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Open AccessArticle

The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes

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Department of Practical Obstetrics, Medical University of Lodz, 90-419 Lodz, Poland
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Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-419 Lodz, Poland
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Department of Internal Medicine and Nephrodiabetology, Medical University of Lodz, 90-419 Lodz, Poland
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Department of Pediatrics, Silesian Medical University in Katowice, 40-055 Katowice, Poland
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Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, 90-419 Lodz, Poland
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Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, 90-419 Lodz, Poland
*
Author to whom correspondence should be addressed.
Diagnostics 2019, 9(3), 105; https://doi.org/10.3390/diagnostics9030105
Received: 30 July 2019 / Revised: 21 August 2019 / Accepted: 23 August 2019 / Published: 26 August 2019
(This article belongs to the Special Issue Diagnosis and Management of Pediatric Diseases)
The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1 diabetes (T1D) in comparison to the control group and in relation to markers of diabetes metabolic control. The study group consisted of 111 patients with an average of 6-years of T1D duration. The control group included 36 gender- and age-matched individuals. In all patients optical coherence tomography (OCT) study was performed using HD-OCT Cirrus 5000 with evaluation of optic nerve head (ONH) parameters, thickness of retinal nerve fiber layer (RNFL) with its quadrants, macular full-thickness parameters, ganglion cells with inner plexus layer (GCIPL) and choroidal thickness (CT). Lower disc area value was observed in the study group as compared to controls (p = 0.0215). Negative correlations were found both between age at examination and rim area (R = −0.28, p = 0.0007) and between superior RNFL thickness and duration of diabetes (R = −0.20, p = 0.0336). Positive correlation between center thickness and SD for average glycemia (R = 0.30, p = 0.0071) was noted. Temporal CT correlated positively with age at examination (R = 0.21, p = 0.0127). The selected parameters the HD-OCT study may in the future serve as potential markers of preclinical phase of DR in patients with T1D. View Full-Text
Keywords: diabetic retinopathy; type 1 diabetes; HD-OCT; ONH; RNFL; choroidal thickness diabetic retinopathy; type 1 diabetes; HD-OCT; ONH; RNFL; choroidal thickness
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Kołodziej, M.; Waszczykowska, A.; Korzeniewska-Dyl, I.; Pyziak-Skupien, A.; Walczak, K.; Moczulski, D.; Jurowski, P.; Młynarski, W.; Szadkowska, A.; Zmysłowska, A. The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes. Diagnostics 2019, 9, 105.

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