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Open AccessArticle

Magnetic Silica-Coated Iron Oxide Nanochains as Photothermal Agents, Disrupting the Extracellular Matrix, and Eradicating Cancer Cells

1
Institute of Pharmacology and Structural Biology, 205 Route de Narbonne, 31400 Toulouse, France
2
Department for Materials Synthesis, Jožef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia
3
Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, 1000 Ljubljana, Slovenia
4
Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, Bâtiment Condorcet, Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris, France
5
Centre de Microscopie Electronique Appliquée à la Biologie (CMEAB), Faculté de Médecine Rangueil, 133 Route de Narbonne, 31400 Toulouse, France
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(12), 2040; https://doi.org/10.3390/cancers11122040
Received: 30 October 2019 / Revised: 11 December 2019 / Accepted: 13 December 2019 / Published: 17 December 2019
(This article belongs to the Special Issue Cancer Nanomedicine)
Cancerous cells and the tumor microenvironment are among key elements involved in cancer development, progression, and resistance to treatment. In order to tackle the cells and the extracellular matrix, we herein propose the use of a class of silica-coated iron oxide nanochains, which have superior magnetic responsiveness and can act as efficient photothermal agents. When internalized by different cancer cell lines and normal (non-cancerous) cells, the nanochains are not toxic, as assessed on 2D and 3D cell culture models. Yet, upon irradiation with near infrared light, the nanochains become efficient cytotoxic photothermal agents. Besides, not only do they generate hyperthermia, which effectively eradicates tumor cells in vitro, but they also locally melt the collagen matrix, as we evidence in real-time, using engineered cell sheets with self-secreted extracellular matrix. By simultaneously acting as physical (magnetic and photothermal) effectors and chemical delivery systems, the nanochain-based platforms offer original multimodal possibilities for prospective cancer treatment, affecting both the cells and the extracellular matrix. View Full-Text
Keywords: magnetic silica-coated iron oxide nanochains; nanoparticles; photothermal treatment; hyperthermia; cancer; collagen; cellular microenvironment magnetic silica-coated iron oxide nanochains; nanoparticles; photothermal treatment; hyperthermia; cancer; collagen; cellular microenvironment
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MDPI and ACS Style

Kolosnjaj-Tabi, J.; Kralj, S.; Griseti, E.; Nemec, S.; Wilhelm, C.; Plan Sangnier, A.; Bellard, E.; Fourquaux, I.; Golzio, M.; Rols, M.-P. Magnetic Silica-Coated Iron Oxide Nanochains as Photothermal Agents, Disrupting the Extracellular Matrix, and Eradicating Cancer Cells. Cancers 2019, 11, 2040.

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