Proteomic Analysis and Functional Characterization of Venom
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 12458
Special Issue Editors
Interests: venom proteomic analysis; analytical techniques; mass spectrometry; diagnostic/prognostic biomarkers; clinical proteomics
2. Departamento de Medicina, Universidade Federal de Rondônia, Porto Velho 76801-059, RO, Brazil
Interests: snake venom toxins; pathophysiology; molecular mechanisms of action; envenomation; inflammatory responses; innate immunity; signaling pathways; inflammatory mediators
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Special Issue Information
Dear Colleagues,
Studies conducted over the past 50 years have revealed the diversity of animal venoms’ chemical composition, and further research is increasingly exploring the synergic and/or individual effects of toxins. Improvements in modern instrumentation have supported large-scale measurement of animal venom proteomes, such as:
- Purification of proteins and peptides by liquid chromatography (LC);
- Analysis of selective proteins by enzyme-linked immunosorbent assay (ELISA) and Western blotting;
- Separation of complex protein samples by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), two-dimensional gel electrophoresis (2-DE) and two-dimensional differential gel electrophoresis (2D-DIGE) techniques;
- Mass spectrometry (MS) for analyzing the complex protein mixtures with higher sensitivity;
- Free and stable isotopes labeling (ICAT, SILAC and iTRAQ) techniques for quantitative proteomic;
- X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy providing three-dimensional (3D) structure of protein, furthering the understanding of its biological function;
- Bioinformatics tools for 3D structure prediction, protein domain and motif analysis, rapid analysis of protein–protein interaction, evolutionary relationship and data analysis of MS.
This Special Issue will cover recent progress in proteomics techniques for the proteome and functional characterization of animal venoms and/or individual toxins to promote an improved understanding of the mechanisms of envenomation and/or to reveal bioactive molecules for the development of novel drugs.
Dr. Lucilene Delazari dos Santos
Dr. Juliana Pavan Zuliani
Prof. Dr. Andreimar M. Soares
Guest Editors
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Keywords
- venom proteomic analysis
- venomous animals
- bioactive molecules
- functional protein characterization, protein quantification
- protein isolation
- peptide sequencing
- mass spectrometry
- bioinformatic proteomic
- proteome database
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