Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination
Neuroscience Initiative Advanced Science Research Center, CUNY, 85 St Nicholas Terrace, New York, NY 10031, USA
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Life 2021, 11(1), 62; https://doi.org/10.3390/life11010062
Received: 19 December 2020
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Revised: 8 January 2021
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Accepted: 10 January 2021
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Published: 15 January 2021
(This article belongs to the Special Issue Myelin and Oligodendrocyte-Neuron Interactions)
Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal support and metabolism. Thus, a tight regulation of oligodendroglial cell specification, proliferation, and myelination is required for correct neuronal connectivity and function. Here, we review the role of epigenetic modifications in oligodendroglial lineage cells. First, we briefly describe the epigenetic modalities of gene regulation, which are known to have a role in oligodendroglial cells. We then address how epigenetic enzymes and/or marks have been associated with oligodendrocyte progenitor specification, survival and proliferation, differentiation, and finally, myelination. We finally mention how environmental cues, in particular, neuronal signals, are translated into epigenetic modifications, which can directly influence oligodendroglial biology.
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Keywords:
oligodendrocyte; oligodendrocyte progenitor cell; epigenetics; DNA methylation; histone; chromatin; long non-coding RNA; lamina
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MDPI and ACS Style
Pruvost, M.; Moyon, S. Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination. Life 2021, 11, 62. https://doi.org/10.3390/life11010062
AMA Style
Pruvost M, Moyon S. Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination. Life. 2021; 11(1):62. https://doi.org/10.3390/life11010062
Chicago/Turabian StylePruvost, Mathilde, and Sarah Moyon. 2021. "Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination" Life 11, no. 1: 62. https://doi.org/10.3390/life11010062
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