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Toxins, Volume 16, Issue 12

December 2024 - 51 articles

Cover Story: Epsilon toxin (ETX) from Clostridium perfringens is a pore-forming toxin (PFT) capable of crossing the blood–brain barrier and binding to myelin structures. In vitro assays demonstrate that ETX impairs oligodendrocytes, leading to demyelination. The myelin and lymphocyte protein (MAL) is widely recognized as the receptor for ETX, as its presence is essential for ETX-mediated pore formation in host-cell plasma membranes. Certain cells produce extracellular vesicles (EVs) to mitigate pore formation by some PFTs. In this study, we observed that ETX induces EV formation in HeLa cells overexpressing the MAL-GFP protein. Notably, the MAL protein and ETX oligomers are present in these EVs, providing valuable insights into the mode of action of ETX and its interaction with its receptor. View this paper
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Articles (51)

  • Communication
  • Open Access
2 Citations
2,237 Views
12 Pages

Machine Learning for Predicting Zearalenone Contamination Levels in Pet Food

  • Zhenlong Wang,
  • Wei An,
  • Jiaxue Wang,
  • Hui Tao,
  • Xiumin Wang,
  • Bing Han and
  • Jinquan Wang

23 December 2024

Zearalenone (ZEN) has been detected in both pet food ingredients and final products, causing acute toxicity and chronic health problems in pets. Therefore, the early detection of mycotoxin contamination in pet food is crucial for ensuring the safety...

  • Article
  • Open Access
1,800 Views
7 Pages

Food Confusion Between Edible and Poisonous Plants: A 22-Year Retrospective of the Southeastern France Poison Control Center

  • Romain Torrents,
  • Julien Reynoard,
  • Mathieu Glaizal,
  • Corinne Schmitt,
  • Katharina Von Fabeck,
  • Audrey Boulamery,
  • Luc De Haro and
  • Nicolas Simon

21 December 2024

Objective: In some regions of the globe, accidental food confusion regarding plants can cause severe poisoning events and deaths. The aim of this study was to report on those confusions from the Marseille Poison Control Centre’s (PCC) experienc...

  • Review
  • Open Access
4 Citations
3,348 Views
19 Pages

Lesser-Known Cyanotoxins: A Comprehensive Review of Their Health and Environmental Impacts

  • Molham Al Haffar,
  • Ziad Fajloun,
  • Sami Azar,
  • Jean-Marc Sabatier and
  • Ziad Abi Khattar

19 December 2024

Cyanobacteria, also known as blue-green algae, are a diverse phylum of photosynthetic, Gram-negative bacteria and one of the largest microbial taxa. These organisms produce cyanotoxins, which are secondary metabolites that can have significant impact...

  • Article
  • Open Access
2,615 Views
14 Pages

The Effect of Purified Opharin Isolated from the Venom of King Cobra (Ophiophagus hannah) in Modulating Macrophage Inflammatory Responses and Vascular Integrity

  • Tuchakorn Lertwanakarn,
  • Armando Reyes,
  • Emelyn Salazar,
  • Martha Barrientos,
  • Elda E. Sanchez and
  • Montamas Suntravat

19 December 2024

King cobra (Ophiophagus hannah) venom comprises a diverse array of proteins and peptides. However, the roles and properties of these individual components are still not fully understood. Among these, Cysteine-rich secretory proteins (CRiSPs) are reco...

  • Article
  • Open Access
1 Citations
2,052 Views
14 Pages

18 December 2024

Microcystin-leucine arginine (MC-LR) poses a serious threat to aquatic animals during cyanobacterial blooms. Recently, biochar (BC), derived from rice straw, has emerged as a potent adsorbent for eliminating hazardous contaminants from water. To asse...

  • Communication
  • Open Access
1 Citations
1,493 Views
12 Pages

Brefeldin A—A Major Pathogenic Factor of Peanut Pod Rot from Fusarium neocosmosporiellum

  • Huiling Wang,
  • Xiaohan Wang,
  • Huiling Han,
  • Quanlin Yu,
  • Xinmiao Tan,
  • Junlong Liu,
  • Yiting Zhao and
  • Weiming Sun

18 December 2024

Fusarium neocosmosporiellum is the main pathogen of peanut pod rot in China. To investigate the type of F. neocosmosporiellum toxin and its pathogenic mechanism, a macrolide, brefeldin A, was isolated. The structure of the compound was identified by...

  • Article
  • Open Access
3 Citations
1,953 Views
10 Pages

Ochratoxin A and AFM1 in Cheese and Cheese Substitutes: LC-MS/MS Method Validation, Natural Occurrence, and Risk Assessment

  • María Agustina Pavicich,
  • Stefano Compagnoni,
  • Celine Meerpoel,
  • Katleen Raes and
  • Sarah De Saeger

18 December 2024

Cheese is vulnerable to contamination with mycotoxins, particularly ochratoxin A (OTA) and aflatoxin M1 (AFM1). This study aims to develop and validate an analytical method for the detection and quantification of OTA and AFM1 in cheese and to assess...

  • Systematic Review
  • Open Access
1 Citations
4,059 Views
14 Pages

16 December 2024

Oromandibular dystonia (OMD) is a focal dystonia characterized by contractions of the masticatory, lingual, and other muscles of the stomatognathic system. We conducted a systematic review and meta-analysis to elucidate the impact and safety of botul...

  • Article
  • Open Access
1 Citations
1,814 Views
10 Pages

The Choice of Anti-Inflammatory Influences the Elimination of Protein-Bound Uremic Toxins

  • Víctor Joaquín Escudero-Saiz,
  • Elena Cuadrado-Payán,
  • María Rodriguez-Garcia,
  • Gregori Casals,
  • Lida María Rodas,
  • Néstor Fontseré,
  • María del Carmen Salgado,
  • Carla Bastida,
  • Nayra Rico and
  • José Jesús Broseta
  • + 1 author

16 December 2024

Pain is a frequent and disturbing symptom among hemodialysis patients. Protein-bound uremic toxins (PBUTs) are related to cardiovascular and overall mortality, and they are difficult to remove with current hemodialysis treatments. The PBUT displacers...

  • Article
  • Open Access
3 Citations
4,217 Views
18 Pages

16 December 2024

The therapeutic benefit of the oral adsorbent drug AST-120 in chronic kidney disease (CKD) is related to an indoxyl sulfate (IS)-lowering action. Diabetes and dyslipidemia might worsen kidney damage in CKD. However, it is not known whether AST-120 in...

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Toxins - ISSN 2072-6651