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Diagnostics
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Advances in the Diagnosis of Eye Diseases
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Advances in the Diagnosis of Eye Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 5276

Special Issue Editor

Dr. Ivan Tanev

E-Mail Website
Guest Editor
Eye Clinic Zrenieto, 1000 Sofia, Bulgaria
Interests: ophthalmology; glaucoma; age-related macular degeneration

Special Issue Information

Dear Colleagues,

Eye diseases, such as cataracts, glaucoma, age-related macular degeneration, and diabetic retinopathy, continue to represent leading causes of vision impairment and blindness worldwide. Timely and accurate diagnosis is crucial in providing appropriate treatment and preventing irreversible vision loss. Hence, this Special Issue will highlight cutting-edge research, innovative technologies, and novel approaches that are improving the early detection, diagnosis, and monitoring of eye diseases.

We invite researchers to submit original research findings, review articles, and case studies that demonstrate advancements in diagnostic tools, imaging techniques, biomarkers, artificial intelligence applications, and other innovative approaches to the diagnosis of eye diseases.

Overall, the goal of this Special Issue is to provide a platform for sharing and disseminating the latest developments in the diagnosis of eye diseases, ultimately leading to improved patient outcomes and better management of eye health. We hope that this Special Issue will inspire further research and innovation in this critical area of ophthalmology.

Dr. Ivan Tanev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cataracts
  • glaucoma
  • age-related macular degeneration
  • diabetic retinopathy
  • OCT
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

