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Life, Volume 11, Issue 1

January 2021 - 72 articles

Cover Story: The endoplasmic reticulum is the protein synthesis factory of the cells. ER stress and unfolded protein response (UPR) are key cellular responses against misfolded protein accumulation in the ER. UPR maintains cellular balance and potentially is involved in pathogenesis of many diseases, including idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary (COPD) disease. Both genetic and environmental factors might be involved in UPR-induced IPF and COPD. UPR triggers programmed cell death (apoptosis), epithelial-to-mesenchymal transition (EMT), fibrosis and inflammation and potentially initiates IPF and COPD. Targeting different arms of UPR could be a future therapeutic approach for developing new therapies for IPF and COPD and bring hope to these patients for better quality of life. View this paper.
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Articles (72)

  • Review
  • Open Access
6 Citations
2,506 Views
16 Pages

Polymorphisms of ATP-Binding Cassette, Sub-Family A, Member 4 (rs560426 and rs481931) and Non-Syndromic Cleft Lip/Palate: A Meta-Analysis

  • Mohammad Moslem Imani,
  • Masoud Sadeghi,
  • Santosh Kumar Tadakamadla,
  • Annette Brühl,
  • Dena Sadeghi Bahmani,
  • Mohammad Taheri and
  • Serge Brand

15 January 2021

Background: A number of genes are associated with the incidence of non-syndromic cleft lip/palate (NSCL/P). Studies have shown a significant association between polymorphisms of ATP-binding cassette, sub-family A, member 4 (ABCA4) with the risk of NS...

  • Article
  • Open Access
3 Citations
2,856 Views
19 Pages

Insights into the Geomicrobiology of Biovermiculations from Rock Billet Incubation Experiments

  • Hilary Kelly,
  • Michael N. Spilde,
  • Daniel S. Jones and
  • Penelope J. Boston

15 January 2021

Biovermiculations are uniquely patterned organic rich sediment formations found on the walls of caves and other subterranean environments. These distinctive worm-like features are the combined result of physical and biological processes. The diverse...

  • Review
  • Open Access
128 Citations
13,408 Views
42 Pages

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

  • Carmine Izzo,
  • Paolo Vitillo,
  • Paola Di Pietro,
  • Valeria Visco,
  • Andrea Strianese,
  • Nicola Virtuoso,
  • Michele Ciccarelli,
  • Gennaro Galasso,
  • Albino Carrizzo and
  • Carmine Vecchione

15 January 2021

Aging can be seen as process characterized by accumulation of oxidative stress induced damage. Oxidative stress derives from different endogenous and exogenous processes, all of which ultimately lead to progressive loss in tissue and organ structure...

  • Review
  • Open Access
24 Citations
6,044 Views
10 Pages

15 January 2021

The incidence and severity of metabolic diseases can be reduced by introducing healthy lifestyle habits including moderate exercise. A common observation in age-related metabolic diseases is an increment in systemic inflammation (the so-called inflam...

  • Review
  • Open Access
12 Citations
6,120 Views
34 Pages

15 January 2021

Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal su...

  • Review
  • Open Access
19 Citations
6,885 Views
13 Pages

Hibernation as a Tool for Radiation Protection in Space Exploration

  • Anggraeini Puspitasari,
  • Matteo Cerri,
  • Akihisa Takahashi,
  • Yukari Yoshida,
  • Kenji Hanamura and
  • Walter Tinganelli

14 January 2021

With new and advanced technology, human exploration has reached outside of the Earth’s boundaries. There are plans for reaching Mars and the satellites of Jupiter and Saturn, and even to build a permanent base on the Moon. However, human beings...

  • Article
  • Open Access
10 Citations
3,418 Views
11 Pages

The Core of Gut Life: Firmicutes Profile in Patients with Relapsing-Remitting Multiple Sclerosis

  • Madina Kozhieva,
  • Natalia Naumova,
  • Tatiana Alikina,
  • Alexey Boyko,
  • Valentin Vlassov and
  • Marsel R. Kabilov

14 January 2021

The multiple sclerosis (MS) incidence rate has been increasing in Russia, but the information about the gut bacteriobiome in the MS-afflicted patients is scarce. Using the Illumina MiSeq sequencing of 16S rRNA gene amplicons, we aimed to analyze the...

  • Review
  • Open Access
42 Citations
8,753 Views
12 Pages

Long Non-Coding RNAs and Their Potential Roles in the Vector–Host–Pathogen Triad

  • Parwez Ahmad,
  • Chaima Bensaoud,
  • Imen Mekki,
  • Mujeeb Ur Rehman and
  • Michail Kotsyfakis

14 January 2021

Long non-coding (lnc)RNAs have emerged as critical regulators of gene expression and are involved in almost every cellular process. They can bind to other molecules including DNA, proteins, or even other RNA types such messenger RNA or small RNAs. Ln...

  • Article
  • Open Access
19 Citations
4,232 Views
17 Pages

14 January 2021

Growing evidence indicates that dysregulated iron metabolism with altered and excess iron availability in some body compartments plays a significant role in the course of infection and sepsis in humans. Given that all bacterial pathogens require iron...

  • Review
  • Open Access
34 Citations
7,125 Views
16 Pages

Clinical Implications of Uric Acid in Heart Failure: A Comprehensive Review

  • Marko Kumrić,
  • Josip A Borovac,
  • Tina Tičinović Kurir and
  • Joško Božić

14 January 2021

Affecting more than 26 million people worldwide and with rising prevalence, heart failure (HF) represents a major global health problem. Hence, further research is needed in order to abate poor HF outcomes and mitigate significant expenses that burde...

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Life - ISSN 2075-1729