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Toxins, Volume 9, Issue 7 (July 2017)
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Cover Story (view full-size image) The mode of action of cyclo(L-Ala-L-Pro), a selective aflatoxin production inhibitor, in inhibiting [...] Read more. The mode of action of cyclo(L-Ala-L-Pro), a selective aflatoxin production inhibitor, in inhibiting aflatoxin production of Aspergillus flavus was clarified. Cyclo(L-Ala-L-Pro) specifically bound to a glutathione S-transferase (GST) of the fungus (AfGST) and inhibited its GST activity. Ethacrynic acid, a known GST inhibitor, inhibited the GST activity of AfGST and aflatoxin production of the fungus. Ethacrynic acid reduced the expression level of AflR, a key regulatory protein for aflatoxin production, similar to cyclo(L-Ala-L-Pro). These results suggest that cyclo(L-Ala-L-Pro) inhibits aflatoxin production by affecting GST function in A. flavus, and that AfGST inhibitors are possible candidates as selective aflatoxin production inhibitors. View this paper