Diagnosis and Management of Coronary Heart Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 608

Special Issue Editor


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Guest Editor
Institute of Cardiovascular Science, University College London, London, UK
Interests: cardiology; cardiovascular diseases

Special Issue Information

Dear Colleagues,

Coronary artery disease (CAD) remains a significant health challenge, placing a heavy burden on people and healthcare systems globally. CAD, caused by the formation of plaque in blood vessels and resulting in a demand–supply mismatch of oxygen, can lead to severe complications such as heart attacks and heart failure. Collaborative efforts by researchers, professionals, and governments have led to progress in understanding and managing this cardiovascular condition. New strategies for treating CAD now include modern diagnostics, pharmaceuticals, invasive procedures, lifestyle changes, and cardiac rehabilitation.

Improvements in the diagnosis and management of coronary heart disease (CHD) have greatly enhanced patient outcomes due to advancements in medical technology. Early detection has been transformed by non-invasive imaging techniques such as coronary CT angiography, which provides detailed views of coronary arteries, and adding CT-Fractional Flow Reserve (CT-FFR) technology, which enables faster and more accurate diagnoses. Biomarkers, such as high-sensitivity troponin tests, have further improved the precision of the detection of acute coronary syndromes, enabling early intervention.

In the management of CAD, intravascular imaging technologies, such as intravascular ultrasound (IVUS) and optical coherence tomography (OCT), have significantly improved the outcomes of percutaneous coronary interventions (PCIs), including plaque preparation, stent size, and stent failure.

Pharmacological developments, including modern cholesterol-lowering drugs, have been crucial for achieving cholesterol target levels, as per the recent guidelines.

By staying updated about the latest advancements in the diagnosis and management of coronary artery disease and adopting a patient-centred approach, researchers can reduce the impact of CAD and improve the life chances of the patients affected by this disease.

Dr. Luciano Candilio
Guest Editor

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Keywords

  • coronary heart disease
  • coronary revascularization
  • coronary artery disease
  • ischemic heart disease
  • atherosclerosis
  • cardiovascular disease
  • non-invasive coronary diagnostic tests

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Published Papers (1 paper)

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18 pages, 3032 KiB  
Systematic Review
Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Akash Kumar, Muhammad Salman Nadeem, Sooraj Kumar, Muzamil Akhtar, Ayesha Maryam, Rubyisha Sheikh, Nomesh Kumar, Naresh Kumar Ladhwani, Nimurta Madhwani, Nisha Kumari, Muhammad Riyyan Rao, Syed Sarmad Javaid, Peter Collins and Raheel Ahmed
Diagnostics 2025, 15(9), 1175; https://doi.org/10.3390/diagnostics15091175 - 6 May 2025
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Abstract
Background/Objectives: Despite the potential benefits, intravascular imaging for guiding percutaneous coronary intervention (PCI) remains underutilized. Recent trials have provided new data, prompting a need for updated insights. This study aimed to perform a comprehensive meta-analysis to compare the clinical outcomes of intravascular imaging-guided [...] Read more.
Background/Objectives: Despite the potential benefits, intravascular imaging for guiding percutaneous coronary intervention (PCI) remains underutilized. Recent trials have provided new data, prompting a need for updated insights. This study aimed to perform a comprehensive meta-analysis to compare the clinical outcomes of intravascular imaging-guided PCI versus angiography-guided PCI, thereby evaluating the relative effectiveness of these two guidance strategies in improving patient outcomes. Methods: PubMed, Cochrane Library, Embase and Clinicaltrials.gov databases were systematically searched from inception till 25 November 2024. Randomized clinical trials (RCTs) comparing intravascular imaging with coronary angiography in patients undergoing complex PCI were included. Statistical analysis was conducted using a random effects model to calculate pooled risk ratios with 95% confidence intervals (CI). Results: In this meta-analysis of 21 studies involving 18,043 patients, intravascular image-guided PCI significantly reduced the risk of all-cause mortality by 24%, cardiac mortality by 63%, MACE by 35%, target vessel myocardial infarction by 32%, stent thrombosis by 42%, target vessel revascularization by 45%, target lesion revascularization by 34% and myocardial infarction by 22% compared to angiography-guided PCI. There was no significant difference in bleeding events. Conclusions: Intravascular imaging significantly reduces cardiac events, all-cause mortality and revascularization rates in PCI patients. These findings support its broader adoption and potential updates to clinical guidelines. Full article
(This article belongs to the Special Issue Diagnosis and Management of Coronary Heart Disease)
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