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Cancers, Volume 11, Issue 12 (December 2019)
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Cover Story (view full-size image) Despite being an extremely inefficient process, the high burden of lethality in metastatic prostate [...] Read more. Despite being an extremely inefficient process, the high burden of lethality in metastatic prostate cancer patients can be attributed to a plethora of strategies utilized by the cancer cells that have escaped the primary tumor. Striking similarities exist between the means used to achieve metastasis and military combat, where oftentimes, the modus operandi involves the creative use of tactics to overcome the host systems. These strategies include priming the metastatic sites ahead of colonization, targeting specific organs, outsmarting the host immune surveillance, lying in a dormant state at the metastatic site for prolonged periods, and widespread reprogramming of gene expression. This review provides a perspective for understanding metastasis from the standpoint of military combat, wherein strategic maneuvering instead of brute force often plays a decisive role in the outcome. View this paper