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Research

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11 pages, 2214 KiB  
Article
Influence of Aflibercept on Choroidal Blood Flow and Thickness in Branch Retinal Vein Occlusion: A Six-Month Follow-Up Study
by Ryuya Hashimoto, Kenichiro Aso, Keisuke Yata, Kazufumi Tanaka, Naoki Fujioka, Ryo Yamazaki, Serika Moriyama, Juri Kawamura, Asato Hirota and Takatoshi Maeno
Diagnostics 2024, 14(22), 2484; https://doi.org/10.3390/diagnostics14222484 - 7 Nov 2024
Viewed by 882
Abstract
Background/Objectives: We intended to investigate choroidal blood flow (CBF) and choroidal thickness (CT) alternations in treatment-naive eyes with non-ischemic branch retinal vein occlusion (BRVO) following intravitreal aflibercept injection (IVA). Methods: Twenty eyes of 20 patients with treatment-naive non-ischemic BRVO, treated with IVA 1+ [...] Read more.
Background/Objectives: We intended to investigate choroidal blood flow (CBF) and choroidal thickness (CT) alternations in treatment-naive eyes with non-ischemic branch retinal vein occlusion (BRVO) following intravitreal aflibercept injection (IVA). Methods: Twenty eyes of 20 patients with treatment-naive non-ischemic BRVO, treated with IVA 1+ pro re nata, were included in this study. In the BRVO eyes, CBF and CT were measured in the occlusive region, subfovea, as well as the non-occlusive region, via laser speckle flowgraphy (LSFG) and enhanced depth-imaging optical coherence tomography over a 6-month follow-up period. CBF was analyzed via the mean blur rate using LSFG analysis software (version 3.10.0). Results: CT showed significant reductions in both the occlusive and subfoveal region at 1 week and 1 month after treatment (both p < 0.05). CBF was significantly decreased in the subfovea and the non-occlusive region at 1 week and 1 month from baseline, respectively (both p < 0.05). The mean number of IVA injections during the 6-month period was 1.95 ± 0.6. Conclusions: Aflibercept treatment reduced CBF and CT in addition to a decrease in retinal thickness. These changes at each region might be associated with the improvement of macular edema in BRVO eyes. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Eye Diseases)
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8 pages, 229 KiB  
Article
Evaluating Diagnostic Concordance in Primary Open-Angle Glaucoma Among Academic Glaucoma Subspecialists
by Chenmin Wang, De-Fu Chen, Xiao Shang, Xiaoyan Wang, Xizhong Chu, Chengju Hu, Qiangjie Huang, Gangwei Cheng, Jianjun Li, Ruiyi Ren and Yuanbo Liang
Diagnostics 2024, 14(21), 2460; https://doi.org/10.3390/diagnostics14212460 - 3 Nov 2024
Cited by 1 | Viewed by 1347
Abstract
Objective: The study aimed to evaluate the interobserver agreement among glaucoma subspecialists in diagnosing glaucoma and to explore the causes of diagnostic discrepancies. Methods: Three experienced glaucoma subspecialists independently assessed frequency domain optical coherence tomography, fundus color photographs, and static perimetry results from [...] Read more.
Objective: The study aimed to evaluate the interobserver agreement among glaucoma subspecialists in diagnosing glaucoma and to explore the causes of diagnostic discrepancies. Methods: Three experienced glaucoma subspecialists independently assessed frequency domain optical coherence tomography, fundus color photographs, and static perimetry results from 464 eyes of 275 participants, adhering to unified glaucoma diagnostic criteria. All data were collected from the Wenzhou Glaucoma Progression Study between August 2014 and June 2021. Results: The overall interobserver agreement among the three experts was poor, with a Fleiss’ kappa value of 0.149. The kappa values interobserver agreement between pairs of experts ranged from 0.133 to 0.282. In 50 cases, or approximately 10.8%, the three experts reached completely different diagnoses. Agreement was more likely in cases involving larger average cup-to-disc ratios, greater vertical cup-to-disc ratios, more severe visual field defects, and thicker retinal nerve fiber layer measurements, particularly in the temporal and inferior quadrants. High myopia also negatively impacted interobserver agreement. Conclusions: Despite using unified diagnostic criteria for glaucoma, significant differences in interobserver consistency persist among glaucoma subspecialists. To improve interobserver agreement, it is recommended to provide additional training on standardized diagnostic criteria. Furthermore, for cases with inconsistent diagnoses, long-term follow-up is essential to confirm the diagnosis of glaucoma. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Eye Diseases)
14 pages, 6871 KiB  
Article
Baseline Choroidal Blood Flow Imbalance as a Predictive Factor for Macular Edema Recurrence Secondary to Branch Retinal Vein Occlusion
by Ryuya Hashimoto, Kenichiro Aso, Keisuke Yata, Naoki Fujioka, Kazufumi Tanaka, Serika Moriyama, Asato Hirota, Juri Kawamura and Takatoshi Maeno
Diagnostics 2024, 14(20), 2328; https://doi.org/10.3390/diagnostics14202328 - 18 Oct 2024
Cited by 2 | Viewed by 1069
Abstract
Background/Objectives: To evaluate the roles of choroidal blood flow (CBF) and choroidal thickness (CT) as predictors of macular edema recurrence in patients with treatment-naive non-ischemic branch retinal vein occlusion (BRVO) after intravitreal ranibizumab (IVR) injection. Methods: Sixteen eyes from sixteen patients with treatment-naive [...] Read more.
