Diagnostics, Volume 14, Issue 23
2024 December-1 - 160 articles
Cover Story: Background: The study examines Diffusion Tensor Imaging’s (DTI's) role in predicting neoadjuvant chemo-response in locally advanced breast cancer. Methods: A DTI-MRI sequence, evaluating water diffusion along tissue structures, was performed before and after two chemo cycles. Results: We found a significant correlation between changes in specific DTI parameters (e.g., λ2, FA, RA) and pathological response, suggesting DTI as a sensitive marker for early chemo-response. Notably, 12-direction DTI may have better diagnostic accuracy than 6-direction DTI. The percentage change in FA demonstrated a strong ability to predict pathological complete response (pCR) with high sensitivity. Conclusions: DTI may assess chemotherapy efficacy as a non-invasive tool, but larger studies with standardized protocols are needed to confirm its clinical utility. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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