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Cells, Volume 13, Issue 4

February-2 2024 - 74 articles

Cover Story: Vasoactive intestinal peptides (VIPs) are widely distributed in the central and peripheral nervous, digestive and respiratory systems. VIPs contribute to an extensive range of physiological and pathological processes and control neuronal, epithelial, and endocrine cell function. In the current publication, we focused our studies on VIPs and VIP receptor-induced esophageal inflammation and remodeling. Our findings provided evidence that eosinophilic and mast cell accumulation in response to nerve cell-derived mediator VIP and receptor CRTH2 interaction promotes motility disfunction in eosinophilic esophagitis (EoE). Most importantly, we showed that eosinophil and mast cell accumulation, which are directly responsible for esophageal motility dysfunction improves  following CRTH2 antagonist treatment in experimentally induced chronic EoE. View this paper
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Articles (74)

  • Article
  • Open Access
6 Citations
4,042 Views
17 Pages

19 February 2024

Glioblastoma multiforme (GBM) is an aggressive type of brain tumor that has limited treatment options. Current standard therapies, including surgery followed by radiotherapy and chemotherapy, are not very effective due to the rapid progression and re...

  • Article
  • Open Access
2 Citations
2,986 Views
12 Pages

Comparison of the Single Cell Immune Landscape between Subjects with High Mycobacterium tuberculosis Bacillary Loads during Active Pulmonary Tuberculosis and Household Members with Latent Tuberculosis Infection

  • Supitcha Kamolratanakul,
  • Wassawon Ariyanon,
  • Kanyarat Udompornpitak,
  • Thansita Bhunyakarnjanarat,
  • Asada Leelahavanichkul,
  • Jittima Dhitavat,
  • Polrat Wilairatana and
  • Wiwat Chancharoenthana

19 February 2024

It is unclear how the immune system controls the transition from latent tuberculosis (TB) infection (LTBI) to active pulmonary infection (PTB). Here, we applied mass spectrometry cytometry time-of-flight (CyTOF) analysis of peripheral blood mononucle...

  • Review
  • Open Access
7 Citations
5,462 Views
17 Pages

Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma

  • Alberto Repici,
  • Alessio Ardizzone,
  • Fabiola De Luca,
  • Lorenzo Colarossi,
  • Angela Prestifilippo,
  • Gabriele Pizzino,
  • Irene Paterniti,
  • Emanuela Esposito and
  • Anna Paola Capra

19 February 2024

Brain tumors are a diverse collection of neoplasms affecting the brain with a high prevalence rate in people of all ages around the globe. In this pathological context, glioblastoma, a form of glioma that belongs to the IV-grade astrocytoma group, is...

  • Article
  • Open Access
5 Citations
3,030 Views
21 Pages

Pharmacological Stimulation of Soluble Guanylate Cyclase Counteracts the Profibrotic Activation of Human Conjunctival Fibroblasts

  • Bianca Saveria Fioretto,
  • Irene Rosa,
  • Elena Andreucci,
  • Rita Mencucci,
  • Mirca Marini,
  • Eloisa Romano and
  • Mirko Manetti

18 February 2024

Conjunctival fibrosis is a serious clinical concern implicated in a wide spectrum of eye diseases, including outcomes of surgery for pterygium and glaucoma. It is mainly driven by chronic inflammation that stimulates conjunctival fibroblasts to diffe...

  • Communication
  • Open Access
7 Citations
2,597 Views
13 Pages

Effect of LDL Extracted from Human Plasma on Membrane Stiffness in Living Endothelial Cells and Macrophages via Scanning Ion Conductance Microscopy

  • Diana Kiseleva,
  • Vasilii Kolmogorov,
  • Vadim Cherednichenko,
  • Ulyana Khovantseva,
  • Anastasia Bogatyreva,
  • Yuliya Markina,
  • Petr Gorelkin,
  • Alexander Erofeev and
  • Alexander Markin

18 February 2024

Mechanical properties of living cells play a crucial role in a wide range of biological functions and pathologies, including atherosclerosis. We used low-stress Scanning Ion-Conductance Microscopy (SICM) correlated with confocal imaging and demonstra...

  • Review
  • Open Access
31 Citations
6,717 Views
20 Pages

Regulatory B Cells—Immunopathological and Prognostic Potential in Humans

  • Johanna Veh,
  • Carolin Ludwig,
  • Hubert Schrezenmeier and
  • Bernd Jahrsdörfer

18 February 2024

The aim of the following review is to shed light on the putative role of regulatory B cells (Bregs) in various human diseases and highlight their potential prognostic and therapeutic relevance in humans. Regulatory B cells are a heterogeneous group o...

  • Article
  • Open Access
1 Citations
2,750 Views
12 Pages

18 February 2024

Acanthocephalans are dioecious parasites that gain sexual maturity in the alimentary canal of their definitive hosts (gnathostome vertebrates). This initial survey by light and transmission electron microscopy was conducted on the functional organiza...

  • Article
  • Open Access
5 Citations
2,813 Views
14 Pages

Anti-Apoptotic and Anti-Inflammatory Properties of Grapefruit IntegroPectin on Human Microglial HMC3 Cell Line

  • Miriana Scordino,
  • Giulia Urone,
  • Monica Frinchi,
  • Chiara Valenza,
  • Angela Bonura,
  • Chiara Cipollina,
  • Rosaria Ciriminna,
  • Francesco Meneguzzo,
  • Mario Pagliaro and
  • Giuseppa Mudò
  • + 1 author

18 February 2024

In this study, we investigated the beneficial effects of grapefruit IntegroPectin, derived from industrial waste grapefruit peels via hydrodynamic cavitation, on microglia cells exposed to oxidative stress conditions. Grapefruit IntegroPectin fully c...

  • Review
  • Open Access
12 Citations
3,645 Views
15 Pages

Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility

  • Leigh Naylor-Adamson,
  • Thomas W. Price,
  • Zoe Booth,
  • Graeme J. Stasiuk and
  • Simon D. J. Calaminus

18 February 2024

Quantum dots (QDs) are semi-conducting nanoparticles that have been developed for a range of biological and non-biological functions. They can be tuned to multiple different emission wavelengths and can have significant benefits over other fluorescen...

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Cells - ISSN 2073-4409