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Toxins, Volume 9, Issue 2 (February 2017)
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Cover Story (view full-size image) Shiga toxins comprise a family of related bacterial protein toxins which bind to their receptor on [...] Read more. Shiga toxins comprise a family of related bacterial protein toxins which bind to their receptor on the cell surface and then become endocytosed and transported retrogradely to the endoplasmic reticulum, where the enzymatically active moiety of the toxin is released to the cytosol and inhibits proteins synthesis. The top right corner: the structure of Shiga toxin as determined by X-ray crystallography. Fluorescent confocal image of HEp-2 cells treated with Shiga toxin B (receptor binding moiety) for 30 min 37oC. Red: Shiga toxin B; green: Golgi protein giantin; blue: nucleus (DAPI). View this paper.