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Polymorphisms of ATP-Binding Cassette, Sub-Family A, Member 4 (rs560426 and rs481931) and Non-Syndromic Cleft Lip/Palate: A Meta-Analysis

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Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran
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Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran
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Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
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Senior Research and National Health and Medical Research Council Fellow, School of Dentistry and Oral Health, Griffith University, Gold Coast 4214, Australia
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Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, 4002 Basel, Switzerland
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Department of Clinical Research, University of Basel, 4031 Basel, Switzerland
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Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851115, Iran
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Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
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Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35209, USA
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Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
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Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, 4052 Basel, Switzerland
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School of Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran
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Author to whom correspondence should be addressed.
Life 2021, 11(1), 58; https://doi.org/10.3390/life11010058
Received: 10 October 2020 / Revised: 19 December 2020 / Accepted: 7 January 2021 / Published: 15 January 2021
(This article belongs to the Section Medical Research)
Background: A number of genes are associated with the incidence of non-syndromic cleft lip/palate (NSCL/P). Studies have shown a significant association between polymorphisms of ATP-binding cassette, sub-family A, member 4 (ABCA4) with the risk of NSCL/P. The present meta-analysis assessed the association between ABCA4 polymorphisms (rs560426 and rs481931) and the NSCL/P risk by reviewing case-control studies. Methods: Four databases (Scopus; Cochrane Library; Web of Science; and PubMed) were searched for articles published up to June 2020. The Review Manager 5.3 software was used to calculate the crude odds ratio (OR) and 95% confidence interval (CI). Both subgroup analyses for ethnicity and source of controls and a meta-regression related to publication year were conducted. Results: Of 94 retrieved studies, 12 were analyzed in this meta-analysis (2859 NSCL/P patients and 3792 controls for ABCA4 rs560426 polymorphism and 1333 NSCL/P patients and 1884 controls for ABCA4 rs481931 polymorphism). Overall, there was no significant association between both polymorphisms and the risk of NSCL/P. However, subgroup analysis demonstrated that there was a higher risk of NSCL/P for specific models: the allelic model (OR = 1.13; p = 0.03), the homozygote model (OR = 1.53; p = 0.04), and the recessive model (OR = 1.30; p = 0.03) in the Asian ethnicity for the rs560426 polymorphism. Conclusion: The findings confirmed that the NSCL/P risk was significantly associated with the G allele and GG genotype of rs560426 polymorphism but not for rs481931 polymorphism. There were no associations between both polymorphisms (rs560426 and rs481931) and the NSCL/P risk in those of European descent and the mixed ethnicities. View Full-Text
Keywords: ABCA4; polymorphism; variation; non-syndromic cleft lip/palate; meta-analysis ABCA4; polymorphism; variation; non-syndromic cleft lip/palate; meta-analysis
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MDPI and ACS Style

Imani, M.M.; Sadeghi, M.; Tadakamadla, S.K.; Brühl, A.; Sadeghi Bahmani, D.; Taheri, M.; Brand, S. Polymorphisms of ATP-Binding Cassette, Sub-Family A, Member 4 (rs560426 and rs481931) and Non-Syndromic Cleft Lip/Palate: A Meta-Analysis. Life 2021, 11, 58. https://doi.org/10.3390/life11010058

AMA Style

Imani MM, Sadeghi M, Tadakamadla SK, Brühl A, Sadeghi Bahmani D, Taheri M, Brand S. Polymorphisms of ATP-Binding Cassette, Sub-Family A, Member 4 (rs560426 and rs481931) and Non-Syndromic Cleft Lip/Palate: A Meta-Analysis. Life. 2021; 11(1):58. https://doi.org/10.3390/life11010058

Chicago/Turabian Style

Imani, Mohammad M., Masoud Sadeghi, Santosh K. Tadakamadla, Annette Brühl, Dena Sadeghi Bahmani, Mohammad Taheri, and Serge Brand. 2021. "Polymorphisms of ATP-Binding Cassette, Sub-Family A, Member 4 (rs560426 and rs481931) and Non-Syndromic Cleft Lip/Palate: A Meta-Analysis" Life 11, no. 1: 58. https://doi.org/10.3390/life11010058

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