Neuromuscular Unit following an incidental finding of hyperckemia. Similar to his mother who had died at the age of 77 years, he was diabetic and had a few lipomas. The patient’s two sisters, aged 60 and 50 year...

  • Article
  • Open Access
14 Citations
5,576 Views
18 Pages

Microglia-Derived Spp1 Promotes Pathological Retinal Neovascularization via Activating Endothelial Kit/Akt/mTOR Signaling

  • Qian Bai,
  • Xin Wang,
  • Hongxiang Yan,
  • Lishi Wen,
  • Ziyi Zhou,
  • Yating Ye,
  • Yutong Jing,
  • Yali Niu,
  • Liang Wang and
  • Jiaxing Sun
  • + 5 authors

11 January 2023

Pathological retinal neovascularization (RNV) is the main character of ischemic ocular diseases, which causes severe visual impairments. Though retinal microglia are well acknowledged to play important roles in both physiological and pathological ang...

  • Article
  • Open Access
5 Citations
3,358 Views
7 Pages

11 January 2023

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted interests and repetitive behaviors. While the symptoms of ASD are present from early childhood, there has...

  • Article
  • Open Access
6 Citations
3,135 Views
9 Pages

11 January 2023

Purpose: The failure rate for operative decompression in neurogenic thoracic outlet syndrome (NTOS) is high compared to more distal nerve compression syndromes, such as cubital or carpal tunnel syndrome. Herein, we aimed to determine if a more radica...

  • Article
  • Open Access
1 Citations
3,132 Views
10 Pages

11 January 2023

Reconstruction surgeries in the inguinal area are challenging for vascular surgeons, oncologists, orthopedists, and others. The pedicled sartorius flap is the most commonly used flap for reconstruction. The pedicled adductor longus is reported as a n...

  • Article
  • Open Access
7 Citations
2,714 Views
12 Pages

Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease

  • Weizhao Lin,
  • Mengchen Liu,
  • Xixin Wu,
  • Shandong Meng,
  • Kanghui Yu,
  • Huanhuan Su,
  • Quanhai Liang,
  • Feng Chen,
  • Jincheng Li and
  • Guihua Jiang
  • + 3 authors

11 January 2023

Background: In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known. Methods: Cerebral blood flow (CBF) information was collected from 37...

  • Review
  • Open Access
13 Citations
28,075 Views
17 Pages

Management of Hyponatremia in Heart Failure: Practical Considerations

  • Victoriţa Şorodoc,
  • Andreea Asaftei,
  • Gabriela Puha,
  • Alexandr Ceasovschih,
  • Cătălina Lionte,
  • Oana Sîrbu,
  • Cristina Bologa,
  • Raluca Ecaterina Haliga,
  • Mihai Constantin and
  • Laurenţiu Şorodoc
  • + 3 authors

10 January 2023

Hyponatremia is commonly encountered in the setting of heart failure, especially in decompensated, fluid-overloaded patients. The pathophysiology of hyponatremia in patients with heart failure is complex, including numerous mechanisms: increased acti...

  • Article
  • Open Access
16 Citations
2,952 Views
10 Pages

10 January 2023

Purpose: To compare the U-tube and cusp dynamic navigation system registration methods in the use of dental implant placement, and to assess the influence of the location of missing teeth on these registrations. Methods: 32 resin mandible models and...

  • Article
  • Open Access
35 Citations
10,874 Views
13 Pages

Epidemiology and Risk Factors of UTIs in Children—A Single-Center Observation

  • Maria Daniel,
  • Hanna Szymanik-Grzelak,
  • Janusz Sierdziński,
  • Edyta Podsiadły,
  • Magdalena Kowalewska-Młot and
  • Małgorzata Pańczyk-Tomaszewska

10 January 2023

Urinary tract infections (UTIs) are one of childhood’s most common bacterial infections. The study aimed to determine the clinical symptoms, laboratory tests, risk factors, and etiology of different UTIs in children admitted to pediatric hospit...

