Special Issue "Targeting Wnt Signaling in Cancer"

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Dr. Robert M. Kypta

Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK; Centre for Cooperative Research in Biosciences, CIC bioGUNE, 48160 Derio, Spain
Website 1 | Website 2 | E-Mail
Interests: Wnt and TGF-β signaling in cancer, neural stem cell differentiation

Special Issue Information

Dear Colleagues,

A wide variety of approaches have been used to control Wnt signaling, not only in cancer but also in other diseases where Wnt signaling has gone awry. These approaches include prevention of ligand secretion, inhibition of receptor function, modulation of effector protein stability, and disruption of transcription factor complexes. This Special Issue seeks to highlight some of the achievements that have been made in identifying drugs that target Wnt signaling, in clinical trials involving Wnt inhibitors, and in determining potential new targets and tools that might be used to impact Wnt signaling in cancer in the future.

Dr. Robert M. Kypta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Wnt signaling
  • small-molecule modulators
  • function-blocking antibodies
  • clinical trials
  • drug resistance
  • combination therapy
  • natural compounds

Published Papers (1 paper)

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Review

Open AccessReview Targeting Wnt Signaling via Notch in Intestinal Carcinogenesis
Cancers 2019, 11(4), 555; https://doi.org/10.3390/cancers11040555
Received: 27 March 2019 / Revised: 15 April 2019 / Accepted: 16 April 2019 / Published: 18 April 2019
PDF Full-text (2243 KB) | HTML Full-text | XML Full-text
Abstract
Proliferation and differentiation of intestinal epithelial cells is assisted by highly specialized and well-regulated signaling cascades. The Wnt pathway, which is one of the fundamental pathways in the intestine, contributes to the organization of proliferative intestinal crypts by positioning and cycling of intestinal [...] Read more.
Proliferation and differentiation of intestinal epithelial cells is assisted by highly specialized and well-regulated signaling cascades. The Wnt pathway, which is one of the fundamental pathways in the intestine, contributes to the organization of proliferative intestinal crypts by positioning and cycling of intestinal stem cells and their derivatives. The Wnt pathway promotes differentiation of intestinal secretory cell types along the crypt-plateau and crypt-villus axis. In contrast to the Wnt pathway, the intestinal Notch cascade participates in cellular differentiation and directs progenitor cells towards an absorptive fate with diminished numbers of Paneth and goblet cells. Opposing activities of Notch and Wnt signaling in the regulation of intestinal stem cells and the enterocytic cell fate have been elucidated recently. In fact, targeting Notch was able to overcome tumorigenesis of intestinal adenomas, prevented carcinogenesis, and counteracted Paneth cell death in the absence of caspase 8. At present, pharmacological Notch inhibition is considered as an interesting tool targeting the intrinsic Wnt pathway activities in intestinal non-neoplastic disease and carcinogenesis. Full article
(This article belongs to the Special Issue Targeting Wnt Signaling in Cancer)
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