Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease
Abstract
:1. Cellular Senescence
2. Mitochondrial Abnormalities in Cardiovascular Diseases
2.1. Energy Starvation and Oxidative Stress
2.2. Mitochondria Dynamics Imbalance
2.3. Cell Apoptosis and Mitophagy
3. Mitochondria Dysfunction, Senescence, and Inflammation in CVD
4. Mitochondrial and Senescent Cells Targeted Therapies for CVD
4.1. Therapeutically Targeting Mitochondrial Dysfunction
4.2. Senolytics, Senomorphics and Future Approaches
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Camacho-Encina, M.; Booth, L.K.; Redgrave, R.E.; Folaranmi, O.; Spyridopoulos, I.; Richardson, G.D. Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease. Cells 2024, 13, 353. https://doi.org/10.3390/cells13040353
Camacho-Encina M, Booth LK, Redgrave RE, Folaranmi O, Spyridopoulos I, Richardson GD. Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease. Cells. 2024; 13(4):353. https://doi.org/10.3390/cells13040353
Chicago/Turabian StyleCamacho-Encina, Maria, Laura K. Booth, Rachael E. Redgrave, Omowumi Folaranmi, Ioakim Spyridopoulos, and Gavin D. Richardson. 2024. "Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease" Cells 13, no. 4: 353. https://doi.org/10.3390/cells13040353