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Open AccessReview

Preserving Genome Integrity during the Early Embryonic DNA Replication Cycles

1
Laboratoire Surveillance et Stabilité du Génome, Institut de Génétique Humaine, UMR9002, CNRS, Université de Montpellier, 34090 Montpellier, France
2
Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, CA 94305-5441, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(5), 398; https://doi.org/10.3390/genes10050398
Received: 4 April 2019 / Revised: 21 May 2019 / Accepted: 21 May 2019 / Published: 24 May 2019
(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)
During the very early stages of embryonic development chromosome replication occurs under rather challenging conditions, including a very short cell cycle, absence of transcription, a relaxed DNA damage response and, in certain animal species, a highly contracted S-phase. This raises the puzzling question of how the genome can be faithfully replicated in such a peculiar metabolic context. Recent studies have provided new insights into this issue, and unveiled that embryos are prone to accumulate genetic and genomic alterations, most likely due to restricted cellular functions, in particular reduced DNA synthesis quality control. These findings may explain the low rate of successful development in mammals and the occurrence of diseases, such as abnormal developmental features and cancer. In this review, we will discuss recent findings in this field and put forward perspectives to further study this fascinating question. View Full-Text
Keywords: DNA damage; DNA damage tolerance; replication stress; Xenopus laevis; Drosophila melanogaster; zebrafish; Caenorabditis elegans; mouse embryonic stem cells; iPSCs DNA damage; DNA damage tolerance; replication stress; Xenopus laevis; Drosophila melanogaster; zebrafish; Caenorabditis elegans; mouse embryonic stem cells; iPSCs
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MDPI and ACS Style

Kermi, C.; Aze, A.; Maiorano, D. Preserving Genome Integrity during the Early Embryonic DNA Replication Cycles. Genes 2019, 10, 398.

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