Botulinum Toxin and Migraine: Goals and Perspectives
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 24268
Special Issue Editor
Interests: clinical neurology; adult neurology; headache; botulinum toxins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Migraine is a type of disabling primary headache and is widespread in the general population. Migraine-related disability increases proportionally with headache frequency and reaches its highest levels in chronic migraine, which is often comorbid with psycho and somatic pathologies as well as symptomatic drug overuse.
On 15 October 2010, the U.S. Food and Drug Administration approved onabotulinumtoxinA to prevent headaches in adult patients with chronic migraine. After more than a decade, it is time to take stock of this successful therapeutic option. Many of its aspects deserve in-depth study. For example, what is its precise peripheral antimigraine mechanism of action and how does it exert its possible effects on the central nervous system? Additionally, what is the best paradigm of injection? Can long-term treatment modify the natural history of migraine, and is this therapy useful for episodic migraine or other forms of headaches? Other no less interesting aspects to consider are the possibility of a shorter administration interval to counter the phenomenon of the dose wearing off or the association of the botulinum toxin with antiCGRP antibody therapy in resistant forms. The possibility of extending the indications to migraine patients in adolescence and or of developmental age or for particular conditions such as migraine during pregnancy represent further research topics. Both review and research articles on animal models, clinical studies, case reports, or off-label indications are welcome contributions to this Special Issue, “Botulinum Toxin and Migraine: Goals and Perspectives”.
Dr. Maria Pia Prudenzano
Guest Editor
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Keywords
- onabotulinumtoxinA
- chronic migraine
- injection paradigm
- mechanism of action
- animal models
- clinical study
- case report
- off-label use
- new indications
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