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Diagnostics
Volume 9
Issue 3
10.3390/diagnostics9030105
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Article

The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes

by 1,
Arleta Waszczykowska
2,
Irmina Korzeniewska-Dyl
3,
Aleksandra Pyziak-Skupien
4,
Konrad Walczak
3,
Dariusz Moczulski
3,
Piotr Jurowski
2, 5,
Agnieszka Szadkowska
6 and
Agnieszka Zmysłowska
6,*
1
Department of Practical Obstetrics, Medical University of Lodz, 90-419 Lodz, Poland
2
Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-419 Lodz, Poland
3
Department of Internal Medicine and Nephrodiabetology, Medical University of Lodz, 90-419 Lodz, Poland
4
Department of Pediatrics, Silesian Medical University in Katowice, 40-055 Katowice, Poland
5
Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, 90-419 Lodz, Poland
6
Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, 90-419 Lodz, Poland
*
Author to whom correspondence should be addressed.
Diagnostics 2019, 9(3), 105; https://doi.org/10.3390/diagnostics9030105
Received: 30 July 2019 / Revised: 21 August 2019 / Accepted: 23 August 2019 / Published: 26 August 2019
(This article belongs to the Special Issue Diagnosis and Management of Pediatric Diseases)
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Abstract

The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1 diabetes (T1D) in comparison to the control group and in relation to markers of diabetes metabolic control. The study group consisted of 111 patients with an average of 6-years of T1D duration. The control group included 36 gender- and age-matched individuals. In all patients optical coherence tomography (OCT) study was performed using HD-OCT Cirrus 5000 with evaluation of optic nerve head (ONH) parameters, thickness of retinal nerve fiber layer (RNFL) with its quadrants, macular full-thickness parameters, ganglion cells with inner plexus layer (GCIPL) and choroidal thickness (CT). Lower disc area value was observed in the study group as compared to controls (p = 0.0215). Negative correlations were found both between age at examination and rim area (R = −0.28, p = 0.0007) and between superior RNFL thickness and duration of diabetes (R = −0.20, p = 0.0336). Positive correlation between center thickness and SD for average glycemia (R = 0.30, p = 0.0071) was noted. Temporal CT correlated positively with age at examination (R = 0.21, p = 0.0127). The selected parameters the HD-OCT study may in the future serve as potential markers of preclinical phase of DR in patients with T1D. View Full-Text
Keywords: diabetic retinopathy; type 1 diabetes; HD-OCT; ONH; RNFL; choroidal thickness diabetic retinopathy; type 1 diabetes; HD-OCT; ONH; RNFL; choroidal thickness
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MDPI and ACS Style

Kołodziej, M.; Waszczykowska, A.; Korzeniewska-Dyl, I.; Pyziak-Skupien, A.; Walczak, K.; Moczulski, D.; Jurowski, P.; Młynarski, W.; Szadkowska, A.; Zmysłowska, A. The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes. Diagnostics 2019, 9, 105. https://doi.org/10.3390/diagnostics9030105

AMA Style

Kołodziej M, Waszczykowska A, Korzeniewska-Dyl I, Pyziak-Skupien A, Walczak K, Moczulski D, Jurowski P, Młynarski W, Szadkowska A, Zmysłowska A. The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes. Diagnostics. 2019; 9(3):105. https://doi.org/10.3390/diagnostics9030105

Chicago/Turabian Style

Kołodziej, Magdalena, Arleta Waszczykowska, Irmina Korzeniewska-Dyl, Aleksandra Pyziak-Skupien, Konrad Walczak, Dariusz Moczulski, Piotr Jurowski, Wojciech Młynarski, Agnieszka Szadkowska, and Agnieszka Zmysłowska. 2019. "The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes" Diagnostics 9, no. 3: 105. https://doi.org/10.3390/diagnostics9030105

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