  • Article
  • Open Access
3 Citations
2,986 Views
10 Pages

Partial Two-Stage Exchange for Infected Total Hip Arthroplasty: A Treatment to Take into Account

  • Miguel Moreno-Romero,
  • Alejandro Ordas-Bayon,
  • Alejandro Gomez-Rice,
  • Miguel A. Ortega and
  • Basilio J. De La Torre Escuredo

10 January 2023

Introduction: Two-stage revision is the gold standard for chronic periprosthetic joint infection (PJI). The removal of well-fixed implants, especially the femoral component, can be extremely difficult and additional osteotomies may be needed, which i...

  • Review
  • Open Access
4 Citations
4,334 Views
10 Pages

10 January 2023

Esophageal pressure (Pes) monitoring is a minimally invasive advanced respiratory monitoring method with the potential to guide ventilation support management. Pes monitoring enables the separation of lung and chest wall mechanics and estimation of t...

  • Article
  • Open Access
6 Citations
3,429 Views
18 Pages

Alternatively Spliced Isoforms of MUC4 and ADAM12 as Biomarkers for Colorectal Cancer Metastasis

  • Saleh Althenayyan,
  • Mohammed H. AlMuhanna,
  • Abdulkareem AlAbdulrahman,
  • Bandar Alghanem,
  • Suliman A. Alsagaby,
  • Abdulaziz Alfahed,
  • Glowi Alasiri and
  • Mohammad Azhar Aziz

10 January 2023

There is a pertinent need to develop prognostic biomarkers for practicing predictive, preventive and personalized medicine (PPPM) in colorectal cancer metastasis. The analysis of isoform expression data governed by alternative splicing provides a hig...

  • Review
  • Open Access
2 Citations
3,740 Views
20 Pages

Imaging Features of Main Hepatic Resections: The Radiologist Challenging

  • Carmen Cutolo,
  • Roberta Fusco,
  • Igino Simonetti,
  • Federica De Muzio,
  • Francesca Grassi,
  • Piero Trovato,
  • Pierpaolo Palumbo,
  • Federico Bruno,
  • Nicola Maggialetti and
  • Vincenza Granata
  • + 9 authors

10 January 2023

Liver resection is still the most effective treatment of primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), and of metastatic disease, such as colorectal liver metastases. The type of liver resection (a...

  • Article
  • Open Access
2 Citations
2,542 Views
13 Pages

Non-Typical Clinical Presentation of COVID-19 Patients in Association with Disease Severity and Length of Hospital Stay

  • Alexandros Skourtis,
  • Konstantinos Ekmektzoglou,
  • Theodoros Xanthos,
  • Stella Stouraitou and
  • Nicoletta Iacovidou

10 January 2023

Background: This study aimed to investigate the incidence of non-typical symptoms in ambulatory patients with mild-to-moderate COVID-19 infection and their potential association with disease progression. Materials and methods: Data on the symptomatol...

  • Review
  • Open Access
10 Citations
8,079 Views
16 Pages

Insights into Personalised Medicine in Bronchiectasis

  • Clementine S. Fraser and
  • Ricardo J. José

10 January 2023

Bronchiectasis is a heterogenous disease with multiple aetiologies resulting in inflammation and dilatation of the airways with associated mucus production and chronic respiratory infection. The condition is being recognised ever more frequently as t...

  • Article
  • Open Access
3 Citations
2,567 Views
9 Pages

10 January 2023

Inpatient rehabilitation should be assessed to improve each functional domain in patients with brain tumor. However, no previous study has reported risk factors for unplanned transfer of this patient population to primary acute care units during a co...

  • Article
  • Open Access
3 Citations
5,974 Views
12 Pages

9 January 2023

Although the benefits of hand orthoses were shown in previous studies, they have not been able to establish themselves in clinical routines. With a focus on patient satisfaction, this study aimed to evaluate the latest generation of hand orthoses aft...

  • Article
  • Open Access
10 Citations
3,951 Views
26 Pages

9 January 2023

Traditional dental implant surgery has been challenged by the phenomenal progression in computer-assisted surgery (CAS) that we have been witnessing in recent years. Among the computer-aided technologies, computer-aided design and computer-aided manu...

