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Genes, Volume 10, Issue 6

June 2019 - 76 articles

Cover Story: Pet dogs are potentially the most powerful natural model for many human diseases, including cancer, autoimmune disorders and psychiatric diseases (Image courtesy of Trish McMillan). In this issue, Megquier et al introduce the Barkbase data portal, a new epigenomic resource for dog research. Barkbase catalogs functional genomic regions in dozens of tissues from six adult dogs, who differed in ancestry, age, and size, as well as from embryos at four developmental time points. Modeled on similar resources in human genomics, this new portal supports efforts to identify and investigate canine genetic variants associated with traits and diseases. All data is freely accessible at barkbase.org with additional data in production. View this paper.
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Articles (76)

  • Review
  • Open Access
6 Citations
5,035 Views
14 Pages

Electromagnetic Fields, Genomic Instability and Cancer: A Systems Biological View

  • Jonne Naarala,
  • Mikko Kolehmainen and
  • Jukka Juutilainen

25 June 2019

This review discusses the use of systems biology in understanding the biological effects of electromagnetic fields, with particular focus on induction of genomic instability and cancer. We introduce basic concepts of the dynamical systems theory such...

  • Article
  • Open Access
21 Citations
8,788 Views
27 Pages

The Genomic Makeup of Nine Horse Populations Sampled in the Netherlands

  • Anouk Schurink,
  • Merina Shrestha,
  • Susanne Eriksson,
  • Mirte Bosse,
  • Henk Bovenhuis,
  • Willem Back,
  • Anna M. Johansson and
  • Bart J. Ducro

25 June 2019

The spectrum of modern horse populations encompasses populations with a long history of development in isolation and relatively recently formed types. To increase our understanding of the evolutionary history and provide information on how to optimal...

  • Article
  • Open Access
8 Citations
3,349 Views
12 Pages

Survey of the Bradysia odoriphaga Transcriptome Using PacBio Single-Molecule Long-Read Sequencing

  • Haoliang Chen,
  • Lulu Lin,
  • Minghui Xie,
  • Yongzhi Zhong,
  • Guangling Zhang and
  • Weihua Su

25 June 2019

The damage caused by Bradysia odoriphaga is the main factor threatening the production of vegetables in the Liliaceae family. However, few genetic studies of B. odoriphaga have been conducted because of a lack of genomic resources. Many long-read seq...

  • Article
  • Open Access
10 Citations
5,237 Views
15 Pages

24 June 2019

The vetiver essential oil from Chrysopogon zizanioides contains fragrant sesquiterpenes used widely in the formulation of nearly 20% of men’s cosmetics. The growing demand and issues in the supply have raised interest in the microbial productio...

  • Article
  • Open Access
17 Citations
5,506 Views
14 Pages

Genome-Wide Analysis of Long Non-Coding RNA Profiles in Canine Oral Melanomas

  • Christophe Hitte,
  • Céline Le Béguec,
  • Edouard Cadieu,
  • Valentin Wucher,
  • Aline Primot,
  • Anaïs Prouteau,
  • Nadine Botherel,
  • Benoît Hédan,
  • Kerstin Lindblad-Toh and
  • Catherine André
  • + 1 author

23 June 2019

Mucosal melanomas (MM) are rare aggressive cancers in humans, and one of the most common forms of oral cancers in dogs. Similar biological and histological features are shared between MM in both species, making dogs a powerful model for comparative o...

  • Article
  • Open Access
34 Citations
6,355 Views
11 Pages

Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box

  • Xinying Wang,
  • Yukiko Miyazaki,
  • Daniel Ken Inaoka,
  • Endah Dwi Hartuti,
  • Yoh-Ichi Watanabe,
  • Tomoo Shiba,
  • Shigeharu Harada,
  • Hiroyuki Saimoto,
  • Jeremy Nicholas Burrows and
  • Francisco Javier Gamo Benito
  • + 2 authors

21 June 2019

Malaria is one of the three major global health threats. Drug development for malaria, especially for its most dangerous form caused by Plasmodium falciparum, remains an urgent task due to the emerging drug-resistant parasites. Exploration of novel a...

  • Article
  • Open Access
41 Citations
5,187 Views
20 Pages

Genome-Wide Identification and Expression Analyses of the Chitinases under Cold and Osmotic Stress in Ammopiptanthus nanus

  • Shilin Cao,
  • Ying Wang,
  • Zhiqiang Li,
  • Wei Shi,
  • Fei Gao,
  • Yijun Zhou,
  • Genfa Zhang and
  • Jinchao Feng

21 June 2019

Chitinase is a kind of hydrolase with chitin as a substrate and is proposed to play an essential role in plant defense system by functioning against fungal pathogens through degrading chitin. Recent studies indicated chitinase is also involved in abi...

  • Article
  • Open Access
18 Citations
4,447 Views
17 Pages

21 June 2019

Class III peroxidases (PODs), commonly known as secretable class III plant peroxidases, are plant-specific enzymes that play critical roles in not only plant growth and development but also the responses to biotic and abiotic stress. In this study, w...

  • Communication
  • Open Access
33 Citations
5,465 Views
11 Pages

Immunophenotyping of a Stromal Vascular Fraction from Microfragmented Lipoaspirate Used in Osteoarthritis Cartilage Treatment and Its Lipoaspirate Counterpart

  • Denis Polancec,
  • Lucija Zenic,
  • Damir Hudetz,
  • Igor Boric,
  • Zeljko Jelec,
  • Eduard Rod,
  • Trpimir Vrdoljak,
  • Andrea Skelin,
  • Mihovil Plecko and
  • Mirjana Turkalj
  • + 2 authors

21 June 2019

Osteoarthritis (OA) is a degenerative joint disease accompanied by pain and loss of function. Adipose tissue harbors mesenchymal stem/stromal cells (MSC), or medicinal signaling cells as suggested by Caplan (Caplan, 2017), used in autologous transpla...

  • Article
  • Open Access
22 Citations
5,865 Views
24 Pages

Identification of Stress Associated microRNAs in Solanum lycopersicum by High-Throughput Sequencing

  • María José López-Galiano,
  • Vicente Sentandreu,
  • Amparo C. Martínez-Ramírez,
  • Carolina Rausell,
  • M. Dolores Real,
  • Gemma Camañes,
  • Omar Ruiz-Rivero,
  • Oscar Crespo-Salvador and
  • Inmaculada García-Robles

21 June 2019

Tomato (Solanum lycopersicum) is one of the most important crops around the world and also a model plant to study response to stress. High-throughput sequencing was used to analyse the microRNA (miRNA) profile of tomato plants undergoing five biotic...

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Genes - ISSN 2073-4425Creative Common CC BY license