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Toxins, Volume 8, Issue 11

November 2016 - 41 articles

Cover Story: C. perfringens type D strain CN3718 attachment to Caco-2 cells. C. perfringens CN3718 produces sialidases named NanH, NanI and NanJ. When the wild-type strain, an isogenic triple sialidase mutant, or a NanI complementing strain were incubated with human Caco-2 cells and then gently washed, the wild-type and complementing strain attached well to Caco-2 cells, as detected by immunofluorescence microscopy. However, the isogenic mutant with all three sialidase genes disrupted attached poorly to Caco-2 cells. Similar complementation of the triple sialidase mutant to express NanH or NanJ did not increase attachment. Green:C. perfringens; Red: Caco-2 cells. From: PLoS Pathogens 2011 Dec;7(12):e1002429.View this paper.
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Articles (41)

  • Review
  • Open Access
47 Citations
13,446 Views
24 Pages

Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines

  • Marcos Roberto A. Ferreira,
  • Gustavo Marçal S. G. Moreira,
  • Carlos Eduardo P. da Cunha,
  • Marcelo Mendonça,
  • Felipe M. Salvarani,
  • Ângela N. Moreira and
  • Fabricio R. Conceição

21 November 2016

Clostridium perfringens is a spore-forming, commensal, ubiquitous bacterium that is present in the gastrointestinal tract of healthy humans and animals. This bacterium produces up to 18 toxins. The species is classified into five toxinotypes (A–E) ac...

  • Article
  • Open Access
8 Citations
5,572 Views
12 Pages

Integrating scFv into xMAP Assays for the Detection of Marine Toxins

  • Lisa C. Shriver-Lake,
  • Jinny L. Liu,
  • P. Audrey Brozozog Lee,
  • Ellen R. Goldman,
  • Richard Dietrich,
  • Erwin Märtlbauer and
  • George P. Anderson

21 November 2016

Marine toxins, such as saxitoxin and domoic acid are associated with algae blooms and can bioaccumulate in shell fish which present both health and economic concerns. The ability to detect the presence of toxin is paramount for the administration of...

  • Review
  • Open Access
53 Citations
13,467 Views
15 Pages

19 November 2016

Clostridium perfringens is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic i...

  • Article
  • Open Access
31 Citations
7,142 Views
17 Pages

19 November 2016

Alternaria (A.) is a genus of widespread fungi capable of producing numerous, possibly health-endangering Alternaria toxins (ATs), which are usually not the focus of attention. The formation of ATs depends on the species and complex interactions of v...

  • Article
  • Open Access
34 Citations
6,514 Views
20 Pages

Effect of Fusarium-Derived Metabolites on the Barrier Integrity of Differentiated Intestinal Porcine Epithelial Cells (IPEC-J2)

  • Alexandra Springler,
  • Galina-Jacqueline Vrubel,
  • Elisabeth Mayer,
  • Gerd Schatzmayr and
  • Barbara Novak

19 November 2016

The human, animal and plant pathogen Fusarium, which contaminates agricultural commodities worldwide, produces numerous secondary metabolites. An example is the thoroughly-investigated deoxynivalenol (DON), which severely impairs gastrointestinal bar...

  • Article
  • Open Access
86 Citations
9,776 Views
18 Pages

Occurrence of Fusarium Mycotoxins in Cereal Crops and Processed Products (Ogi) from Nigeria

  • Cynthia Adaku Chilaka,
  • Marthe De Boevre,
  • Olusegun Oladimeji Atanda and
  • Sarah De Saeger

18 November 2016

In Nigeria, maize, sorghum, and millet are very important cash crops. They are consumed on a daily basis in different processed forms in diverse cultural backgrounds. These crops are prone to fungi infestation, and subsequently may be contaminated wi...

  • Article
  • Open Access
36 Citations
7,885 Views
12 Pages

18 November 2016

This study was conducted to investigate the natural co-occurrence of multiple toxic fungal and bacterial metabolites in sugarcane grass and juice intended for human consumption in Upper Egypt. Quantification of the target analytes has been done using...

  • Article
  • Open Access
51 Citations
7,689 Views
16 Pages

Deoxynivalenol and Its Modified Forms: Are There Major Differences?

  • Arash Alizadeh,
  • Saskia Braber,
  • Peyman Akbari,
  • Aletta Kraneveld,
  • Johan Garssen and
  • Johanna Fink-Gremmels

16 November 2016

Considering the diverse toxic effects of the Fusarium toxin deoxynivalenol (DON), its common occurrence in wheat-based products, and its stability during processing, DON constitutes an increasing health concern for humans and animals. In addition to...

  • Article
  • Open Access
87 Citations
8,682 Views
15 Pages

Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted with Fusarium graminearum

  • Ye Tian,
  • Yanglan Tan,
  • Na Liu,
  • Zheng Yan,
  • Yucai Liao,
  • Jie Chen,
  • Sarah De Saeger,
  • Hua Yang,
  • Qiaoyan Zhang and
  • Aibo Wu

15 November 2016

Deoxynivalenol (DON) is a mycotoxin mainly produced by the Fusarium graminearum complex, which are important phytopathogens that can infect crops and lead to a serious disease called Fusarium head blight (FHB). As the most common B type trichothecene...

  • Article
  • Open Access
23 Citations
6,782 Views
13 Pages

Comparison of In-Solution Biorecognition Properties of Aptamers against Ochratoxin A

  • Maureen McKeague,
  • Ranganathan Velu,
  • Annalisa De Girolamo,
  • Stefania Valenzano,
  • Michelangelo Pascale,
  • McKenzie Smith and
  • Maria C. DeRosa

15 November 2016

Ochratoxin A (OTA) is a mycotoxin produced as a secondary metabolite by several species of Aspergillus and Penicillium and frequently found as a natural contaminant in a wide range of food commodities. Novel and robust biorecognition agents for detec...

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Toxins - ISSN 2072-6651