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Cancers, Volume 16, Issue 12

June-2 2024 - 125 articles

Cover Story: The uncontrolled growth of cancer cells results in elevated reactive oxygen species (ROS) levels due to their intense metabolic activity and mitochondria malfunction. This altered redox balance presents a therapeutic opportunity for targeting cancer cells via ROS modulation. This review explores a diverse array of chemical reagents that generate H2O2, the most stable ROS, in cancer cells as a potential mechanism for their anticancer activities and selectivity. It will discuss in depth their mechanisms of function, potential preclinical and clinical applications and recent advancements, as well as their potential for personalized treatments and their use in combination therapies, whilst simultaneously acknowledging potential roadblocks, such as selectivity, tumor heterogeneity and safety. View this paper
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Articles (125)

  • Review
  • Open Access
15 Citations
4,349 Views
37 Pages

Gynotoxic Effects of Chemotherapy and Potential Protective Mechanisms

  • Anna Markowska,
  • Michał Antoszczak,
  • Janina Markowska and
  • Adam Huczyński

20 June 2024

Chemotherapy is one of the leading cancer treatments. Unfortunately, its use can contribute to several side effects, including gynotoxic effects in women. Ovarian reserve suppression and estrogen deficiency result in reduced quality of life for cance...

  • Article
  • Open Access
1,551 Views
14 Pages

20 June 2024

In clinical trials, laboratory values are assessed with high frequency. This can be stressful for patients, resource intensive, and difficult to implement, for example in office-based settings. In the prospective, multicentre phase 2 TITAN-RCC trial...

  • Article
  • Open Access
2 Citations
2,428 Views
11 Pages

Phase II Clinical Trial of Second Course of Stereotactic Body Radiotherapy for Spinal Metastases

  • Kei Ito,
  • Yujiro Nakajima,
  • Kentaro Taguchi,
  • Hiroaki Ogawa,
  • Makoto Saito and
  • Keiko Nemoto Murofushi

20 June 2024

Purpose: The optimal method for the second course of stereotactic body radiotherapy (SBRT) for spinal metastases remains poorly established. This single-center, single-arm, phase II trial was conducted to propose a safe and effective salvage spine SB...

  • Article
  • Open Access
5 Citations
2,102 Views
20 Pages

Exploring miRNA Profiles in Colon Cancer: A Focus on miR101-3p, miR106a-5p, and miR326

  • Constantin-Dan Tâlvan,
  • Elena-Teodora Tâlvan,
  • Călin Ilie Mohor,
  • Liviuța Budișan,
  • Valentin Grecu,
  • Manuela Mihalache,
  • Oana Zănoagă,
  • Sergiu Chira,
  • Ioana Berindan-Neagoe and
  • Victor Cristea
  • + 1 author

20 June 2024

Early diagnosis and prognosis of cancer progression through biomarker profiling are crucial in managing colon cancer patients. Our research aimed to investigate the expression of miR-101-3p, miR-106a-5p, and miR-326 in tumor and adjacent healthy tiss...

  • Article
  • Open Access
6,860 Views
18 Pages

20 June 2024

Human papillomavirus (HPV) has been implicated in various cancers, including those affecting the skin. The study assessed the long-term risk of skin cancer associated with HPV infection in Taiwan region, using data from the National Health Insurance...

  • Review
  • Open Access
3 Citations
2,782 Views
18 Pages

Comprehensive Insights into Chondroblastoma Metastasis: Metastatic Patterns and Therapeutic Approaches

  • Ramy Samargandi,
  • Abrar Bafail,
  • Louis-Romée Le Nail and
  • Julien Berhouet

20 June 2024

Chondroblastoma metastasis, though rare, represents a clinically significant and notably important aspect of bone tumors. Understanding its epidemiological characteristics, pathological features, and treatment modalities, despite its infrequency, is...

  • Article
  • Open Access
3 Citations
1,807 Views
15 Pages

SMARCD3 Overexpression Promotes Epithelial–Mesenchymal Transition in Gastric Cancer

  • Sun Yi Park,
  • Ji-Ho Park,
  • Jung Wook Yang,
  • Eun-Jung Jung,
  • Young-Tae Ju,
  • Chi-Young Jeong,
  • Ju-Yeon Kim,
  • Taejin Park,
  • Tae-Han Kim and
  • Miyeong Park
  • + 2 authors

20 June 2024

This study investigates the role of SMARCD3 in gastric cancer by comparing its expression in signet ring cell (SRC) and well-differentiated (WD) groups within gastric cancer cell lines and tissues. We observed elevated SMARCD3 levels in the SRC group...

  • Article
  • Open Access
1 Citations
2,435 Views
32 Pages

Functional and Disability Outcomes in NSCLC Patients Post-Lobectomy Undergoing Pulmonary Rehabilitation: A Biopsychosocial Approach

  • Agnieszka Zawadzka-Fabijan,
  • Artur Fabijan,
  • Mariusz Łochowski,
  • Łukasz Pryt,
  • Bartosz Polis,
  • Krzysztof Zakrzewski,
  • Jolanta Ewa Kujawa and
  • Józef Kozak

20 June 2024

Worldwide, lung cancer remains the predominant cause of cancer cases and deaths and poses significant health challenges, with surgical resection being a key treatment. Post-surgery, patients often experience functional impairments. This study aimed t...

  • Review
  • Open Access
9 Citations
5,389 Views
28 Pages

20 June 2024

CtDNA is emerging as a non-invasive clinical detection method for several cancers, including genitourinary (GU) cancers such as prostate cancer, bladder cancer, and renal cell carcinoma (RCC). CtDNA assays have shown promise in early detection of GU...

  • Article
  • Open Access
1 Citations
1,697 Views
9 Pages

Musculoskeletal Disorders Related to Upper Limb Disability after One-Year Lung Cancer Resection

  • Javier Martín Núñez,
  • Julia Raya Benítez,
  • Florencio Quero Valenzuela,
  • Andrés Calvache Mateo,
  • Alba Navas Otero,
  • Alejandro Heredia Ciuró and
  • Marie Carmen Valenza

19 June 2024

Lung resection represents the main curative treatment in lung cancer; however, this surgical process leads to several disorders in tissues and organs. Previous studies have reported cardiovascular, pulmonary, and muscular disturbances that affect the...

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Cancers - ISSN 2072-6694