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Genes, Volume 10, Issue 5

May 2019 - 84 articles

Cover Story: Domestic dog, Canis lupus familiaris, breeds each have a distinct standard for their morphological appearance, with the coat being particularly prominent. In each breed, this consists of either a double or single layer of hair. Two single nucleotide changes within a regulatory region are suggestive causative variants, resulting in single coats within the dog lineage. Pictured is the Shetland Sheepdog, which is known for its lush double coat. Image courtesy of Dr. Dayna Dreger. View this paper.
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Articles (84)

  • Article
  • Open Access
14 Citations
4,914 Views
19 Pages

Comparative Transcriptome Analysis in Oilseed Rape (Brassica napus) Reveals Distinct Gene Expression Details between Nitrate and Ammonium Nutrition

  • Weijie Tang,
  • Xin He,
  • Lunwen Qian,
  • Feng Wang,
  • Zhenhua Zhang,
  • Chao Sun,
  • Liangbin Lin and
  • Chunyun Guan

22 May 2019

Nitrate (NO3−) and ammonium (NH4+) are the main inorganic nitrogen (N) sources absorbed by oilseed rape, a plant that exhibits genotypic differences in N efficiency. In our previous study, the biomass, N accumulation, and root architecture of t...

  • Article
  • Open Access
5 Citations
4,096 Views
15 Pages

Leaf Transcriptome Assembly of Protium copal (Burseraceae) and Annotation of Terpene Biosynthetic Genes

  • Gabriel Damasco,
  • Vikram S. Shivakumar,
  • Tracy M. Misciewicz,
  • Douglas C. Daly and
  • Paul V. A. Fine

22 May 2019

Plants in the Burseraceae are globally recognized for producing resins and essential oils with medicinal properties and have economic value. In addition, most of the aromatic and non-aromatic components of Burseraceae resins are derived from a variet...

  • Article
  • Open Access
14 Citations
4,270 Views
17 Pages

Expansion and Functional Divergence of Inositol Polyphosphate 5-Phosphatases in Angiosperms

  • Zaibao Zhang,
  • Yuting Li,
  • Zhaoyi Luo,
  • Shuwei Kong,
  • Yilin Zhao,
  • Chi Zhang,
  • Wei Zhang,
  • Hongyu Yuan and
  • Lin Cheng

22 May 2019

Inositol polyphosphate 5-phosphatase (5PTase), a key enzyme that hydrolyzes the 5′ position of the inositol ring, has essential functions in growth, development, and stress responses in plants, yeasts, and animals. However, the evolutionary his...

  • Article
  • Open Access
27 Citations
7,359 Views
15 Pages

22 May 2019

Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed vectors, named PEP for Pneumococcal Engineering Platform (PEP), employ an IPT...

  • Article
  • Open Access
40 Citations
5,166 Views
15 Pages

Heat Stress-Responsive Transcriptome Analysis in the Liver Tissue of Hu Sheep

  • Yaokun Li,
  • Lingxuan Kong,
  • Ming Deng,
  • Zhiquan Lian,
  • Yinru Han,
  • Baoli Sun,
  • Yongqing Guo,
  • Guangbin Liu and
  • Dewu Liu

22 May 2019

Heat stress has a severe effect on animal health and can reduce the productivity and reproductive efficiency; it is therefore necessary to explore the molecular mechanism involved in heat stress response, which is helpful for the cultivation of an an...

  • Article
  • Open Access
27 Citations
4,442 Views
16 Pages

22 May 2019

Hemp is a Pb-tolerant and Pb-accumulating plant and the study of its tolerance mechanisms could facilitate the breeding of hemp with enhanced Pb tolerance and accumulation. In the present study, we took advantage of sequential window acquisition of a...

  • Article
  • Open Access
11 Citations
4,810 Views
11 Pages

Detecting Schisandrae Chinensis Fructus and Its Chinese Patent Medicines with a Nucleotide Signature

  • Wenjun Jiang,
  • Li Ren,
  • Mengyue Guo,
  • Nitin Mantri,
  • Sha Zhao and
  • Xiaohui Pang

22 May 2019

Schisandrae Chinensis Fructus (Wuweizi) is often adulterated with Schisandrae Sphenantherae Fructus (Nanwuweizi) in the herbal market. This adulteration is a threat to clinical treatment and safety. In this study, we aimed to develop a nucleotide sig...

  • Article
  • Open Access
10 Citations
10,662 Views
17 Pages

Whole Genome Sequencing of Giant Schnauzer Dogs with Progressive Retinal Atrophy Establishes NECAP1 as a Novel Candidate Gene for Retinal Degeneration

  • Rebekkah J. Hitti,
  • James A. C. Oliver,
  • Ellen C. Schofield,
  • Anina Bauer,
  • Maria Kaukonen,
  • Oliver P. Forman,
  • Tosso Leeb,
  • Hannes Lohi,
  • Louise M. Burmeister and
  • David Sargan
  • + 1 author

21 May 2019

Canine progressive retinal atrophies (PRA) are genetically heterogeneous diseases characterized by retinal degeneration and subsequent blindness. PRAs are untreatable and affect multiple dog breeds, significantly impacting welfare. Three out of seven...

  • Article
  • Open Access
20 Citations
14,166 Views
9 Pages

Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White or Cream Coat Color in Dogs

  • Benoit Hédan,
  • Edouard Cadieu,
  • Nadine Botherel,
  • Caroline Dufaure de Citres,
  • Anna Letko,
  • Maud Rimbault,
  • Cord Drögemüller,
  • Vidhya Jagannathan,
  • Thomas Derrien and
  • Sheila Schmutz
  • + 2 authors

21 May 2019

White coat color in mammals has been selected several times during the domestication process. Numerous dog breeds are fixed for one form of white coat color that involves darkly pigmented skin. The genetic basis of this color, due to the absence of p...

  • Review
  • Open Access
25 Citations
10,348 Views
17 Pages

21 May 2019

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder caused by mutations in the CFTR gene. There are at least 346 disease-causing variants in the CFTR gene, but effective small-molecule therapies exist for only ~10% of them. One option to...

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Genes - ISSN 2073-4425