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Toxins, Volume 16, Issue 3

March 2024 - 52 articles

Cover Story: Heterogeneity in the composition and potency of venom from disparate populations of Eastern Russell’s vipers (Daboia siamensis) has repercussions for the efficacy of antivenoms, which is particularly true when antivenoms are restricted by their geographical utility. In such cases, alternative therapies following envenoming, which are not limited by species specificity, may be employed to complement antivenoms. In this study, the neuromuscular activity of D. siamensis venom from Thailand and Java (Indonesia) and the ability of Thai antivenoms and/or Varespladib to prevent or reverse these effects were explored. With an improvement in recovery from the pre-synaptic effects, the results suggest that small molecule inhibitors may help to relieve antivenom restrictions or improve overall efficacy. View this paper
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Articles (52)

  • Article
  • Open Access
11 Citations
4,991 Views
18 Pages

New Analytical Approach to Quinolizidine Alkaloids and Their Assumed Biosynthesis Pathways in Lupin Seeds

  • Dvory Namdar,
  • Patrick P. J. Mulder,
  • Eyal Ben-Simchon,
  • Yael Hacham,
  • Loai Basheer,
  • Ofer Cohen,
  • Marcelo Sternberg and
  • Oren Shelef

21 March 2024

Alkaloids play an essential role in protecting plants against herbivores. Humans can also benefit from the pharmacological effects of these compounds. Plants produce an immense variety of structurally different alkaloids, including quinolizidine alka...

  • Review
  • Open Access
4 Citations
11,836 Views
20 Pages

Botulinum Toxin Injections to Manage Sequelae of Peripheral Facial Palsy

  • Fabienne Carré,
  • Jérémy Amar,
  • Frédéric Tankéré and
  • Claire Foirest

20 March 2024

Long-standing facial palsy sequelae cause functional, aesthetic, and psychological problems in patients. Botulinum toxin is an effective way to manage them, but no standardized recommendations exist. Through this non-systematic review, we aimed to gu...

  • Article
  • Open Access
2 Citations
3,747 Views
17 Pages

Exploration of Cytochrome P450-Related Interactions between Aflatoxin B1 and Tiamulin in Broiler Chickens

  • Pan Sun,
  • Orphélie Lootens,
  • Tadele Kabeta,
  • Diethard Reckelbus,
  • Natalia Furman,
  • Xingyuan Cao,
  • Suxia Zhang,
  • Gunther Antonissen,
  • Siska Croubels and
  • Marthe De Boevre
  • + 1 author

20 March 2024

Poultry may face simultaneous exposure to aflatoxin B1 (AFB1) and tiamulin (TIA), given mycotoxin contamination and antibiotic use. As both mycotoxins and antibiotics can affect cytochrome P450 enzymes (CYP450), our study aimed to explore their inter...

  • Article
  • Open Access
2 Citations
3,408 Views
20 Pages

Comprehensive Analysis of Bufadienolide and Protein Profiles of Gland Secretions from Medicinal Bufo Species

  • Yunge Fang,
  • Liangmian Chen,
  • Pengfei Wang,
  • Yating Liu,
  • Yuxiu Wang,
  • Zhimin Wang,
  • Yue Ma and
  • Huimin Gao

20 March 2024

Toad Venom (TV) is the dried product of toxic secretions from Bufo bufo gargarizans Cantor (BgC) or B. melanostictus Schneider (BmS). Given the increasing medical demand and the severe depletion of wild toads, a number of counterfeit TVs appeare...

  • Article
  • Open Access
22 Citations
4,704 Views
21 Pages

Dietary Exposure and Risk Assessment of Multi-Mycotoxins (AFB1, AFM1, OTA, OTB, DON, T-2 and HT-2) in the Lebanese Food Basket Consumed by Adults: Findings from the Updated Lebanese National Consumption Survey through a Total Diet Study Approach

  • Maha Hoteit,
  • Zahraa Abbass,
  • Rouaa Daou,
  • Nikolaos Tzenios,
  • Lamis Chmeis,
  • Joyce Haddad,
  • Mohamad Chahine,
  • Elham Al Manasfi,
  • Abdulrahman Chahine and
  • Omasyarifa Binti Jamal Poh
  • + 1 author

19 March 2024

Mycotoxins have been linked to adverse health impacts, including liver cancer and kidney diseases. The objectives of the current study were to evaluate the dietary exposure of Lebanese adults to multi-mycotoxins (aflatoxin B1 (AFB1), aflatoxin M1 (AF...

  • Article
  • Open Access
3 Citations
5,149 Views
20 Pages

Paradoxical Exception to Island Tameness: Increased Defensiveness in an Insular Population of Rattlesnakes

  • William K. Hayes,
  • Carl E. Person,
  • Gerad A. Fox,
  • Julie L. King,
  • Erick Briggs and
  • Eric C. K. Gren

18 March 2024

Island tameness results largely from a lack of natural predators. Because some insular rattlesnake populations lack functional rattles, presumably the consequence of relaxed selection from reduced predation, we hypothesized that the Santa Catalina Is...

  • Article
  • Open Access
2 Citations
2,574 Views
13 Pages

18 March 2024

The ESKAPE pathogen-associated antimicrobial resistance is a global public health issue, and novel therapeutic strategies are urgently needed. The short cationic antimicrobial peptide (AMP) family represents an important subfamily of scorpion-derived...

  • Article
  • Open Access
3 Citations
3,324 Views
13 Pages

Unveiling the Diversity and Modifications of Short Peptides in Buthus martensii Scorpion Venom through Liquid Chromatography-High Resolution Mass Spectrometry

  • Ling Zeng,
  • Cangman Zhang,
  • Mingrong Yang,
  • Jianfeng Sun,
  • Jingguang Lu,
  • Huixia Zhang,
  • Jianfeng Qin,
  • Wei Zhang and
  • Zhihong Jiang

16 March 2024

More recently, short peptides in scorpion venom have received much attention because of their potential for drug discovery. Although various biological effects of these short peptides have been found, their studies have been hindered by the lack of s...

  • Article
  • Open Access
6 Citations
2,989 Views
14 Pages

The Effects of T-2 Toxin, Deoxynivalenol, and Fumonisin B1 on Oxidative Stress-Related Genes in the Kidneys of Laying Hens

  • Benjamin Kövesi,
  • Szabina Kulcsár,
  • Zsolt Ancsin,
  • Márta Erdélyi,
  • Erika Zándoki,
  • Patrik Gömbös,
  • Krisztián Balogh and
  • Miklós Mézes

16 March 2024

In the context of nephrotoxic risks associated with environmental contaminants, this study focused on the impact of mycotoxin exposure on the renal health of laying hens, with particular attention to oxidative stress pathways. Sixty laying hens were...

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Toxins - ISSN 2072-6651