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Diagnostics, Volume 15, Issue 9

May-1 2025 - 131 articles

Cover Story: Helicobacter pylori is a major risk factor for gastric cancer. The incidence and prevalence of the pathogen are increasing worldwide. We present an algorithm combining a feature pyramid network and a ResNet architecture for automatic and rapid H. pylori detection in digitized Warthin–Starry-stained gastric biopsies. The algorithm exhibited 0.923 average precision and 0.982 average recall. The conducted efficiency study demonstrated that algorithm utilization significantly decreased (p < 0.001) diagnostic turnaround times for all participants, observing an 88.13–91.76% time reduction. Implementation of the algorithm also improved diagnostic accuracy for the resident, technician, and biotechnologist, indicating that the tool remarkably supports less experienced personnel. View this paper
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Articles (131)

  • Article
  • Open Access
2,784 Views
14 Pages

Mucoepidermoid Carcinoma of the Minor Salivary Glands Diagnosed by High-Definition Ultrasound and Fine-Needle Aspiration: A Milan System-Based Retrospective Study

  • Luisa Limongelli,
  • Marta Forte,
  • Gianfranco Favia,
  • Fabio Dell’Olio,
  • Giuseppe Ingravallo,
  • Eliano Cascardi,
  • Eugenio Maiorano,
  • Alfonso Manfuso,
  • Chiara Copelli and
  • Antonio d’Amati
  • + 1 author

Background/Objectives: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the minor salivary glands, often affecting the hard palate. Preoperative diagnosis and surgical planning are challenging due to anatomical complexity and limi...

  • Systematic Review
  • Open Access
2,332 Views
17 Pages

A Closer Look at Periocular Necrotizing Fasciitis: A Systematic Review of Literature

  • David Oliver-Gutierrez,
  • Elena Ros-Sanchez,
  • Gloria Segura-Duch,
  • Tirso Alonso,
  • Miguel Ángel Arcediano,
  • Alejandra Herranz-Cabarcos,
  • Jessica Matas,
  • Roberto Castro Seco,
  • R. L. P. van der Veen and
  • Anna Boixadera
  • + 2 authors

Background: Periocular necrotizing fasciitis (PNF) is a rare but life-threatening emergency that requires immediate recognition, as delayed diagnosis can worsen patient outcomes. To address this critical issue, we conducted the largest and most compr...

  • Review
  • Open Access
4 Citations
4,067 Views
21 Pages

Ultrasonography of the Fasciae and Common Pathologies: The Game Changer

  • Carmelo Pirri,
  • Nina Pirri,
  • Veronica Macchi,
  • Andrea Porzionato,
  • Raffaele De Caro,
  • Levent Özçakar and
  • Carla Stecco

Ultrasound (US) is rapidly gaining attraction among physicians for the evaluation of fasciae. Unlike traditional imaging, which often lacks specificity of pain localization, US examination stands out as a versatile tool, capable of detecting both str...

  • Case Report
  • Open Access
2 Citations
2,853 Views
17 Pages

Calciphylaxis of the Upper Limbs—A Rare and Serious Disease with Multidisciplinary Treatments—A Case Series and Literature Review

  • Mihaela Pertea,
  • Malek Benamor,
  • Andra-Irina Bulgaru-Iliescu,
  • Abderrazek Abid,
  • Said Abid and
  • Alexandru-Hristo Amarandei

Background/Objectives: Calciphylaxis or calcific uremic arteriolopathy is a rare but highly lethal pathology that occurs most frequently in a uremic context, although it can also occur outside of this context. It is characterized by the appearance of...

  • Review
  • Open Access
4 Citations
3,669 Views
18 Pages

Neurodegenerative Biomarkers in Multiple Sclerosis: At the Interface Between Research and Clinical Practice

  • Alin Ciubotaru,
  • Mădălina Irina Smihor,
  • Cristina Grosu,
  • Daniel Alexa,
  • Roxana Covali,
  • Robert-Constantin Anicăi,
  • Ioana Păvăleanu,
  • Andrei Ionuț Cucu,
  • Amelian Mădălin Bobu and
  • Cristina Mihaela Ghiciuc
  • + 1 author

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While the inflammatory components of MS have been extensively studied, the progressi...

  • Systematic Review
  • Open Access
1 Citations
2,272 Views
18 Pages

Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Akash Kumar,
  • Muhammad Salman Nadeem,
  • Sooraj Kumar,
  • Muzamil Akhtar,
  • Ayesha Maryam,
  • Rubyisha Sheikh,
  • Nomesh Kumar,
  • Naresh Kumar Ladhwani,
  • Nimurta Madhwani and
  • Nisha Kumari
  • + 4 authors

Background/Objectives: Despite the potential benefits, intravascular imaging for guiding percutaneous coronary intervention (PCI) remains underutilized. Recent trials have provided new data, prompting a need for updated insights. This study aimed to...

  • Article
  • Open Access
2 Citations
2,581 Views
34 Pages

Background/Objectives: Liver cirrhosis is a critical chronic condition with increasing global mortality and morbidity rates, emphasizing the necessity for early and accurate diagnosis. This study proposes a comprehensive deep-learning framework for t...

  • Review
  • Open Access
4 Citations
6,045 Views
26 Pages

Advancing Cervical Cancer Prevention Equity: Innovations in Self-Sampling and Digital Health Technologies Across Healthcare Settings

  • Michelle Gomes,
  • Elena Provaggi,
  • Andrea Barnabas Pembe,
  • Adeola Olaitan and
  • Aleksandra Gentry-Maharaj

Cervical cancer causes 350,000 deaths annually, with 90% occurring in low- and middle-income countries (LMICs), despite being largely preventable through vaccination and screening. This review examines innovative approaches to address screening cover...

  • Review
  • Open Access
1,645 Views
12 Pages

Cervical cancer remains a significant health challenge globally, with locally advanced cervical cancer (LACC) representing a particularly complex subset due to its diverse definitions and varied treatment approaches. The absence of randomized control...

  • Protocol
  • Open Access
1 Citations
2,031 Views
13 Pages

Real-World, National Study of Palbociclib in HR+/HER2− Metastatic Breast Cancer: A 2.5-Year Follow-Up PALBO01/2021

  • Cristina Marinela Oprean,
  • Larisa Maria Badau,
  • Ramona Petrita,
  • Mircea Dragos Median and
  • Alis Dema

Background: Palbociclib, when combined with endocrine therapy, represents a valuable treatment option for patients diagnosed with hormone receptor (HR) positive/human epidermal growth factor receptor 2 (HER2) negative advanced breast cancer (BC) or m...

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Diagnostics - ISSN 2075-4418