Background/Objectives: To evaluate the roles of choroidal blood flow (CBF) and choroidal thickness (CT) as predictors of macular edema recurrence in patients with treatment-naive non-ischemic branch retinal vein occlusion (BRVO) after intravitreal ranibizumab (IVR) injection. Methods: Sixteen eyes from sixteen patients with treatment-naive non-ischemic BRVO treated with IVR, once initially and then as needed, were included in the study. CBF and CT in the subfovea, occlusive, and non-occlusive regions were measured via laser speckle flowgraphy and enhanced depth imaging optical coherence tomography over 12 months. Results: Baseline CT was significantly greater in the occlusive region (335 ± 72.1 µm) than in the non-occlusive region (274 ± 36.7 µm, p = 0.028). CT in the occlusive region was reduced significantly after 1 week (p = 0.008), but CBF did not change significantly after IVR throughout the follow-up period (p > 0.05). The occlusive/non-occlusive region CBF ratio at baseline was significantly associated with the number of IVR injections over 12 months (mean 2.63) in patients with BRVO (p = 0.048). Conclusions: Baseline CBF imbalance in eyes with treatment-naive BRVO may indicate the recurrence of macular edema after ranibizumab therapy. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Eye Diseases)
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17 pages, 886 KiB  
Systematic Review
A Closer Look at Periocular Necrotizing Fasciitis: A Systematic Review of Literature
by David Oliver-Gutierrez, Elena Ros-Sanchez, Gloria Segura-Duch, Tirso Alonso, Miguel Ángel Arcediano, Alejandra Herranz-Cabarcos, Jessica Matas, Roberto Castro Seco, R. L. P. van der Veen, Anna Boixadera, José García-Arumí and Joan Oliveres
Diagnostics 2025, 15(9), 1181; https://doi.org/10.3390/diagnostics15091181 - 7 May 2025
Viewed by 339
Abstract
Background: Periocular necrotizing fasciitis (PNF) is a rare but life-threatening emergency that requires immediate recognition, as delayed diagnosis can worsen patient outcomes. To address this critical issue, we conducted the largest and most comprehensive systematic review to date, providing valuable insights into [...] Read more.
Background: Periocular necrotizing fasciitis (PNF) is a rare but life-threatening emergency that requires immediate recognition, as delayed diagnosis can worsen patient outcomes. To address this critical issue, we conducted the largest and most comprehensive systematic review to date, providing valuable insights into the diagnosis and treatment of PNF to improve clinical practice and patient prognosis. Methods: A search on Pubmed, Scopus, Embase, and WOS from January 2013 to August 2024 was performed. Only the cases of NF affecting the periocular region were included with no age limitations. Article selection and data extraction were performed independently by two investigators to avoid bias. Bias on individual studies is low as they represent case reports or case series, and publication bias is partially addressed including all the large case series even if no individual data could be retrieved. Results: The cohort included a total of 183 patients with PNF, with detailed patient-specific data for 107 individuals and only aggregated data for another 76. The average age at diagnosis was 54.2 years, and females constituted 44% of the population sample. Notably, 49.6% of the patients were immunocompromised. Streptococcus pyogenes was the predominant causative organism, identified in 79.8% of the cases. Most infections were unilateral (72.1%) without extension beyond the periocular area (54.7%). Most patients (89.6%) underwent surgical debridement alongside intravenous antibiotics. Septic shock occurred in 26.8% of the patients, and the overall mortality rate was 4.9%. Visual acuity was unaffected in 67.5% of the patients, though 18.2% progressed to blindness on the affected side. Reconstructive efforts predominantly involved skin grafting, both free and local pedunculate flaps as well as secondary healing in some instances. Conclusions: This systematic review summarizes the understanding of periocular necrotizing fasciitis’ (PNF) demographic trends, clinical manifestations, causative pathogens, and patient outcomes. Vigilance for PNF should be heightened when the clinical assessment of the patient’s eyelids reveals rapidly spreading edema and induration, subcutaneous emphysema, or necrotic bullae and/or eschar. Prompt identification and expedited intervention, including debridement and targeted antibiotic therapy, critically influence prognosis. Despite optimal management, patients may still suffer from significant aesthetic impairment, severe complications such as vision loss, or death due to septic shock. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Eye Diseases)
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3 pages, 3704 KiB  
Interesting Images
Unilateral Exudative Retinal Detachment and Uveitis Accompanied by a Large Subretinal Deposit on the Macula Secondary to Bartonella Henselae Infection
by Tianwei Liang, Yanhui Cui, Man Hu, Di Cao, Honggai Yan and Li Li
Diagnostics 2024, 14(23), 2767; https://doi.org/10.3390/diagnostics14232767 - 9 Dec 2024
Viewed by 905
Abstract
Bartonella henselae is a Gram-negative bacillus, mainly parasitizing on cats. When a child is scratched by a cat, they may present with the disease symptoms including regional lymphadenopathy, malaise, fever, and splenomegaly, which is known as cat-scratch disease (CSD). Ocular manifestations occur in [...] Read more.
Bartonella henselae is a Gram-negative bacillus, mainly parasitizing on cats. When a child is scratched by a cat, they may present with the disease symptoms including regional lymphadenopathy, malaise, fever, and splenomegaly, which is known as cat-scratch disease (CSD). Ocular manifestations occur in 5–10% of patients with CSD. Neuroretinitis is the most common, and, in addition, Parinaud oculoglandular syndrome, endophthalmitis, retinochoroiditis, vascular occlusions, multiple mass-like lesions resembling ocular metastases, serous macular detachments, and retinal vasoproliferative lesions may also occur. We report a case of unilateral exudative retinal detachment and uveitis with a large subretinal deposit on the macula in a 6-year-old female with CSD, along with lymphadenitis on her left thigh. To the best of our knowledge, this case of exudative retinal detachment and uveitis with a large subretinal deposit under the retina affecting the macular area above the optic disc has not been previously reported. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Eye Diseases)
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