  • Article
  • Open Access
2 Citations
2,378 Views
11 Pages

Increasing Trend in Violence-Related Trauma and Suicide Attempts among Pediatric Trauma Patients: A 6-Year Analysis of Trauma Mechanisms and the Effects of the COVID-19 Pandemic

  • Cecilia Maina,
  • Stefano Piero Bernardo Cioffi,
  • Michele Altomare,
  • Andrea Spota,
  • Francesco Virdis,
  • Roberto Bini,
  • Roberta Ragozzino,
  • Federica Renzi,
  • Elisa Reitano and
  • Stefania Cimbanassi
  • + 3 authors

9 January 2023

Background: Trauma is the leading cause of morbidity and mortality in the pediatric population. During the COVID-19 pandemic (COVID-19), different trends for pediatric trauma (PT) were described. This study aims to explore the trend over time of PT i...

  • Article
  • Open Access
8 Citations
4,278 Views
11 Pages

Recognition of Postoperative Cystography Features by Artificial Intelligence to Predict Recovery from Postprostatectomy Urinary Incontinence: A Rapid and Easy Way to Predict Functional Outcome

  • I-Hung Shao,
  • Hung-Cheng Kan,
  • Hung-Yi Chen,
  • Ying-Hsu Chang,
  • Liang-Kang Huang,
  • Yuan-Cheng Chu,
  • Po-Hung Lin,
  • Kai-Jie Yu,
  • Cheng-Keng Chuang and
  • Chun-Te Wu
  • + 1 author

8 January 2023

Purpose: Post-operative cystography has been used to predict the recovery of postprostatectomy urinary incontinence (PPI) in patients with localized prostate cancer. This study aimed to validate the predictive value of cystography for PPI and utilize...

  • Review
  • Open Access
38 Citations
5,725 Views
24 Pages

Three-Dimensional Accuracy and Stability of Personalized Implants in Orthognathic Surgery: A Systematic Review and a Meta-Analysis

  • Alexandru Diaconu,
  • Michael Boelstoft Holte,
  • Gabriele Berg-Beckhoff and
  • Else Marie Pinholt

7 January 2023

This systematic review aimed to determine the accuracy/stability of patient-specific osteosynthesis (PSI) in orthognathic surgery according to three-dimensional (3D) outcome analysis and in comparison to conventional osteosynthesis and computer-aided...

  • Article
  • Open Access
3 Citations
2,313 Views
8 Pages

FairEmbo Concept for Postpartum Hemorrhage: Evaluation of the Efficacy of Suture Fragment Compared with Gelatin Sponge Torpedo Embolization in a Post-Gravid Swine Model

  • Amandine Banata Gang-Ny,
  • Julien Panneau,
  • Pauline Brige,
  • Jean-François Hak,
  • Paul Habert,
  • Vincent Vidal,
  • Farouk Tradi and
  • Mathieu Di Bisceglie

7 January 2023

Background: Postpartum hemorrhage is the leading cause of maternal mortality in emerging countries. This study aims to evaluate the effectiveness and safety of uterine artery embolization (UAE) using suture fragment (FairEmbo concept) in a swine mode...

  • Article
  • Open Access
3 Citations
3,720 Views
11 Pages

Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis

  • Anastasiya Kazantseva,
  • Renata Enikeeva,
  • Zalina Takhirova,
  • Yuliya Davydova,
  • Rustam Mustafin,
  • Sergey Malykh,
  • Alexandra Karunas,
  • Alexander Kanapin and
  • Elza Khusnutdinova

6 January 2023

To date, multiple efforts have been made to use genome-wide association studies (GWAS) to untangle the genetic basis for SARS-CoV-2 infection susceptibility and severe COVID-19. However, data on the genetic-related effects of SARS-CoV-2 infection on...

