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Open AccessArticle

Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

1
Department of Pediatrics, Maastricht University Medical Centre (MUMC), 6229HX, Maastricht, The Netherlands
2
Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands
3
DST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom 2531, South Africa
4
Child Neurology, Maastricht University Medical Centre, 6229 HX, Maastricht, The Netherlands
5
Instituto de Investigación e Innovación de Salud Integral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil 090615, Ecuador
6
Clinical Neurophysiology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Diagnostics 2019, 9(3), 123; https://doi.org/10.3390/diagnostics9030123
Received: 16 August 2019 / Revised: 3 September 2019 / Accepted: 12 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Diagnosis and Management of Pediatric Diseases)
Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats. View Full-Text
Keywords: somatosensory evoked potential; preterm brain; rat model; cerebral palsy; hypoxia-ischemia somatosensory evoked potential; preterm brain; rat model; cerebral palsy; hypoxia-ischemia
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MDPI and ACS Style

Barkhuizen, M.; Vles, J.S.; van Mechelen, R.; Vermeer, M.; Kramer, B.W.; Chedraui, P.; Bergs, P.; van Kranen-Mastenbroek, V.H.; Gavilanes, A.W. Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats. Diagnostics 2019, 9, 123.

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