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Mitochondrial Functionality in Inflammatory Pathology-Modulatory Role of Physical Activity

Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, 18100 Granada, Spain
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Life 2021, 11(1), 61; https://doi.org/10.3390/life11010061
Received: 21 December 2020 / Revised: 11 January 2021 / Accepted: 13 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Impaired Mitochondrial Bioenergetics under Pathological Conditions)
The incidence and severity of metabolic diseases can be reduced by introducing healthy lifestyle habits including moderate exercise. A common observation in age-related metabolic diseases is an increment in systemic inflammation (the so-called inflammaging) where mitochondrial reactive oxygen species (ROS) production may have a key role. Exercise prevents these metabolic pathologies, at least in part, due to its ability to alter immunometabolism, e.g., reducing systemic inflammation and by improving immune cell metabolism. Here, we review how exercise regulates immunometabolism within contracting muscles. In fact, we discuss how circulating and resident macrophages alter their function due to mitochondrial signaling, and we propose how these effects can be triggered within skeletal muscle in response to exercise. Finally, we also describe how exercise-induced mitochondrial adaptations can help to fight against virus infection. Moreover, the fact that moderate exercise increases circulating immune cells must be taken into account by public health agencies, as it may help prevent virus spread. This is of interest in order to face not only acute respiratory-related coronavirus (SARS-CoV) responsible for the COVID-19 pandemic but also for future virus infection challenges. View Full-Text
Keywords: exercise; mitochondria; immune system; metabolic disease; COVID-19 exercise; mitochondria; immune system; metabolic disease; COVID-19
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MDPI and ACS Style

Casuso, R.A.; Huertas, J.R. Mitochondrial Functionality in Inflammatory Pathology-Modulatory Role of Physical Activity. Life 2021, 11, 61. https://doi.org/10.3390/life11010061

AMA Style

Casuso RA, Huertas JR. Mitochondrial Functionality in Inflammatory Pathology-Modulatory Role of Physical Activity. Life. 2021; 11(1):61. https://doi.org/10.3390/life11010061

Chicago/Turabian Style

Casuso, Rafael A., and Jesús R. Huertas. 2021. "Mitochondrial Functionality in Inflammatory Pathology-Modulatory Role of Physical Activity" Life 11, no. 1: 61. https://doi.org/10.3390/life11010061

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