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Journal of Personalized Medicine, Volume 13, Issue 2

February 2023 - 214 articles

Cover Story: Many computational problems used in the analysis of single-cell transcriptomic data are inherently multi-objective and challenging to solve. Genetic algorithms, inspired by the process of biological evolution, are well-suited for multi-objective optimization problems and can produce an ensemble of solutions, known as Pareto optimal solutions. A recent study demonstrated that a multi-objective genetic algorithm (MOGA) can successfully cluster single-cell transcriptomes of synthetic and experimental datasets, outperforming existing single-objective clustering methods. Despite its stochastic nature, MOGA produces reproducible and stable clustering results. The running times of MOGA can be improved by code parallelization and predicted using a random forest model, making it practical for the clustering of large scRNA-seq datasets. View this paper
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Articles (214)

  • Systematic Review
  • Open Access
10 Citations
4,933 Views
20 Pages

20 February 2023

The correlation between the menstrual cycle and glucose control in type 1 diabetes has been the focus of several studies since the 1920s, but a few critical aspects made it particularly challenging to reach conclusive evidence. The aim of this system...

  • Article
  • Open Access
48 Citations
4,785 Views
13 Pages

20 February 2023

Background: Cardiovascular diseases (CVDs) are a leading cause of death worldwide. Deep learning methods have been widely used in the field of medical image analysis and have shown promising results in the diagnosis of CVDs. Methods: Experiments were...

  • Article
  • Open Access
3 Citations
4,199 Views
9 Pages

Monitoring Perfusion Index in Patients Presenting to the Emergency Department Due to Drug Use

  • Gabriela Raluca Grigorasi,
  • Mihaela Corlade-Andrei,
  • Irina Ciumanghel,
  • Ivona Sova,
  • Teofil Blaga,
  • Claudiu Carp and
  • Diana Cimpoesu

19 February 2023

(1) Background: The perfusion index (PI) represents the ratio between pulsatile blood flow and non-pulsatile blood flow in the peripheral tissue. (2) We aimed to investigate the blood pressure perfusion of tissues and organs in ethnobotanical, synthe...

  • Article
  • Open Access
2 Citations
2,895 Views
11 Pages

Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome

  • Laszlo Zavori,
  • Tihamer Molnar,
  • Reka Varnai,
  • Andrea Kanizsai,
  • Lajos Nagy,
  • Bence Vadkerti,
  • Balazs Szirmay,
  • Attila Schwarcz and
  • Peter Csecsei

19 February 2023

Long-COVID syndrome is associated with high healthcare costs, but its pathophysiology is not yet fully understood. Inflammation, renal impairment or disturbance of the NO system emerge as potential pathogenetic factors. We aimed to investigate the re...

  • Review
  • Open Access
4 Citations
4,809 Views
18 Pages

19 February 2023

Functional magnetic resonance imaging (fMRI) is among the newest techniques of advanced neuroimaging that offer the opportunity for neuroradiologists, neurophysiologists, neuro-oncologists, and neurosurgeons to pre-operatively plan and manage differe...

  • Review
  • Open Access
24 Citations
6,408 Views
16 Pages

The Role of Molecular Imaging in Personalized Medicine

  • Suliman Salih,
  • Aisyah Elliyanti,
  • Ajnas Alkatheeri,
  • Fatima AlYafei,
  • Bashayer Almarri and
  • Hasina Khan

19 February 2023

The concept of personalized medicine refers to the tailoring of medical treatment to each patient’s unique characteristics. Scientific advancements have led to a better understanding of how a person’s unique molecular and genetic profile...

  • Article
  • Open Access
7 Citations
2,563 Views
10 Pages

19 February 2023

Background: An unintended consequence following lumbar fusion is the development of adjacent segment disease (ASD). Oblique lumbar interbody fusion combined with posterior decompression (OLIF-PD) is another feasible option for ASD, and there is no li...

  • Article
  • Open Access
13 Citations
2,639 Views
13 Pages

Identification of Immune-Related Risk Genes in Osteoarthritis Based on Bioinformatics Analysis and Machine Learning

  • Jintao Xu,
  • Kai Chen,
  • Yaohui Yu,
  • Yishu Wang,
  • Yi Zhu,
  • Xiangjie Zou and
  • Yiqiu Jiang

19 February 2023

In this research, we aimed to perform a comprehensive bioinformatic analysis of immune cell infiltration in osteoarthritic cartilage and synovium and identify potential risk genes. Datasets were downloaded from the Gene Expression Omnibus database. W...

  • Review
  • Open Access
45 Citations
8,849 Views
18 Pages

Pulmonary Vascular Remodeling in Pulmonary Hypertension

  • Zhuangzhuang Jia,
  • Shuai Wang,
  • Haifeng Yan,
  • Yawen Cao,
  • Xuan Zhang,
  • Lin Wang,
  • Zeyu Zhang,
  • Shanshan Lin,
  • Xianliang Wang and
  • Jingyuan Mao

19 February 2023

Pulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia. Pulmonary vascular remodeling consists of the proliferation and phen...

  • Article
  • Open Access
1 Citations
3,280 Views
13 Pages

19 February 2023

Background: The Advanced Breast Cancer Alliance conducted a nationwide investigation to understand the current situation of the diagnosis and treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) patient...

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J. Pers. Med. - ISSN 2075-4426Creative Common CC BY license