  • Feature Paper
  • Article
  • Open Access
8 Citations
3,350 Views
12 Pages

Combining Clinical and Genetic Data to Predict Response to Fingolimod Treatment in Relapsing Remitting Multiple Sclerosis Patients: A Precision Medicine Approach

  • Laura Ferrè,
  • Ferdinando Clarelli,
  • Beatrice Pignolet,
  • Elisabetta Mascia,
  • Marco Frasca,
  • Silvia Santoro,
  • Melissa Sorosina,
  • Florence Bucciarelli,
  • Lucia Moiola and
  • Federica Esposito
  • + 5 authors

6 January 2023

A personalized approach is strongly advocated for treatment selection in Multiple Sclerosis patients due to the high number of available drugs. Machine learning methods proved to be valuable tools in the context of precision medicine. In the present...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,671 Views
10 Pages

5 January 2023

With the updated 2020 vancomycin therapeutic drug monitoring (TDM) guidelines suggesting a ratio of area under the curve over 24 h to a minimum inhibitory concentration (AUC24/MIC) as a target from the Infectious Diseases Society of America, an accur...

  • Article
  • Open Access
7 Citations
2,452 Views
9 Pages

Oral Health and Risk of Retinal Vascular Occlusions: A Nationwide Cohort Study

  • Yoonkyung Chang,
  • Sung-Hee Kim,
  • Jimin Jeon,
  • Tae-Jin Song and
  • Jinkwon Kim

5 January 2023

Retinal vascular occlusions are a common cause of visual loss. The association between oral health and the risk of retinal vascular occlusions remains unknown. We investigated whether oral health was associated with the risk of retinal vascular occlu...

  • Article
  • Open Access
3 Citations
2,054 Views
16 Pages

Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy

  • Michael Kenn,
  • Rudolf Karch,
  • Christian F. Singer,
  • Georg Dorffner and
  • Wolfgang Schreiner

5 January 2023

Evidence theory by Dempster-Shafer for determination of hormone receptor status in breast cancer samples was introduced in our previous paper. One major topic pointed out here is the link between pieces of evidence found from different origins. In th...

  • Article
  • Open Access
6 Citations
2,662 Views
12 Pages

Semi-Supervised Segmentation Framework for Gastrointestinal Lesion Diagnosis in Endoscopic Images

  • Zenebe Markos Lonseko,
  • Wenju Du,
  • Prince Ebenezer Adjei,
  • Chengsi Luo,
  • Dingcan Hu,
  • Tao Gan,
  • Linlin Zhu and
  • Nini Rao

5 January 2023

Background: Accurate gastrointestinal (GI) lesion segmentation is crucial in diagnosing digestive tract diseases. An automatic lesion segmentation in endoscopic images is vital to relieving physicians’ burden and improving the survival rate of...

  • Article
  • Open Access
24 Citations
3,801 Views
18 Pages

5 January 2023

(1) Background: Many co-infections of Mycobacterium tuberculosis (MTB) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have emerged since the occurrence of the SARS-CoV-2 pandemic. This study aims to design an effective preventive mu...

  • Article
  • Open Access
7 Citations
4,750 Views
10 Pages

4 January 2023

Background: Signet ring cell carcinoma (SRCC) is a specific type of gastric cancer. The clinicopathological and molecular characteristics that can be used to predict the response to anti-PD-1 therapy for these patients are still not clear. Methods: P...

  • Article
  • Open Access
1 Citations
2,789 Views
15 Pages

Stroke Risk in Young Women with Primary Dysmenorrhea: A Propensity-Score-Matched Retrospective Cohort Study

  • Chung-Hsin Yeh,
  • Fung-Chang Sung,
  • Chih-Hsin Muo,
  • Pao-Sheng Yen and
  • Chung Y. Hsu

4 January 2023

Background: Studies on strokes associated with dysmenorrhea are limited. We conducted a propensity-score-matched retrospective cohort study to assess the risk of stroke in women with primary dysmenorrhea (PD). Methods: From the claims data of one mil...

  • Review
  • Open Access
34 Citations
11,428 Views
16 Pages

4 January 2023

Interventions adopting augmented and virtual reality (AR/VR) modalities allow participants to explore and experience realistic scenarios, making them useful psycho-educational tools for mental illnesses. This scoping review aims to evaluate the effec...

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J. Pers. Med. - ISSN 2075-4426