Toxins, Volume 9, Issue 7 (July 2017) – 37 articles
Cover Story (view full-size image):
The mode of action of cyclo(L-Ala-L-Pro), a selective aflatoxin production inhibitor, in inhibiting aflatoxin production of Aspergillus flavus was clarified. Cyclo(L-Ala-L-Pro) specifically bound to a glutathione S-transferase (GST) of the fungus (AfGST) and inhibited its GST activity. Ethacrynic acid, a known GST inhibitor, inhibited the GST activity of AfGST and aflatoxin production of the fungus. Ethacrynic acid reduced the expression level of AflR, a key regulatory protein for aflatoxin production, similar to cyclo(L-Ala-L-Pro). These results suggest that cyclo(L-Ala-L-Pro) inhibits aflatoxin production by affecting GST function in A. flavus, and that AfGST inhibitors are possible candidates as selective aflatoxin production inhibitors. View this paper
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader
to open them.
Previous Issue
Next Issue