Neurological Diseases: From Molecular Mechanisms to Clinical Practice
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".
Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 13759
Special Issue Editors
Interests: cerebral ischemia; neurotrauma; neurodegeneration; signaling pathways; epigenetic regulation; apoptosis; neuroprotection
2. Lab Stem Cells Technology, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 117997 Moscow, Russia
Interests: cerebral ischemia; stroke, trauma; mitochondrial traffic; neuroprotection; ischemic preconditioning; autophagy; aging; intercellular communication
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Special Issue Information
Dear Colleagues,
Numerous studies of the molecular mechanisms of stroke, neurodegenerative diseases and neurotrauma, and the search for their effective diagnostics and therapy in recent decades have yielded various results. The rate of mortality because of these multifactorial diseases is decreasing in developed countries. However, the increasing incidence of neurological diseases in young people together with the population’s aging, as well as discovery of new mutations that cause neurological disorders are not good indicators for the future. Unfortunately, effective methods of neuroprotection are lacking, including stroke treatment agents with proven efficacy, which could protect penumbra neurons and limit the propagation of pathology both in the acute and recovery periods. The available therapies reduce the neurodegeneration rate to a certain extent but cannot cure or significantly slow down a disease. Many suggested agents were found to protect nerve cells in vitro and in animal brain but were ineffective or caused unacceptable side effects in humans. To find effective neuroprotectors, a profound study of the molecular mechanisms of neurodegeneration and neuroprotection is needed. Between the initial processes leading to damage propagation and the final processes resulting in neurodegeneration or neuroprotection with brain tissue recovery lies a vast field of biochemical signaling connected with transcription and epigenetic mechanisms. This Special Issue on “Neurological Diseases: From Molecular Mechanisms to Clinical Practice” will collect reviews and original articles on new approaches at the preclinical, translational, and clinical levels of research, aiming to find promising strategies for treating neuropathologies.
Dr. Svetlana Viktorovna Demyanenko
Dr. Denis Silachev
Guest Editors
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Keywords
- acute brain injury
- neurodegenerative diseases
- neurotrauma
- de novo mutation
- orphan diseases
- disease models
- neuroprotection
- therapeutic strategies
- drug discovery
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