Toxinology of Arthropod Venom Peptides: Chemical and Biomedical Investigation

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".

Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 1407

Special Issue Editors

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Guest Editor
Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan
Interests: chemistry (isolation, structure and synthesis) of natural products; solitary wasp and ant venom peptides; sea anemone toxins; spider toxins
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Guest Editor
Laboratory of Biochemistry and Biotechnology, Institute for Marine Sciences, Federal University of Ceara, Fortaleza 60165-081, CE, Brazil
Interests: transcriptome of arthropods, cnidarians and other venomous animals; peptide engineering; anti-proliferative peptides; membranolytic peptides; regulatory peptides; molecular biology; pharmaceutical biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Arthropods comprise a large and diverse class of marine and terrestrial organisms inhabiting several niches on the planet. Some degree of the evolutionary success of arthropods is related to the production and inoculation of venom, as is the cases of arachnids (spiders and scorpions), hymenopterans (ants, bees, and wasps), and myriapods (centipedes). Peptides and organics are the primary molecular weapons that make up the composition of arthropod venoms. Arthropod venoms are naturally utilized for prey capture and self-defense but sometimes accidentally cause the envenomation of humans, leading to severe injuries. The remarkable biological effects have prompted much interest in arthropod venom components, and consequently, an increased number of studies have been carried out into the chemical composition and biological activities of arthropod venom. Venom component analysis has advanced to an outstanding level of accuracy and sensitivity, revealing the complexity and richness of arthropod venom and leading to the discovery of unique classes of proteins, peptides, and small molecules. Chemical and pharmacological investigation into arthropod venom has been one of the significant topics in the field of toxinology. This Special Issue of Toxins is a sequel to the similar Special Issues, entitled “Arthropod Venom Components and their Potential Usage” and “Toxinologic and Pharmacological Investigation of Venomous Arthropods”, which were published in 2019 and 2021, respectively. This subsequent Special Issue plans to focus on peptide components in arthropod venoms, collecting state-of-the-art progress results.

Prof. Dr. Katsuhiro Konno
Prof. Dr. Gandhi Rádis-Baptista
Guest Editors

Manuscript Submission Information

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  • venom components
  • peptide toxins
  • peptidomics
  • transcriptome
  • venomics
  • neurotixc peptides
  • peptide ligand
  • peptide engineering
  • venom-derived peptide leads

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Published Papers (1 paper)

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13 pages, 2683 KiB  
Unveiling the Diversity and Modifications of Short Peptides in Buthus martensii Scorpion Venom through Liquid Chromatography-High Resolution Mass Spectrometry
by Ling Zeng, Cangman Zhang, Mingrong Yang, Jianfeng Sun, Jingguang Lu, Huixia Zhang, Jianfeng Qin, Wei Zhang and Zhihong Jiang
Toxins 2024, 16(3), 155; - 16 Mar 2024
Viewed by 899
More recently, short peptides in scorpion venom have received much attention because of their potential for drug discovery. Although various biological effects of these short peptides have been found, their studies have been hindered by the lack of structural information especially in modifications. [...] Read more.
More recently, short peptides in scorpion venom have received much attention because of their potential for drug discovery. Although various biological effects of these short peptides have been found, their studies have been hindered by the lack of structural information especially in modifications. In this study, small peptides from scorpion venom were investigated using high-performance liquid chromatography high-resolution mass spectrometry followed by de novo sequencing. A total of 156 sequences consisting of 2~12 amino acids were temporarily identified from Buthus martensii scorpion venom. The identified peptides exhibited various post-translational modifications including N-terminal and C-terminal modifications, in which the N-benzoyl modification was first found in scorpion venom. Moreover, a short peptide Bz-ARF-NH2 demonstrated both N-terminal and C-terminal modifications simultaneously, which is extremely rare in natural peptides. In conclusion, this study provides a comprehensive insight into the diversity, modifications, and potential bioactivities of short peptides in scorpion venom. Full article
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