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Cancers
Special Issues
State-of-the-Art Research on Gastric Cancer Surgery
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State-of-the-Art Research on Gastric Cancer Surgery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 539

Special Issue Editors

Dr. Georgios D. Lianos

E-Mail Website
Guest Editor
Department of Surgery, University of Ioannina, Ioannina, Greece
Interests: surgical oncology; gastric cancer; colon cancer; minimally invasive surgery; emergency surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Dimitrios Schizas

E-Mail Website
Guest Editor
First Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
Interests: esophageal cancer; gastric cancer; pancreatic cancer; immunotherapy; personalized medicine; surgery; medical education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our upcoming Special Issue titled "State-of-the-Art Research on Gastric Cancer Surgery". This Special Issue will focus on advancements in personalized surgical oncology, highlighting the significance of tailored treatment strategies in improving patient outcomes. Gastric cancer surgery is evolving rapidly with the introduction of minimally invasive techniques, innovative non-invasive biomarkers, and next-generation sequencing analyses.

This Special Issue will explore various aspects of gastric cancer surgery, including the concept of total mesogastric excision, gastric juice analyses, anastomoses with indocyanine control, and lymph node mapping. Additionally, we will cover innovative technical issues that enhance surgical precision and patient care.

We welcome original research articles and reviews in areas such as personalized surgical oncology, minimally invasive techniques, innovative non-invasive biomarkers, gastric juice analyses, total mesogastric excision concept, anastomoses with indocyanine control, lymph node mapping, next-generation sequencing analyses, and other related topics.

We look forward to receiving your valuable contributions to this Special Issue, which will advance the field of gastric cancer surgery and provide a comprehensive resource for clinicians and researchers.

Dr. Georgios D. Lianos
Dr. Dimitrios Schizas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized surgical oncology
  • minimally invasive techniques
  • innovative non-invasive biomarkers
  • gastric juice analyses
  • total mesogastric excision
  • indocyanine green (ICG) anastomoses
  • lymph node mapping
  • next-generation sequencing
  • surgical innovation
  • gastric cancer treatment

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Published Papers (1 paper)

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20 pages, 1199 KiB  
Systematic Review
Impact of Duodenal Stump Reinforcement in Preventing Duodenal Stump Fistula/Leakage After Distal or Total Gastrectomy for Malignant Disease: A Meta-Analysis of Comparative Studies
by Maurizio Zizzo, Andrea Morini, Magda Zanelli, Giuseppe Broggi, Francesca Sanguedolce, Nektarios I. Koufopoulos, Andrea Palicelli, Lucia Mangone, Massimiliano Fabozzi, Mario Giuffrida, Candida Bonelli and Federico Marchesi
Cancers 2025, 17(11), 1735; https://doi.org/10.3390/cancers17111735 - 22 May 2025
Viewed by 173
Abstract
Background/Objectives: Duodenal stump fistula (DSF) is one of the most feared postoperative complications in gastric cancer surgery. It has a 1.6–5% incidence rate and correlates with potentially high rates of morbidity (75%) and mortality (16–20%). The absence of duodenal stump reinforcement is [...] Read more.
Background/Objectives: Duodenal stump fistula (DSF) is one of the most feared postoperative complications in gastric cancer surgery. It has a 1.6–5% incidence rate and correlates with potentially high rates of morbidity (75%) and mortality (16–20%). The absence of duodenal stump reinforcement is considered one of the main risk factors. Our meta-analysis aimed to provide updated evidence by comparing DSF rates among patients who underwent distal or total gastrectomy for malignant gastric disease with or without reinforcement of the duodenal stump. Methods: We performed a systematic review following the PRISMA guidelines. PubMed/MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library databases were used to identify articles of interest. Meta-analysis was performed by using RevMan Version 5.4. Results: The six included comparative studies (19,527 patients: 11,545 reinforcement group versus 7982 control group) covered an approximately 20-year study period (2005–2023). All the studies included were observational in nature. Meta-analysis of pooled results showed that, compared to the control group, the reinforcement group recorded a statistically significant lower DSF rate (OR: 0.32, 95% CI: 0.17, 0.60, p = 0.0004). Considering secondary outcomes, no statistically significant differences were identified between the two groups in terms of operative time, EBL, overall postoperative complications, and length of hospital stay. Just major postoperative complications were considerably lower in the reinforcement group compared to the control group (OR: 0.66, 95% CI: 0.43, 0.99, p = 0.04). Conclusions: Duodenal stump reinforcement appears to reduce the rate of DSF after distal or total gastrectomy for malignant gastric disease. Given the significant biases among meta-analyzed studies, our results require careful interpretation. Further randomized, possibly multicenter trials may turn out to be of paramount importance in confirming our results. Full article
(This article belongs to the Special Issue State-of-the-Art Research on Gastric Cancer Surgery)
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