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Open AccessArticle

Design and Benchmark Testing for Open Architecture Reconfigurable Mobile Spirometer and Exhaled Breath Monitor with GPS and Data Telemetry

1
Department of Mechanical and Aerospace Engineering, University of California, Davis, CA 95616, USA
2
Department of Internal Medicine, 4150 V Street, Suite 3400, University of California, Davis, Sacramento, CA 95817, USA
3
VA Northern California Health Care System, 10535 Hospital Way, Mather, CA 95655, USA
4
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Present address: Division of Pulmonary, Critical Care, Hyperbaric Oxygen, Allergy and Sleep Medicine, Department of Internal Medicine, School of Medicine Loma Linda University, Loma Linda, CA 92354, USA.
§
Present address: University of California, San Francisco, Fresno, CA 93701, USA.
Diagnostics 2019, 9(3), 100; https://doi.org/10.3390/diagnostics9030100
Received: 26 July 2019 / Revised: 9 August 2019 / Accepted: 20 August 2019 / Published: 21 August 2019
(This article belongs to the Section Point-of-Care Diagnostics and Devices)
Portable and wearable medical instruments are poised to play an increasingly important role in health monitoring. Mobile spirometers are available commercially, and are used to monitor patients with advanced lung disease. However, these commercial monitors have a fixed product architecture determined by the manufacturer, and researchers cannot easily experiment with new configurations or add additional novel sensors over time. Spirometry combined with exhaled breath metabolite monitoring has the potential to transform healthcare and improve clinical management strategies. This research provides an updated design and benchmark testing for a flexible, portable, open access architecture to measure lung function, using common Arduino/Android microcontroller technologies. To demonstrate the feasibility and the proof-of-concept of this easily-adaptable platform technology, we had 43 subjects (healthy, and those with lung diseases) perform three spirometry maneuvers using our reconfigurable device and an office-based commercial spirometer. We found that our system compared favorably with the traditional spirometer, with high accuracy and agreement for forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), and gas measurements were feasible. This provides an adaptable/reconfigurable open access “personalized medicine” platform for researchers and patients, and new chemical sensors and other modular instrumentation can extend the flexibility of the device in the future. View Full-Text
Keywords: breath analysis; spirometry; personalized medicine; telehealth breath analysis; spirometry; personalized medicine; telehealth
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Fung, A.G.; Tan, L.D.; Duong, T.N.; Schivo, M.; Littlefield, L.; Delplanque, J.P.; Davis, C.E.; Kenyon, N.J. Design and Benchmark Testing for Open Architecture Reconfigurable Mobile Spirometer and Exhaled Breath Monitor with GPS and Data Telemetry. Diagnostics 2019, 9, 100.

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