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Diagnostics, Volume 9, Issue 3

September 2019 - 58 articles

Cover Story: Diffusion MRI can measure brain structural connectivity using fibre-tracking; however, a number of practical considerations must be considered to increase the robustness of tracking results. This article describes what we consider the ‘seven deadly sins’ of mapping structural connections using diffusion MRI streamlines fibre-tracking. The recommendations here are intended to inform users on potential important shortcomings of their protocols, as well as to guide future users on key issues and decisions that must be faced when designing their processing pipelines. View this paper.
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Articles (58)

  • Article
  • Open Access
4 Citations
7,685 Views
10 Pages

Evaluation of Acridine Orange Staining for a Semi-Automated Urinalysis Microscopic Examination at the Point-of-Care

  • Amy J. Powless,
  • Sandra P. Prieto,
  • Madison R. Gramling,
  • Roxanna J. Conley,
  • Gregory G. Holley and
  • Timothy J. Muldoon

18 September 2019

A urinary tract infection (UTI) can be diagnosed via urinalysis, consisting of a dipstick test and manual microscopic examination. Point-of-care (POC) image-based systems have been designed to automate the microscopic examination for low-volume labor...

  • Article
  • Open Access
3 Citations
4,288 Views
8 Pages

Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

  • Melinda Barkhuizen,
  • Johan S.H. Vles,
  • Ralph van Mechelen,
  • Marijne Vermeer,
  • Boris W. Kramer,
  • Peter Chedraui,
  • Paul Bergs,
  • Vivianne H.J.M. van Kranen-Mastenbroek and
  • Antonio W.D. Gavilanes

18 September 2019

Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present res...

  • Review
  • Open Access
35 Citations
7,517 Views
16 Pages

Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives

  • Elena-Daniela Grigorescu,
  • Cristina-Mihaela Lacatusu,
  • Mariana Floria,
  • Bogdan-Mircea Mihai,
  • Ioana Cretu and
  • Laurentiu Sorodoc

17 September 2019

In-depth understanding of early cardiovascular manifestations in diabetes is high on international research and prevention agendas given that cardiovascular events are the leading cause of death for diabetic patients. Our aim was to review recent dev...

  • Review
  • Open Access
31 Citations
10,227 Views
26 Pages

Characteristics of in Vivo Model Systems for Ovarian Cancer Studies

  • Patrycja Tudrej,
  • Katarzyna Aleksandra Kujawa,
  • Alexander Jorge Cortez and
  • Katarzyna Marta Lisowska

14 September 2019

An understanding of the molecular pathogenesis and heterogeneity of ovarian cancer holds promise for the development of early detection strategies and novel, efficient therapies. In this review, we discuss the advantages and limitations of animal mod...

  • Article
  • Open Access
9 Citations
3,406 Views
11 Pages

Glutathione Blood Concentrations: A Biomarker of Oxidative Damage Protection during Cardiopulmonary Bypass in Children

  • Angela Satriano,
  • Simone Franchini,
  • Giuseppe Lapergola,
  • Francesca Pluchinotta,
  • Luigi Anastasia,
  • Ekaterina Baryshnikova,
  • Giovanni Livolti and
  • Diego Gazzolo

13 September 2019

Background. Pediatric open-heart surgery with cardiopulmonary bypass (CPB) still remains a risky interventional procedure at high mortality/morbidity. To date, there are no clinical, laboratory, and/or monitoring parameters providing useful informati...

  • Article
  • Open Access
23 Citations
4,173 Views
11 Pages

Strain Elastography as a Valuable Diagnosis Tool in Intermediate Cytology (Bethesda III) Thyroid Nodules

  • Dana Stoian,
  • Florin Borcan,
  • Izabella Petre,
  • Ioana Mozos,
  • Flore Varcus,
  • Viviana Ivan,
  • Andreea Cioca,
  • Adrian Apostol and
  • Cristina Adriana Dehelean

13 September 2019

Fine needle aspiration (FNA) is considered the gold standard in the diagnostic of thyroid nodules. Using the recommended BETHESDA reporting system, up to 20% of results are classified as intermediate cytology. As there is no consensus whether ultraso...

  • Article
  • Open Access
7 Citations
3,858 Views
14 Pages

Analytical Evaluation of an NGS Testing Method for Routine Molecular Diagnostics on Melanoma Formalin-Fixed, Paraffin-Embedded Tumor-Derived DNA

  • Irene Mancini,
  • Lisa Simi,
  • Francesca Salvianti,
  • Francesca Castiglione,
  • Gemma Sonnati and
  • Pamela Pinzani

12 September 2019

Next Generation Sequencing (NGS) is a promising tool for the improvement of tumor molecular profiling in view of the identification of a personalized treatment in oncologic patients. To verify the potentiality of a targeted NGS (Ion AmpliSeq™ C...

  • Review
  • Open Access
9 Citations
6,224 Views
11 Pages

This paper summarises the current status of two novel short cognitive tests (SCT), known as Test Your Memory (TYM) and Test Your Memory for Mild Cognitive Impairment (TYM-MCI). The history of and recent research on the TYM and TYM-MCI are summarised...

  • Review
  • Open Access
61 Citations
7,137 Views
13 Pages

Over the past 35 years, the proliferation of technology and the advent of the internet have resulted in many reliable and easy to administer batteries for assessing cognitive function. These approaches have great potential for affecting how the healt...

  • Review
  • Open Access
74 Citations
12,356 Views
17 Pages

There is great interest in the study of brain structural connectivity, as white matter abnormalities have been implicated in many disease states. Diffusion magnetic resonance imaging (MRI) provides a powerful means to characterise structural connecti...

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Diagnostics - ISSN 2075-4418