Gene-Diet Interactions in Obesity

Dear Colleagues,

Since antiquity, we have the knowledge that diet is key for health. In the late 20^th century the study of the interactions between genes and nutrients, known as Nutrigenomics, started to show enormous potential against disease. To date, this strategy has been successfully used to prevent the development of particular monogenic diseases such as phenylketonuria, celiac disease and familial hypercholesterolemia. Nevertheless, there is a lack of solid evidence regarding multifactorial diseases such as cancer, obesity, cardiovascular disease and diabetes. Furthermore, not only nutrients play a role in health. Dietary components with bioactive properties such as phytochemicals showed beneficial effects in several disease models.

Thus far, it remains a challenge to elucidate the role of diet regarding its composition in macronutrients, micronutrients and non-nutrients in order to optimize its use to benefit human health.

This Special Issue welcomes manuscripts from human and animal studies focused on evaluating the influence of diet and individual dietary components on gene regulation in both physiological and non-physiological conditions (such us obesity, diabetes, hypertension or cancer), as well as in vitro studies aimed to elucidate the potential molecular mechanisms of diet and gene interactions.

Dr. Gerard Aragonès

Dr. Maria Ibars

Guest Editors

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